THIOTEPA FOR INJECTION USP
Thiotepa for Injection USP is an ethylenimine-type compound. It is supplied as a non-pyrogenic, sterile Iyophilized powder for intravenous, intracavitary or intravesical administration, containing 15 mg of thiotepa. Thiotepa is a synthetic product with antitumor activity.
Thiotepa (thiotepa INTRACAVITARY) is indicated for the following:
Thiotepa has been tried with varying results in the palliation of a wide variety of neoplastic diseases. However, the most consistent results have been seen in the following tumors:
- Adenocarcinoma of the breast.
- Adenocarcinoma of the ovary.
- For controlling intracavitary effusions secondary to diffuse or localized neoplastic diseases of various serosal cavities.
- For the treatment of superficial papillary carcinoma of the urinary bladder.
While now largely superseded by other treatments, thiotepa has been effective against other lymphomas, such as lymphosarcoma and Hodgkin's disease.
Published Studies Related to Thiotepa (Thiotepa Intracavitary)
[Randomized clinical case-control trial for the comparison of docetaxel plus thiotepa versus docetaxel plus capecitabine in patients with metastatic breast cancer]. [2011.02.18]
OBJECTIVE: To evaluate the efficacy and safety of docetaxel plus thiotepa(TXT/TSPA) and docetaxel plus capecitabine(TXT/CAPE) in patients with metastatic breast cancer... CONCLUSION: Combination of docetaxel and thiotepa in the treatment of metastatic breast cancer has some curative effect and adverse reactions can be tolerated. It can be used as an economical and effective rescue plan.
[Randomized clinical case-control trial for the comparison of docetaxel plus
thiotepa versus docetaxel plus capecitabine in patients with metastatic breast
cancer]. [Article in Chinese] 
metastatic breast cancer... CONCLUSION: Combination of docetaxel and thiotepa in the treatment of metastatic
Toxicity of high-dose chemotherapy with etoposide, thiotepa and CY in treating poor-prognosis Ewing's sarcoma family tumors: the experience of the Bambino Gesu Children's Hospital. [2010.08]
We report the toxicity of high-dose chemotherapy (HDC) based on etoposide, thiotepa and CY (ETC) in children with poor-prognosis Ewing's sarcoma family tumors (ESFTs). A total of 26 patients with high-risk ESFT (metastasis or axis localization or tumor volume >200 ml or necrosis <95%) were reviewed...
The chemotherapy agent, thioTEPA, yields long-term impairment of hippocampal cell proliferation and memory deficits but not depression-related behaviors in mice. [2010.05.01]
ThioTEPA is a chemotherapeutic agent used in the treatment of cancers, and more recently has been proposed as a component of high-dose therapy for young patients with recurrent malignant brain tumors. We previously demonstrated a significant dose-dependent reduction of cell proliferation in the dentate gyrus of the hippocampus in mice immediately following a 3-day regiment of thioTEPA...
Remission re-induction chemotherapy with clofarabine, topotecan, thiotepa, and vinorelbine for patients with relapsed or refractory leukemia. [2010.05]
CONCLUSION: TVTC has significant anti-leukemic activity in both acute lymphoblastic and myeloblastic leukemia. The MTD of clofarabine is 40 mg/m(2)/day in this combination. This is the recommended dose for the phase II study in patients with refractory or relapsed leukemia, a population which has limited therapeutic options.
Clinical Trials Related to Thiotepa (Thiotepa Intracavitary)
Temozolomide,Thiotepa and Carboplatin With Autologous Stem Cell Rescue Followed by 13-cis-retinoic Acid in Patients With Recurrent/Refractory Malignant Brain Tumors [Recruiting]
The purpose of this study is to:
Find out how safe and effective (by monitoring the good and/or bad effects) treatment with
high dose temozolomide, thiotepa and carboplatin with stem cell rescue followed by
13-cis-retinoic acid has on children and adolescents with recurrent/refractory brain tumors
Find out how the body uses 13-cis-retinoic acid by studying the your blood levels and
proteins in the blood that break down the 13-cis-retinoic acid
Determine how well 13-cis-retinoic acid penetrates into the spinal fluid.
Busulfan, Melphalan, and Thiotepa in Treating Patients Who Are Undergoing an Autologous Stem Cell Transplant for Hodgkin's or Non-Hodgkin's Lymphoma [Recruiting]
RATIONALE: Chemotherapy, such as busulfan, melphalan, and thiotepa, may destroy cancerous
blood-forming cells (stem cells) in the blood and bone marrow. Giving the patient their
healthy stem cells will help their bone marrow make new stem cells that become red blood
cells, white blood cells, and platelets.
PURPOSE: This phase II trial is studying how well busulfan, melphalan, and thiotepa work in
treating patients who are undergoing an autologous stem cell transplant for Hodgkin's or
Thiotepa Followed by Peripheral Stem Cell or Bone Marrow Transplant in Treating Patients With Malignant Glioma [Completed]
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from
dividing so they stop growing or die. Giving chemotherapy with peripheral stem cell or bone
marrow transplant may allow the doctor to give higher doses of chemotherapy drugs and kill
more tumor cells.
PURPOSE: This phase II trial is studying how well thiotepa followed by peripheral stem cell
or bone marrow transplant works in treating patients with malignant glioma.
Clofarabine, Melphalan, and Thiotepa Followed By a Donor Stem Cell Transplant in Treating Patients With High-Risk and/or Advanced Hematologic Cancer or Other Disease [Recruiting]
RATIONALE: Giving chemotherapy, such as clofarabine, melphalan, and thiotepa, before a donor
stem cell transplant helps stop the growth of cancer or abnormal cells. It also helps stop
the patient's immune system from rejecting the donor's stem cells. When the healthy stem
cells from a donor are infused into the patient they may help the patient's bone marrow make
stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted
cells from a donor can also make an immune response against the body's normal cells. Giving
tacrolimus and mycophenolate mofetil before the transplant may stop this from happening.
PURPOSE: This phase I/II trial is studying the side effects and best dose of clofarabine
when given together with melphalan and thiotepa, followed by a donor stem cell transplant
and to see how well it works in treating patients with high-risk and/or advanced hematologic
cancer or other disease.
Cord Blood Fucosylation [Recruiting]
The goal of this clinical research study is to learn if it is safe and feasible to
transplant changed cord blood for patients with leukemia or lymphoma. Researchers also want
to learn if this can help to control the disease.
The cord blood will be changed to make use of sugar that is found in small amounts in blood
cells. It plays a role in signaling where in the body the transplanted cells should go to.
Adding more sugars to the cord blood cells in the laboratory is designed to help the cord
blood cells find their way faster to the bone marrow. This may help your blood counts to
recover faster. This process is called fucosylation.
Anti-thymocyte globulin (ATG) is a protein that removes immune cells that cause damage to
Clofarabine is designed to interfere with the growth and development of cancer cells.
Fludarabine is designed to interfere with the DNA (genetic material) of cancer cells, which
may cause the cancer cells to die. This chemotherapy is also designed to block your body's
ability to reject the donor's bone marrow cells.
Melphalan and busulfan are designed to bind to the DNA of cells, which may cause cancer
cells to die.
Mycophenolate mofetil (MMF) and tacrolimus are designed to block the donor cells from
growing and spreading in a way that could cause graft versus host disease (GVHD - - a
condition in which transplanted tissue attacks the recipient's body). This may help to
Rituximab is designed to attach to cancer cells, which may cause them to die.
Reports of Suspected Thiotepa (Thiotepa Intracavitary) Side Effects
Respiratory Failure (9),
Acute Respiratory Distress Syndrome (7),
Immunosuppression (4), more >>