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Theo-24 (Theophylline, Anhydrous) - Summary

 
 



THEO-24 SUMMARY

Theo-24®
(theophylline anhydrous)
Extended-release capsules 100, 200, 300, & 400 mg

Theophylline is structurally classified as a methylxanthine. It occurs as a white, odorless, crystalline powder with a bitter taste.

Theophylline is indicated for the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis.


See all Theo-24 indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Theo-24 (Theophylline)

Asthma: just believing an odor is harmful 'could trigger airway inflammation'
Source: Respiratory / Asthma News From Medical News Today [2014.07.23]
For asthmatics, 'it's not just what you smell, but also what you think you smell.' Researchers found that just believing an odor is harmful can cause airway inflammation.

Obesity During Pregnancy Linked to Raised Asthma Risk in Kids
Source: MedicineNet Obesity (Weight Loss) Specialty [2014.07.23]
Title: Obesity During Pregnancy Linked to Raised Asthma Risk in Kids
Category: Health News
Created: 7/22/2014 4:36:00 PM
Last Editorial Review: 7/23/2014 12:00:00 AM

Asthma Drug May Help Those With Chronic Hives
Source: MedicineNet Hives Specialty [2014.07.22]
Title: Asthma Drug May Help Those With Chronic Hives
Category: Health News
Created: 7/21/2014 2:36:00 PM
Last Editorial Review: 7/22/2014 12:00:00 AM

Asthma medication linked to growth suppression in children
Source: Respiratory / Asthma News From Medical News Today [2014.07.17]
A review of past studies has found that inhaled corticosteroids used to treat asthma could result in restricting the growth of children who have the condition.

Progress in allergic asthma research after ingestion of fruits
Source: Allergy News From Medical News Today [2014.07.16]
Researchers at the UPM suggest that the interaction between two proteins can be the responsible for the allergic asthma episodes after eating an infected fruit.

more news >>

Published Studies Related to Theo-24 (Theophylline)

Beneficial effects of theophylline infusions in surgical patients with intra-abdominal hypertension. [2011.08]
BACKGROUND: Intra-abdominal hypertension (IAH) can cause high mortality. Recently, we found that IAH was associated with increased serum levels of adenosine and interleukin 10. Our present "hypothesis-generated study" was based on the above mentioned results... CONCLUSIONS: Adenosine receptor antagonism with T following IAH diagnosis resulted in markedly reduced mortality in patients with moderated IAH (<20 mmHg). Theophylline-associated mortality reduction may be related to improved renal perfusion and improved MAP, presumably caused by adenosine receptor blockade. Because this study was not a randomized controlled study, these compelling observations require further multicentric clinical confirmation.

Study investigating pharmacokinetic interaction between theophylline and roflumilast in healthy adults. [2011.07]
OBJECTIVE: To investigate whether a pharmacokinetic drug-drug interaction exists between theophylline (THEO), a CYP1A2 substrate with a narrow therapeutic index, and the concomitant substrate roflumilast (ROF), a novel selective PDE4 inhibitor partially metabolized by CYP1A2... CONCLUSIONS: Neither ROF nor its main metabolite had any impact on the metabolism of the concomitant CYP1A2 substrate THEO in humans. Though co-administration of THEO resulted in a minor increase (28%) in total ROF exposure, no safety or tolerability concerns and no altered total PDE4 inhibition of both ROF and R-NO, were observed.

Prevention of contrast-induced acute kidney injury by theophylline in elderly patients with chronic kidney disease. [2010.11]
Although the optimal strategy for preventing contrast-induced acute kidney injury (CI-AKI) has not yet been established, the current strategy focuses on adequate periprocedural hydration, the use of a low amount of low or iso-osmolar contrast medium, and the application of adjunctive therapies, including hemofiltration, hemodialysis and drugs...

Prevention of contrast-induced acute kidney injury by theophylline in elderly patients with chronic kidney disease. [2010.09.29]
Although the optimal strategy for preventing contrast-induced acute kidney injury (CI-AKI) has not yet been established, the current strategy focuses on adequate periprocedural hydration, the use of a low amount of low or iso-osmolar contrast medium, and the application of adjunctive therapies, including hemofiltration, hemodialysis and drugs...

