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Tetracycline (Tetracycline Hydrochloride) - Summary

 

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TETRACYCLINE SUMMARY

TETRACYCLINE HYDROCHLORIDE CAPSULES, USP

Tetracycline is a yellow, odorless, crystalline powder. Tetracycline is stable in air but exposure to strong sunlight causes it to darken. Its potency is affected in solutions of pH below 2 and is rapidly destroyed by alkali hydroxide solutions. Tetracycline is very slightly soluble in water, freely soluble in dilute acid and in alkali hydroxide solutions, sparingly soluble in alcohol, and practically insoluble in chloroform and in ether. Each capsule, for oral administration, contains tetracycline hydrochloride 250 mg or 500 mg.

Tetracycline is indicated in the treatment of infections caused by susceptible strains of the designated organisms in the conditions listed below:

  • Upper respiratory tract infections caused by Streptococcus pyogenes, Streptococcus pneumoniae and Hemophilus influenzae.
    Note: Tetracycline should not be used for streptococcal disease unless the organism has been demonstrated to be susceptible.
  • Lower respiratory tract infections caused by Streptococcus pyogenes, Streptococcus pneumoniae, Mycoplasma pneumoniae (Eaton agent, and Klebsiellasp.)
  • Skin and soft tissue infections caused by Streptococcus pyogenes, Staphylococcus aureaus.
    (Tetracyclines are not the drugs of choice in the treatment of any type of staphylococcal infections.)
  • Infections caused by rickettsia including Rocky Mountain spotted fever, typhus group infections, Q fever, rickettsialpox.
  • Psittacosis of ornithosis caused by Chlamydia psittaci.
  • Infections caused by Chlamydia trachomatis such as uncomplicated urethral, endocervical, or rectal infections, inclusion conjunctivitis, trachoma and lymphogranuloma venereum.
  • Granuloma inquinale caused by Calymmatobacterium granulomatis.
  • Relapsing fever caused by Borrelia sp.
  • Bartonellosis caused by Bartonella bacilli-formis.
  • Chancroid caused by Hemophilus ducreyi.
  • Tularemia caused by Francisella tularensis.
  • Plaque caused by Yersinia pestis.
  • Cholera caused by Vibrio cholerae.
  • Brucellosis caused by Brucella species (tetracycline may be used in conjunction with an aminoglycoside).
  • Infections due to Campylobacter fetus.
  • As adjunctive therapy in intestinal amebiasis caused by Entamoeba histolytica.
  • Urinary tract infections caused by susceptible strains of Escherichia coli, Klebsiella, etc.
  • Other infections caused by susceptible gram-negative organisms such as E. coli, Enterobacter aerogenes, Shigella sp., Acinetobacter sp., Klebsiella sp., and Bacteroides sp.
  • In severe acne, adjunctive therapy with tetracycline may be useful.

When penicillin is contraindicated, tetracyclines are alternative drugs in the treatment of the following infections:

  • syphilis and yaws caused by Treponema pallidumand pertenue, respectively,
  • Vincent’s infection caused by Fusobacterium fusiforme,
  • infections caused by Neisseria gonorrhoeae,
  • anthrax caused by Bacillus anthracis,
  • infections due to Listeria monocytogenes,
  • actinomycosis caused by Actinomyces species,
  • infections due to Clostridium species.

TETRACYCLINE NEWS HIGHLIGHTS

Published Studies Related to Tetracycline

The effect of EDTA, EGTA, EDTAC, and tetracycline-HCl with and without subsequent NaOCl treatment on the microhardness of root canal dentin. [2007.09]

Topical minocycline and tetracycline rinses in treatment of recurrent aphthous stomatitis: a randomized cross-over study. [2007.05.01]

Calcium loss from root canal dentin following EDTA, EGTA, EDTAC, and tetracycline-HCl treatment with or without subsequent NaOCl irrigation. [2007.05]

Clinical and Microbiological Comparisons of Isotretinoin vs. Tetracycline in Acne Vulgaris. [2007]

Effect of oral aluminium hydroxide on iron absorption from iron(III)-hydroxide polymaltose complex in patients with iron deficiency anemia / a single-centre randomized controlled isotope study. [2007]

more>>

Clinical Trials Related to Tetracycline

A Prospective Clinical Study Assessing the Effects of Tetracycline Antibiotic on Tear Film and Tear Lipid Composition Within a Population of Patients Diagnosed With Blepharitis and Dry Eye Disease [Terminated]

Randomised Double Blind Crossover Placebo Controlled Study to Evaluate the Efficacy of Tetracycline in Epidermolysis Bullosa [Not yet recruiting]

Tetracycline in Preventing Skin Rash in Patients Who Are Receiving Drugs Such as Gefitinib and Cetuximab for Cancer [Recruiting]

Tetracycline (Doxycycline) and Post Myocardial Infarction Remodeling [Recruiting]

Bone Disease in Severely Burned Children [Recruiting]

more>>

Page last updated: 2007-10-18

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