NEWS HIGHLIGHTSMedia Articles Related to Theo-24 (Theophylline)
Asthma Combo Seems Less Influenced by Genes (HealthDay)
Source: Y! Health Asthma News [2009.11.19]
HealthDay - THURSDAY, Nov. 19 (HealthDay News) -- People's genetic makeup has
been shown to affect how they respond to asthma medications, but a new
study finds that many people respond well to a particular combination
treatment regardless of their genes.
Annals Of Allergy, Asthma And Immunology To Be Published By Elsevier
Source: Allergy News From Medical News Today [2009.11.18]
Elsevier is pleased to announce that beginning with Volume 104 (2010) it will assume publication of the Annals of Allergy, Asthma & Immunology, the official journal of the American College of Allergy, Asthma & Immunology (ACAAI). The i>Annals of Allergy, Asthma & Immunology, published since 1942, will continue under the leadership of Editor Gailen D. Marshall, MD, PhD and a distinguished editorial board.
Folic Acid Late in Pregnancy Tied to Asthma in Kids
Source: MedicineNet Asthma Specialty [2009.11.16]
Title: Folic Acid Late in Pregnancy Tied to Asthma in Kids
Category: Health News
Created: 11/13/2009 2:10:00 PM
Last Editorial Review: 11/16/2009
New Research Shows Over-use Of Asthma Rescue Inhalers Substantially Reduced Through Pharmacist-initiated Physician Intervention
Source: Respiratory / Asthma News From Medical News Today [2009.11.13]
Research presented at the American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting shows that an intervention to reduce over-dispensing and waste of asthma medications can succeed without compromising patient safety and can result in substantial cost savings. Medco Health Solutions, Inc.
'The Pill' May Reduce Asthma Symptoms (HealthDay)
Source: Y! Health Asthma News [2009.11.13]
HealthDay - FRIDAY, Nov. 13 (HealthDay News) -- Women with asthma may notice that
their asthma symptoms get worse at certain times of the month. Now, a new
study confirms that fluctuating female hormone levels appear to affect
airway inflammation, but oral contraceptives might help ease those
changes.
Published Studies Related to Theo-24 (Theophylline)
Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study. [2009.05]
Smoking is common in asthma and is associated with worse asthma control and a reduced therapeutic response to corticosteroids. The present authors hypothesised that treating smokers with asthma with low-dose theophylline added to inhaled corticosteroids would enhance steroid sensitivity and thereby improve lung function and symptoms.
Low-dose theophylline enhances the anti-inflammatory effects of steroids during exacerbations of COPD. [2009.05]
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterised by an abnormal inflammatory response mainly to cigarette smoke that flares up during exacerbations of the disease (ECOPD). Reduced activity of histone deacetylases (HDAC) contributes to enhanced inflammation in stable COPD. It was hypothesised that HDAC activity is further reduced during ECOPD and that theophylline, an HDAC activator, potentiates the anti-inflammatory effect of steroids in these patients. A study was performed to investigate HDAC activity during ECOPD and the effects of theophylline on the anti-inflammatory effects of steroids in a randomised single-blind controlled study... CONCLUSIONS: During ECOPD, low-dose theophylline increases HDAC activity and improves the anti-inflammatory effects of steroids. Trial registration number: NCT00671151.
Treatment of moderate chronic obstructive pulmonary disease (stable) with doxofylline compared with slow release theophylline--a multicentre trial. [2008.12]
An open, randomised trial was conducted at Burdwan Medical College and Midnapore Medical College in West Bengal to investigate therapeutic efficacy and tolerability of doxofylline compared with slow release theophylline in 75 patients (45 males and 30 females) aged between 40 and 70 years who had been suffering from moderate chronic obstructive pulmonary disease...
A randomized controlled trial of theophylline versus CO2 inhalation for treating apnea of prematurity. [2008.10]
OBJECTIVE: To determine whether inhalation of 0.8% CO(2) in preterm infants decreases the duration and rate of apnea as effectively as or better than theophylline with fewer adverse side effects... CONCLUSIONS: Our findings suggest that inhaled low (0.8%) CO(2) concentrations in preterm infants is at least as effective as theophylline in decreasing the duration and number of apneic episodes, has fewer side effects, and causes no changes in CBFV. We speculate that CO(2) may be a better treatment for apnea of prematurity than methylxanthines.
