NEWS HIGHLIGHTSMedia Articles Related to Theo-24 (Theophylline)
Antifungal Therapy Could Benefit Nearly 5 Million Asthmatics Worldwide
Source: Health News from Medical News Today [2013.05.11]
An estimated 4,837,000 asthmatics with allergic bronchopulmonary aspergillosis (ABPA) could benefit substantially from antifungal treatment, say researchers from the University of Toronto and Manchester University. Their work, published in the journal Medical Mycology, has also re-estimated the total number of asthmatics worldwide - to reveal a staggering 193 million sufferers. Twenty-four million asthma sufferers live in the United States, 20 million each in India and China, and seven million in the United Kingdom...
Needle-Free Relief For Children From Asthma And Allergies
Source: Allergy News From Medical News Today [2013.05.09]
Allergy shots are commonly used to treat children with severe environmental allergies and asthma, but under-the-tongue drops may offer yet another beneficial - and stick-free - option for pediatric allergy sufferers, according to a Johns Hopkins Children's Center review of existing scientific evidence...
How A Text Message A Day Can Keep The Asthma Attack Away
Source: Respiratory / Asthma News From Medical News Today [2013.05.02]
Simply sending children with asthma a text message each day asking about their symptoms and providing knowledge about their condition can lead to improved health outcomes...
Asthma Care Deteriorates After Age 18
Source: Health Insurance / Medical Insurance News From Medical News Today [2013.04.24]
It is widely accepted that medical insurance helps older adults with chronic health problems to receive better care...
Insurance Loss Hampers Young People With Asthma
Source: MedicineNet Asthma Specialty [2013.04.22]
Title: Insurance Loss Hampers Young People With Asthma
Category: Health News
Created: 4/22/2013 10:35:00 AM
Last Editorial Review: 4/22/2013 12:00:00 AM
Published Studies Related to Theo-24 (Theophylline)
Beneficial effects of theophylline infusions in surgical patients with intra-abdominal hypertension. [2011.08]
BACKGROUND: Intra-abdominal hypertension (IAH) can cause high mortality. Recently, we found that IAH was associated with increased serum levels of adenosine and interleukin 10. Our present "hypothesis-generated study" was based on the above mentioned results... CONCLUSIONS: Adenosine receptor antagonism with T following IAH diagnosis resulted in markedly reduced mortality in patients with moderated IAH (<20 mmHg). Theophylline-associated mortality reduction may be related to improved renal perfusion and improved MAP, presumably caused by adenosine receptor blockade. Because this study was not a randomized controlled study, these compelling observations require further multicentric clinical confirmation.
Study investigating pharmacokinetic interaction between theophylline and roflumilast in healthy adults. [2011.07]
OBJECTIVE: To investigate whether a pharmacokinetic drug-drug interaction exists between theophylline (THEO), a CYP1A2 substrate with a narrow therapeutic index, and the concomitant substrate roflumilast (ROF), a novel selective PDE4 inhibitor partially metabolized by CYP1A2... CONCLUSIONS: Neither ROF nor its main metabolite had any impact on the metabolism of the concomitant CYP1A2 substrate THEO in humans. Though co-administration of THEO resulted in a minor increase (28%) in total ROF exposure, no safety or tolerability concerns and no altered total PDE4 inhibition of both ROF and R-NO, were observed.
Prevention of contrast-induced acute kidney injury by theophylline in elderly patients with chronic kidney disease. [2010.11]
Although the optimal strategy for preventing contrast-induced acute kidney injury (CI-AKI) has not yet been established, the current strategy focuses on adequate periprocedural hydration, the use of a low amount of low or iso-osmolar contrast medium, and the application of adjunctive therapies, including hemofiltration, hemodialysis and drugs...
Prevention of contrast-induced acute kidney injury by theophylline in elderly patients with chronic kidney disease. [2010.09.29]
Although the optimal strategy for preventing contrast-induced acute kidney injury (CI-AKI) has not yet been established, the current strategy focuses on adequate periprocedural hydration, the use of a low amount of low or iso-osmolar contrast medium, and the application of adjunctive therapies, including hemofiltration, hemodialysis and drugs...
