Parenteral administration of tetracaine hydrochloride stabilizes the neuronal membrane and prevents initiation and transmission of nerve impulses thereby effecting local anesthesia.
Tetracaine hydrochloride is indicated for the production of spinal anesthesia for procedures requiring two to three hours.
Published Studies Related to Tetracaine Injection
Lidocaine/tetracaine patch (Rapydan) for topical anaesthesia before arterial
access: a double-blind, randomized trial. 
non-inferior to subcutaneous local anaesthetic... CONCLUSIONS: Both the lidocaine/tetracaine patch and subcutaneous injection of
Clinical efficacy of tetracaine anesthetic paste. 
Benzocaine, the most commonly used topical anesthetic in dentistry, often fails
to eliminate the pain associated with injections. One type of anesthetic used
frequently in medicine with success is tetracaine, but minimal research has been
done regarding the application of tetracaine in dentistry...
Tetracaine (ametop) compared to placebo for reducing pain associated with intramuscular injection of palivizumab (synagis). [2009.12]
Infants receive many painful immunizations before they are 2 years old. The purpose of this study was to evaluate if topical tetracaine reduces the pain of intramuscular palivizumab compared to placebo...
Clinical Trials Related to Tetracaine Injection
Tetracaine Compared to Placebo for Reducing Pain With Palivizumab - A Pilot Study [Completed]
This is a small study known as a pilot study. This pilot study is being done to see if a
difference in pain from intramuscular palivizumab injection can be detected if tetracaine a
topical numbing gel is used compared to no medication (placebo). If a difference is found in
this pilot study, then a larger study may be done to confirm that there is a difference in
Tetracaine Versus Lidocaine Gel for Anesthetic Effect and Comfort in Patients Undergoing LASIK [Terminated]
In this study the investigators will be comparing two different types of anesthetic, a
numbing eye drop and a numbing gel, to test if they are equally effective or if one has a
better outcome in terms of the level of comfort you experience one hour and one day after
your surgery. The two medications are commonly used and appear to be equally effective for
other types of eye surgery, such as cataract surgery. This study will show if one type of
anesthesia is preferred over another by patients getting LASIK. Before your LASIK procedure,
you will be given a short questionnaire to determine the baseline comfort of your eyes. In
the operating room, one type of anesthetic will be put in one eye, and the other medication
will be put in the other eye. Which anesthetic you get in each eye will be chosen in a
random way (similar to flipping a coin). After your LASIK surgery, the investigators will
ask you if you felt more comfort in your right eye, your left eye, or if they were equal,
and the investigators will ask you the same survey questions that were asked prior to your
LASIK to get more details about your experience.
*Of note- the randomization being done is for which eye will be receiving the lidocaine and
which eye will be receiving the tetracaine. Each patient will receive lidocaine in 1 eye and
tetracaine in the other eye, the randomization is for each individual eye. This means, of 11
patients in our study, 22 eyes received treatment. 11 eyes received lidocaine and 11 eyes
when we did our comparison, 11 values were used for lidocaine and 11 eyes were used for
tetracaine, giving a total of 22 eyes. This is important to note since the randomization
refers to EYE for each individual patient, and not for the patient (ie: participant means 1
eye, not 1 person in the descriptions below).
A Study to Compare the Efficacy of Rapydan Versus Tetracaine Gel [Withdrawn]
Tetracaine gel 4% is a topical anaesthetic gel commonly used in the UK that contains 40 mg
of tetracaine base per gram. Adequate anaesthesia can usually be achieved following a 30
minute application time for venopuncture and a 45 minute application time for venous
cannulation. The hypothesis is that Rapydan medicated plaster is more effective than
tetracaine gel in preventing venous cannulation related pain when applied for the
recommended treatment durations of 30 minutes and 45 minutes respectively.
Effect of Intra-cuff Lidocaine and Tetracaine on Tracheal Tube-induced Emergence Phenomena [Completed]
It has been proven that tracheal tube inflated with lidocaine could decrease the
post-intubation sore throat in nitrous oxide anesthesia. In the study, the investigators
would like to evaluate the effect of lidocaine inflation in non-nitrous oxide anesthesia and
compare the effect of tetracaine, the best mucosal local anesthetics with lidocaine.
Gluing Lacerations Utilizing Epinephrine [Completed]
Minor lacerations are a commonly treated injury in the paediatric emergency department .
Over the past decade, standard closure of these lacerations has evolved from suture repair
to closure with tissue adhesive (also referred to as "skin glue"). Local anaesthetic is not
routinely used during application of skin glue as it was with sutures. There are, however,
several potential advantages to pre-treating wounds with topical LET
(Lidocaine-Epinephrine-Tetracaine), a liquid gel with anaesthetic and vasoconstrictive
properties. Some believe LET can improve patient comfort, increase the ease of glue
application, and lead to better healing when used on lacerations being repaired with tissue
adhesive. This study aims to address the question of whether or not pre-treatment with LET
improves outcomes in minor lacerations repaired with skin glue. The primary hypothesis is
that pre-treatment of minor lacerations with LET will decrease pain (as measured on a Visual
Analog Scale) during repair with tissue adhesive.
Page last updated: 2013-02-10