Low-dose theophylline reduces symptoms of acute mountain sickness. [2008.09]
OBJECTIVE: Headache, nausea, and sleeplessness at altitude [acute mountain sickness (AMS)] are major health problems for several million mountain recreationists who ascend to high altitudes each year. We aimed to test the efficacy of low-dose, slow-release theophylline for the prevention of AMS in a placebo-controlled, double-blind, randomized trial... CONCLUSIONS: Low-dose, slow-release theophylline reduces symptoms of AMS in association with alleviation of events of periodic breathing and oxygen desaturations.
Clinical Trials Related to Theo-24 (Theophylline)
Evaluation of Metabolic Activity of Liver Metastases by FDG-PET Scanning [Recruiting]
The purpose of this study is to evaluate the effect of primary tumor resection on the
metabolic activity of metastases in patients with a colorectal primary tumor and synchronous
liver metastases by positron emission tomography (PET) with 2-deoxy-2-fluoro[18F]-D-glucose
(FDG-PET) scanning.
Neo-Adjuvant Therapy and the Effect on Synchronous Metastatic Growth [Recruiting]
Study Hypothesis
• As well as in animal models as in patients with colorectal cancer resection of the primary
tumor resulted in increase in vascular density, metabolism and secondary tumor growth of the
distant metastases. These data strongly suggest an inhibitory effect of the primary tumor on
the outgrowth of its metastases.
In this study we investigate whether pre-operative treatment with the anti-angiogenic agent
bevacizumab and/or chemotherapy before resection of the primary colorectal tumor shifts the
balance between angiogenic and anti-angiogenic factors in favor of the anti-angiogenic
factors and results in reduced growth of the liver metastases.
Eligibility
- Histological proven colorectal cancer without signs of bowel obstruction or bleeding
- Synchronous liver metastases
- WHO performance status 0-1
Treatment
- Arm A: immediate surgery of the primary colorectal tumor, no neoadjuvant therapy
- Arm B: neoadjuvant treatment with bevacizumab during 7 weeks prior to surgery of the
colorectal primary
- Arm C: neoadjuvant treatment with CAPOX during 7 weeks prior to surgery of the
colorectal primary
- Arm D: neoadjuvant treatment with bevacizumab and CAPOX during 7 weeks prior to surgery
of the colorectal primary
Primary endpoint Difference in response of liver metastases to resection of the primary
tumor between the experimental groups and the control group, as determined by
histopathological scoring of vascular density, apoptotic and mitotic index and by
measurement of the metabolic activity of liver metastases by FDG-PET and SUV measurements.
Secondary endpoints Toxicity of neo-adjuvant treatment Complications of surgery
Legtest Multi Centre Testing of the Lively Legs Program for Promoting Compliance in Leg Ulcer Patients [Recruiting]
Leg ulcers are often chronic or recurring complications of peripheral circulation disorders.
Patients' lifestyles are known to influence leg ulcer occurrence and circulation disorders
in general. Especially exercise and compliance with compression therapy are key elements in
the course of leg ulcer healing and recurrence. Yet many patients demonstrate sedentary
lifestyles and non-compliance and current practice offers no systematic approach in the
promotion of compliance and physical activity in these patients.
The purpose of the study is testing 'Lively Legs' a compliance promotion program for
patients with leg ulcers. The study tests the program on effects regarding:
- compliance with compression therapy and exercise levels
- time to leg ulcer recurrence
- cost effectiveness from a social perspective.
Dose-Reduced Versus Standard Conditioning Prior Allo SCT for MDS/sAML Patients [Recruiting]
The present study is a multicenter, prospective phase III-study comparing dose-reduced
versus standard conditioning followed by allogeneic stem cell transplantation from related
or unrelated donors in patients with MDS or secondary AML.
The hypothesis is that dose-reduced conditioning will reduce the non-relapse mortality from
40% to 20% at one year after allogeneic stem cell transplantation.
Improving Executive Functioning After Traumatic Brain Injury (TBI): A Trial of the "Short Term Executive Plus" Program [Recruiting]
The purpose of this study is to determine the efficacy of an intensive short term cognitive
rehabilitation program aimed towards improving executive functioning in individuals with
traumatic brain injury (TBI).
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