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Testosterone (Testosterone Cypionate) - Summary

 
 



TESTOSTERONE SUMMARY

TESTOSTERONE ENANTHATE INJECTION USP
FOR INTRAMUSCULAR USE ONLY C-III
Rx only

Testosterone Cypionate Injection for intramuscular injection, contains testosterone cypionate which is the oil-soluble 17 (beta)- cyclopentylpropionate ester of the androgenic hormone testosterone. Testosterone cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils.

Testosterone Cypionate Injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.

  1. Primary hypogonadism (congenital or acquired)-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.

  2. Hypogonadotropic hypogonadism (congenital or acquired)-idiopathic gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.


See all Testosterone indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Testosterone

Phthalates Linked to Testosterone Reductions in Both Genders
Source: Medscape Diabetes & Endocrinology Headlines [2014.08.19]
The findings add to troubling evidence on the adverse reproductive effects of exposure to endocrine-disrupting chemicals.
Medscape Medical News

Common Chemicals May Lower Testosterone Levels, Study Finds
Source: MedicineNet Mens Health Specialty [2014.08.15]
Title: Common Chemicals May Lower Testosterone Levels, Study Finds
Category: Health News
Created: 8/14/2014 2:36:00 PM
Last Editorial Review: 8/15/2014 12:00:00 AM

Technology boom 50,000 years ago correlated with apparent reduction in testosterone
Source: Endocrinology News From Medical News Today [2014.08.05]
Society bloomed with gentler personalities and more feminine facesModern humans appear in the fossil record about 200,000 years ago, but it was only about 50,000 years ago that making art and...

Testosterone Products Must Warn About Risk of Venous Clots: FDA
Source: MedicineNet Deep Vein Thrombosis Specialty [2014.06.23]
Title: Testosterone Products Must Warn About Risk of Venous Clots: FDA
Category: Health News
Created: 6/20/2014 4:35:00 PM
Last Editorial Review: 6/23/2014 12:00:00 AM

Testosterone deficiency can be identified with new screening questionnaire
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today [2014.04.27]
Men whose testosterone falls below normal levels are more likely to have erectile dysfunction and to be overweight and have heart disease and type 2 diabetes.

more news >>

Published Studies Related to Testosterone

A new combination of testosterone and nestorone transdermal gels for male hormonal contraception. [2012]
alone or combined with NES gel in suppressing spermatogenesis... CONCLUSION: A combination of daily NES+T gels suppressed sperm concentration to 1

Efficacy and safety of testosterone in the management of hypoactive sexual desire disorder in postmenopausal women. [2012]
Health... CONCLUSION: Transdermal testosterone appears to be an effective and safe therapy

A placebo-controlled, randomized clinical trial using testosterone undecanoate with injectable norethisterone enanthate: effect on anthropometric, metabolic and biochemical parameters. [2011.12]
Testosterone administered alone or in combination with progestogens in male contraception induces reversible oligo-azoospermia, but its effects on body composition and metabolism are less known. We analysed anthropometric and metabolic parameters in five groups of 10 males: four receiving testosterone undecanoate (TU: 1000 mg) plus norethisterone enanthate (NETE: 200 mg) at different intervals (every 8 weeks: NETE-8; every 12 weeks: NETE-12; every 6 weeks for 12 weeks and then every 12 weeks: NETE-6/12; every 6 weeks for 12 weeks and then TU plus placebo every 12 weeks : NETE-6/12/0) and one placebo (NETE-0/0) for a total of 48 weeks.