Adenosine receptor inhibition with theophylline attenuates the skin blood flow response to local heating in humans. [2010.09]
Mechanisms underlying the robust cutaneous vasodilatation in response to local heating of human skin remain unresolved. Adenosine receptor activation has been shown to induce vasodilatation via nitric oxide, and a substantial portion of the plateau phase to local heating of human skin has been shown to be dependent on nitric oxide...

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Clinical Trials Related to Theo-24 (Theophylline)

Neo-Adjuvant Therapy and the Effect on Synchronous Metastatic Growth [Recruiting]
Study Hypothesis

• As well as in animal models as in patients with colorectal cancer resection of the primary tumor resulted in increase in vascular density, metabolism and secondary tumor growth of the distant metastases. These data strongly suggest an inhibitory effect of the primary tumor on the outgrowth of its metastases.

In this study we investigate whether pre-operative treatment with the anti-angiogenic agent bevacizumab and/or chemotherapy before resection of the primary colorectal tumor shifts the balance between angiogenic and anti-angiogenic factors in favor of the anti-angiogenic factors and results in reduced growth of the liver metastases.

Eligibility

- Histological proven colorectal cancer without signs of bowel obstruction or bleeding

- Synchronous liver metastases

- WHO performance status 0-1

Treatment

- Arm A: immediate surgery of the primary colorectal tumor, no neoadjuvant therapy

- Arm B: neoadjuvant treatment with bevacizumab during 7 weeks prior to surgery of the

colorectal primary

- Arm C: neoadjuvant treatment with CAPOX during 7 weeks prior to surgery of the

colorectal primary

- Arm D: neoadjuvant treatment with bevacizumab and CAPOX during 7 weeks prior to surgery

of the colorectal primary

Primary endpoint Difference in response of liver metastases to resection of the primary tumor between the experimental groups and the control group, as determined by histopathological scoring of vascular density, apoptotic and mitotic index and by measurement of the metabolic activity of liver metastases by FDG-PET and SUV measurements.

Secondary endpoints Toxicity of neo-adjuvant treatment Complications of surgery

Evaluation of Metabolic Activity of Liver Metastases by FDG-PET Scanning [Recruiting]
The purpose of this study is to evaluate the effect of primary tumor resection on the metabolic activity of metastases in patients with a colorectal primary tumor and synchronous liver metastases by positron emission tomography (PET) with 2-deoxy-2-fluoro[18F]-D-glucose (FDG-PET) scanning.

Optical Detection of Malignancy During Percutaneous Interventions [Recruiting]
Investigation of application possibilities of optical spectroscopy within the field of oncology. Optical spectroscopy enables the possibility to specifically differentiate between different (human) tissues. The hypothesis is that incorporation of this technique into existing medical devices (e. g. biopsy needle) would enlarge the accuracy and reliability of these devices. The purpose is to improve and speed up the diagnostics and therapy of the malignancies.

Optical Detection of Peripheral Nerve Bundles During Surgery [Recruiting]
Investigation of application possibilities of optical spectroscopy within the field of surgical resection procedures to spare nerve tissue. Optical spectroscopy enables the possibility to specifically differentiate between different (human) tissues. The hypothesis is that incorporation of this technique into existing medical devices (e. g. medical blade) would enlarge the accuracy and reliability of these devices. Sparing of nerve bundles during surgery can lead to decreased postoperative morbidity rates.

Washing Without Water: Cost-effectiveness of a Rapidly Spreading Nursing Intervention in Bedridden Patients' [Recruiting]
The purpose of this study is to compare the traditional bed bath with 'washing without water' on

- 1) effects on skin integrity

- 2) patient and nurse satisfaction and 3) costs. In a cluster randomized trial we will

randomize 50 nursing home wards (576 patients) to 'washing without water' or traditional bed baths. Bathing regimens are continued for six weeks.

Whereas effects on skin damage are not likely to be specific for setting, these results can be generalized to other patient groups.

more trials >>


Page last updated: 2014-07-23

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