Thalitone (Chlorthalidone) - Drug Interactions, Contraindications, Overdosage

DRUG INTERACTIONS

Drug Interactions Chlorthalidone may add to or potentiate the action of other antihypertensive drugs.

Insulin requirements in diabetic patients may be increased, decreased or unchanged. Higher dosage of oral hypoglycemic agents may be required.

Chlorthalidone and related drugs may increase the responsiveness to tubocurarine.

Chlorthalidone and related drugs may decrease arterial responsiveness to norepinephrine. This diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.

Lithium renal clearance is reduced by chlorthalidone, increasing the risk of lithium toxicity.

OVERDOSAGE

Symptoms of acute overdosage include nausea, weakness, dizziness and disturbances of electrolyte balance. The oral LD₅₀ of the drug in the mouse and the rat is more than 25,000 mg/kg body weight. The minimum lethal dose (MLD) in humans has not been established. There is no specific antidote but gastric lavage is recommended, followed by supportive treatment. Where necessary, this may include intravenous dextrose-saline with potassium, administered with caution.

CONTRAINDICATIONS

Anuria. Known hypersensitivity to chlorthalidone or other sulfonamide-derived drugs.