A randomized, double-blind, placebo-controlled trial on the effect of long-acting testosterone treatment as assessed by the Aging Male Symptoms scale. [2011.11.17]
Study Type - Therapy (RCT) Level of Evidence 1b What's known on the subject? and What does the study add? Testosterone deficiency syndrome can be treated with testosterone replacement in the form of injectable, transdermal, buccal and oral preparations. Long-acting i.m. testosterone undecanoate 1000 mg, which is given at 10-14 week intervals, has been shown to be adequate for sustaining normal testosterone levels in hypogonadal men. This study confirms that long-acting i.m. testosterone undecanoate is effective in improving the health-related quality of life in men with testosterone deficiency syndrome as assessed by the improvement in the Aging Male Symptoms scale. Testosterone treatment can be indicated in men who have poor health-related quality of life resulting from testosterone deficiency syndrome. OBJECTIVE: * To evaluate the effect of i.m. injection of testosterone undecanoate 1000 mg over 12 months on the Aging Male Symptom (AMS) scale scores in men with testosterone deficiency syndrome (TDS)... CONCLUSION: * Long-acting testosterone is effective in improving health-related quality of life as assessed by the AMS scale in men with TDS. (c) 2011 THE AUTHORS. BJU INTERNATIONAL (c) 2011 BJU INTERNATIONAL.

A randomized pilot study of monthly cycled testosterone replacement or continuous testosterone replacement versus placebo in older men. [2011.11]
Context: Cycling androgens has been reported by athletes to improve physical performance by enhancing muscle mass and strength, a paradigm that has not been studied, and may have clinical value in older men being treated with testosterone... Conclusions: Cycled testosterone improved body composition and increased muscle strength compared with placebo and increased FSR similarly to continuous testosterone.

more studies >>

Clinical Trials Related to Testosterone

A Study of Fortigel Testosterone Gel 2% in Males With Low Testosterone [Active, not recruiting]
Low testosterone is a condition that occurs when the body is unable to produce sufficient quantities of testosterone. The medical name for low testosterone is hypogonadism. Hypogonadism can be caused by many factors. Symptoms include: decrease in libido, lack of energy and mood swings. The goal of testosterone replacement therapy is to return testosterone levels to the normal range and relieve symptoms.

The purpose of this study is to evaluate the ability of Fortigel testosterone gel 2% to maintain serum (blood) testosterone levels within the normal range in hypogonadal men aged 18 to 75 years. This will be determined by blood sampling at specified times during the study. The study is also intended to evaluate the tolerability of Fortigel, which will be applied to the skin each day throughout the study period.

Study On Bioavailability And Pharmacokinetics Of Various Doses Of Testosterone Administered With And Without Dutasteride [Completed]
The combination of testosterone and dutasteride is intended for use in hypogonadal men. This study will evaluate the bioavailability and pharmacokinetics of various doses of testosterone administered with and without dutasteride

Study of The Effects of Testosterone in Frail Elderly Men [Completed]

Testosterone for HIV-Positive Men With Reduced Serum Testosterone Levels and Abdominal Fat [Completed]
The purpose of this study is to see if treatment with testosterone will reduce abdominal fat in HIV-positive men.

Many HIV patients on antiretroviral therapy show an increase in abdominal fat. Studies have shown that treatment with testosterone may decrease abdominal fat. This study will determine if testosterone will reduce abdominal fat in HIV patients.

28-Day Study of Testosterone Co-Administered With Dutasteride in Hypogonadal Men [Terminated]
The combination of testosterone and dutasteride is intended for use in hypogonadal men. This study will evaluate the effect of 28-day repeat dosing of this combination with varying BID doses of testosterone (T), in combination with a fixed BID dose of dutasteride (D), as well as a testosterone alone arm, on T and D levels in the blood. The rationale is to look for the effects of each compound on the other, and to look for any safety problems that may result when the 2 drugs are given together.

more trials >>

Reports of Suspected Testosterone Side Effects

Drug Ineffective (56)Blood Testosterone Decreased (21)Drug Administered AT Inappropriate Site (19)Fatigue (15)Accidental Exposure (15)Blood Testosterone Increased (14)Asthenia (14)Pulmonary Embolism (12)Headache (12)Alopecia (12)more >>


Page last updated: 2014-08-19

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