Tham (Tromethamine) - Drug Interactions, Contraindications, Overdosage, etc

DRUG INTERACTIONS

THAM drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.

OVERDOSAGE

Too rapid administration and/or excessive amounts of tromethamine may cause alkalosis, hypoglycemia, overhydration or solute overload. In the event of overdosage, discontinue the infusion, evaluate the patient and institute appropriate countermeasures. See WARNINGS, PRECAUTIONS and ADVERSE REACTIONS.

The LD₅₀ values for the acute intravenous toxicity of THAM are influenced by the rate of infusion of the dose administered.

Intravenous LD₅₀ Mice = 3500 mg/kg

Intravenous LD₅₀ Rats = 2300 mg/kg

CONTRAINDICATIONS

Tham Solution (tromethamine injection) is contraindicated in uremia and anuria. In neonates it is also contraindicated in chronic respiratory acidosis and salicylate intoxication.