Adenosine receptor inhibition with theophylline attenuates the skin blood flow response to local heating in humans. [2010.09]
Mechanisms underlying the robust cutaneous vasodilatation in response to local heating of human skin remain unresolved. Adenosine receptor activation has been shown to induce vasodilatation via nitric oxide, and a substantial portion of the plateau phase to local heating of human skin has been shown to be dependent on nitric oxide...
Clinical Trials Related to Theo-24 (Theophylline)
Neo-Adjuvant Therapy and the Effect on Synchronous Metastatic Growth [Recruiting]
Study Hypothesis
• As well as in animal models as in patients with colorectal cancer resection of the primary
tumor resulted in increase in vascular density, metabolism and secondary tumor growth of the
distant metastases. These data strongly suggest an inhibitory effect of the primary tumor on
the outgrowth of its metastases.
In this study we investigate whether pre-operative treatment with the anti-angiogenic agent
bevacizumab and/or chemotherapy before resection of the primary colorectal tumor shifts the
balance between angiogenic and anti-angiogenic factors in favor of the anti-angiogenic
factors and results in reduced growth of the liver metastases.
Eligibility
- Histological proven colorectal cancer without signs of bowel obstruction or bleeding
- Synchronous liver metastases
- WHO performance status 0-1
Treatment
- Arm A: immediate surgery of the primary colorectal tumor, no neoadjuvant therapy
- Arm B: neoadjuvant treatment with bevacizumab during 7 weeks prior to surgery of the
colorectal primary
- Arm C: neoadjuvant treatment with CAPOX during 7 weeks prior to surgery of the
colorectal primary
- Arm D: neoadjuvant treatment with bevacizumab and CAPOX during 7 weeks prior to surgery
of the colorectal primary
Primary endpoint Difference in response of liver metastases to resection of the primary
tumor between the experimental groups and the control group, as determined by
histopathological scoring of vascular density, apoptotic and mitotic index and by
measurement of the metabolic activity of liver metastases by FDG-PET and SUV measurements.
Secondary endpoints Toxicity of neo-adjuvant treatment Complications of surgery
Evaluation of Metabolic Activity of Liver Metastases by FDG-PET Scanning [Recruiting]
The purpose of this study is to evaluate the effect of primary tumor resection on the
metabolic activity of metastases in patients with a colorectal primary tumor and synchronous
liver metastases by positron emission tomography (PET) with 2-deoxy-2-fluoro[18F]-D-glucose
(FDG-PET) scanning.
Optical Detection of Malignancy During Percutaneous Interventions [Recruiting]
Investigation of application possibilities of optical spectroscopy within the field of
oncology. Optical spectroscopy enables the possibility to specifically differentiate between
different (human) tissues. The hypothesis is that incorporation of this technique into
existing medical devices (e. g. biopsy needle) would enlarge the accuracy and reliability of
these devices. The purpose is to improve and speed up the diagnostics and therapy of the
malignancies.
Optical Detection of Peripheral Nerve Bundles During Surgery [Recruiting]
Investigation of application possibilities of optical spectroscopy within the field of
surgical resection procedures to spare nerve tissue. Optical spectroscopy enables the
possibility to specifically differentiate between different (human) tissues. The hypothesis
is that incorporation of this technique into existing medical devices (e. g. medical blade)
would enlarge the accuracy and reliability of these devices. Sparing of nerve bundles during
surgery can lead to decreased postoperative morbidity rates.
Washing Without Water: Cost-effectiveness of a Rapidly Spreading Nursing Intervention in Bedridden Patients' [Recruiting]
The purpose of this study is to compare the traditional bed bath with 'washing without
water' on
- 1) effects on skin integrity
- 2) patient and nurse satisfaction and 3) costs. In a cluster randomized trial we will
randomize 50 nursing home wards (576 patients) to 'washing without water' or
traditional bed baths. Bathing regimens are continued for six weeks.
Whereas effects on skin damage are not likely to be specific for setting, these results can
be generalized to other patient groups.
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