NEWS HIGHLIGHTSMedia Articles Related to Theolair (Theophylline)
Asthma Combo Seems Less Influenced by Genes (HealthDay)
Source: Y! Health Asthma News [2009.11.19]
HealthDay - THURSDAY, Nov. 19 (HealthDay News) -- People's genetic makeup has
been shown to affect how they respond to asthma medications, but a new
study finds that many people respond well to a particular combination
treatment regardless of their genes.
Annals Of Allergy, Asthma And Immunology To Be Published By Elsevier
Source: Allergy News From Medical News Today [2009.11.18]
Elsevier is pleased to announce that beginning with Volume 104 (2010) it will assume publication of the Annals of Allergy, Asthma & Immunology, the official journal of the American College of Allergy, Asthma & Immunology (ACAAI). The i>Annals of Allergy, Asthma & Immunology, published since 1942, will continue under the leadership of Editor Gailen D. Marshall, MD, PhD and a distinguished editorial board.
Folic Acid Late in Pregnancy Tied to Asthma in Kids
Source: MedicineNet Asthma Specialty [2009.11.16]
Title: Folic Acid Late in Pregnancy Tied to Asthma in Kids
Category: Health News
Created: 11/13/2009 2:10:00 PM
Last Editorial Review: 11/16/2009
New Research Shows Over-use Of Asthma Rescue Inhalers Substantially Reduced Through Pharmacist-initiated Physician Intervention
Source: Respiratory / Asthma News From Medical News Today [2009.11.13]
Research presented at the American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting shows that an intervention to reduce over-dispensing and waste of asthma medications can succeed without compromising patient safety and can result in substantial cost savings. Medco Health Solutions, Inc.
'The Pill' May Reduce Asthma Symptoms (HealthDay)
Source: Y! Health Asthma News [2009.11.13]
HealthDay - FRIDAY, Nov. 13 (HealthDay News) -- Women with asthma may notice that
their asthma symptoms get worse at certain times of the month. Now, a new
study confirms that fluctuating female hormone levels appear to affect
airway inflammation, but oral contraceptives might help ease those
changes.
Published Studies Related to Theolair (Theophylline)
Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study. [2009.05]
Smoking is common in asthma and is associated with worse asthma control and a reduced therapeutic response to corticosteroids. The present authors hypothesised that treating smokers with asthma with low-dose theophylline added to inhaled corticosteroids would enhance steroid sensitivity and thereby improve lung function and symptoms.
Low-dose theophylline enhances the anti-inflammatory effects of steroids during exacerbations of COPD. [2009.05]
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterised by an abnormal inflammatory response mainly to cigarette smoke that flares up during exacerbations of the disease (ECOPD). Reduced activity of histone deacetylases (HDAC) contributes to enhanced inflammation in stable COPD. It was hypothesised that HDAC activity is further reduced during ECOPD and that theophylline, an HDAC activator, potentiates the anti-inflammatory effect of steroids in these patients. A study was performed to investigate HDAC activity during ECOPD and the effects of theophylline on the anti-inflammatory effects of steroids in a randomised single-blind controlled study... CONCLUSIONS: During ECOPD, low-dose theophylline increases HDAC activity and improves the anti-inflammatory effects of steroids. Trial registration number: NCT00671151.
Treatment of moderate chronic obstructive pulmonary disease (stable) with doxofylline compared with slow release theophylline--a multicentre trial. [2008.12]
An open, randomised trial was conducted at Burdwan Medical College and Midnapore Medical College in West Bengal to investigate therapeutic efficacy and tolerability of doxofylline compared with slow release theophylline in 75 patients (45 males and 30 females) aged between 40 and 70 years who had been suffering from moderate chronic obstructive pulmonary disease...
A randomized controlled trial of theophylline versus CO2 inhalation for treating apnea of prematurity. [2008.10]
OBJECTIVE: To determine whether inhalation of 0.8% CO(2) in preterm infants decreases the duration and rate of apnea as effectively as or better than theophylline with fewer adverse side effects... CONCLUSIONS: Our findings suggest that inhaled low (0.8%) CO(2) concentrations in preterm infants is at least as effective as theophylline in decreasing the duration and number of apneic episodes, has fewer side effects, and causes no changes in CBFV. We speculate that CO(2) may be a better treatment for apnea of prematurity than methylxanthines.
