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Thallous Tl (Thallous Chloride, TL-201) - Summary



Thallous Chloride Tl 201 Injection is supplied in an isotonic solution as a sterile, non-pyrogenic diagnostic radiopharmaceutical for intravenous administration. Each milliliter contains 37 MBq (1 mCi) Thallous Chloride
Tl 201 at calibration time, made isotonic with 9 milligrams sodium chloride and preserved with 0.9% (v/v) benzyl alcohol. The pH is adjusted to between 4.5 to 7.0 with hydrochloric acid and/or sodium hydroxide. Thallium Tl 201 is cyclotron produced. At the time of calibration it contains no more than 1.0% Thallium Tl 200, no more than 1.0% Thallium Tl 202, no more than 0.25% Lead Pb 203, and no less than 98% Thallium Tl 201 as a percentage of total activity. No carrier has been added. It is recommended to administer Thallous Chloride Tl 201  Injection close to calibration time to minimize the effect of higher levels of radionuclidic contaminants present at pre- and post-calibration dates. The concentration of each radionuclidic contaminant changes with time.

Thallium Chloride Tl 201 Injection is a diagnostic radiopharmaceutical indicated for

  • Myocardial perfusion imaging with planar scintigraphy or single-photon emission computed tomography (SPECT)  for the diagnosis of coronary artery disease by localization of: Non-reversible defects (myocardial infarction) which may have prognostic value regarding survival.
  • Reversible defects (myocardial ischemia) when used in conjunction with exercise or pharmacologic stress.
  • Localization of sites of parathyroid hyperactivity pre- and post- operatively in patients with elevated serum calcium and parathyroid hormone levels.

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    Published Studies Related to Thallous Tl (Thallous Chloride, TL-201)

    Effect of dilantin on myocardial uptake of Tl-201 thallous chloride. A case report. [1992.05]
    Dilantin has been reported to decrease myocardial uptake of Tl-201 thallous chloride by as much as 38.8% in rats. To date, no studies have been done in humans to document the effect of dilantin on the myocardial uptake of thallium or its effect clinically on the interpretation of images obtained while on dilantin.

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    Clinical Trials Related to Thallous Tl (Thallous Chloride, TL-201)

    Comparison of Diagnostic Rest/Stress SPECT Results for Patients With Myocardial Ischemia and Infarction Using Myoview in Both Single and Dual Isotope Acquisition Approaches [Completed]
    The study is designed to determine whether a dual isotope protocol is equivalent to a single isotope in the diagnosis of myocardial ischemia and infarction using MYOVIEW SPECT imaging.

    more trials >>

    Page last updated: 2007-10-18

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