Low-dose theophylline reduces symptoms of acute mountain sickness. [2008.09]
OBJECTIVE: Headache, nausea, and sleeplessness at altitude [acute mountain sickness (AMS)] are major health problems for several million mountain recreationists who ascend to high altitudes each year. We aimed to test the efficacy of low-dose, slow-release theophylline for the prevention of AMS in a placebo-controlled, double-blind, randomized trial... CONCLUSIONS: Low-dose, slow-release theophylline reduces symptoms of AMS in association with alleviation of events of periodic breathing and oxygen desaturations.
Clinical Trials Related to Theolair (Theophylline)
Rosiglitazone Versus Theophylline in Asthmatic Smokers [Completed]
Asthmatic smokers display a blunted response to both inhaled and oral corticosteroid
treatments and are at increased risk for exacerbations and near fatal asthma. The prevalence
of smoking in asthmatics runs between 20-30%. Therefore, new, more efficacious treatments are
required.
Recent work has demonstrated a mechanism which may explain steroid resistance. A commonly
used drug called theophylline can reverse this steroid resistance in laboratory studies.
Another commonly used drug, rosiglitazone can reverse smoking induced lung inflammation in
laboratory studies.
The investigators aim to study the effects of these drugs on smoking asthmatics' lung
function and other parameters including quality of life and asthma control.
Effects of Low-Dose Theophylline During Chronic Obstructive Pulmonary Disease (COPD) Exacerbations [Completed]
Molecular mechanisms of COPD exacerbations and the modulating effect of low dose theophylline
on that inflammation are elucidated in this project. NF-kappa B-dependent pathway and
acetylation status of nuclear histones are to be studied. Design: controlled, prospective and
randomized study with or without theophylline, a potent HDAC activator. Objectives: 1) To
determine NF-kB activation, histone deacetylase (HDAC) and histone acetyl-transferase (HAT)
activity in sputum macrophages and blood monocytes during an episode of exacerbation and 3
months later, once stability is achieved. To correlate these measurements with inflammatory
and oxidative stress markers and with pulmonary function and clinical variables. 2) To
assess the effect of theophylline on previous molecular, functional and clinical data.
Method: 25 patients with COPD will be recruited during an episode of exacerbation requiring
hospitalization. NF-kB activation, HDAC and HAT activity, markers of inflammation and
oxidative stress will be determined with specific assays. These determinations will be
repeated once the patient is stable and compared with smokers and non smoker controls with
normal lung function
Theophylline in Treating Cancer Patients With Shortness of Breath [Active, not recruiting]
RATIONALE: Theophylline may help to relieve shortness of breath in patients who have cancer.
It is not yet known whether theophylline is more effective than no further treatment for
shortness of breath.
PURPOSE: Randomized phase III trial to determine the effectiveness of theophylline in
treating shortness of breath in patients who have cancer.
Acetylcysteine, Theophylline, and a Combination of Both in the Prophylaxis of Contrast-Induced Nephropathy [Completed]
Several studies demonstrated a significant reduction of contrast-induced nephropathy (CIN;
definition: increase in serum creatinine of >=0. 5mg/dl and/or >=25% increase within 48h after
contrast-medium) by acetylcysteine (A) or theophylline (T). However, the results are
contradictory. Therefore, it was the aim of our double-blind study to compare the effects of
A, T, a combination of A and T (A+T), and placebo (P).
Theophylline in Chronic Obstructive Pulmonary Disease [Recruiting]
This will be a prospective randomized double-blinded parallel group clinical trial
evaluating the short-term effects of theophylline therapy on exercise duration and lung
function in patients with chronic obstructive pulmonary disease already receiving both
tiotropium and a long-acting beta-agonist (salmeterol or formoterol).
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