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Testosterone (Testosterone Cypionate) - Summary

 
 



TESTOSTERONE SUMMARY

TESTOSTERONE ENANTHATE INJECTION USP
FOR INTRAMUSCULAR USE ONLY C-III
Rx only

Testosterone Cypionate Injection for intramuscular injection, contains testosterone cypionate which is the oil-soluble 17 (beta)- cyclopentylpropionate ester of the androgenic hormone testosterone. Testosterone cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils.

Testosterone Cypionate Injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.

  1. Primary hypogonadism (congenital or acquired)-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.

  2. Hypogonadotropic hypogonadism (congenital or acquired)-idiopathic gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.


See all Testosterone indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Testosterone

No Prostate Cancer Risk With Testosterone for Hypogonadism
Source: Medscape Diabetes & Endocrinology Headlines [2014.12.10]
New registry data should help reassure doctors that using testosterone therapy for hypogonadism does not increase the risk for prostate cancer, say German researchers.
Medscape Medical News

Long-term testosterone therapy does not increase the risk of prostate cancer
Source: Endocrinology News From Medical News Today [2014.11.28]
Testosterone (T) therapy is routinely used in men with hypogonadism, a condition in which diminished function of the gonads occurs.

Testosterone surges in athletes not tied to winning
Source: Endocrinology News From Medical News Today [2014.11.28]
A higher surge of testosterone in competition, the so-called "winner effect," is not actually related to winning, suggests a new study of intercollegiate cross country runners.

Testosterone Plays Minor Role in Older Women's Sex Lives, Study Finds
Source: MedicineNet Menopause Specialty [2014.11.21]
Title: Testosterone Plays Minor Role in Older Women's Sex Lives, Study Finds
Category: Health News
Created: 11/20/2014 12:00:00 AM
Last Editorial Review: 11/21/2014 12:00:00 AM

Testosterone replacement therapy not found to increase men's cardiovascular risks
Source: Endocrinology News From Medical News Today [2014.11.20]
An important new study of men who have undergone testosterone replacement therapy has found that taking supplemental testosterone does not increase their risk of experiencing a major adverse cardiac...

more news >>

Published Studies Related to Testosterone

Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point. [2014]
hematocrit remain unclear... CONCLUSIONS: Testosterone-induced increase in hemoglobin and hematocrit is

The role of androgen receptor CAG repeat polymorphism and other factors which affect the clinical response to testosterone replacement in metabolic syndrome and type 2 diabetes: TIMES2 sub-study. [2013]
TRT in the TIMES2 study... CONCLUSION: AR CAG affected the response of some variables to TRT in the TIMES2

Mechanical muscle function and lean body mass during supervised strength training and testosterone therapy in aging men with low-normal testosterone levels. [2013]
24-week study... CONCLUSION: Strength training in aging men with low-normal testosterone levels

Pharmacokinetics of testosterone and estradiol gel preparations in healthy young men. [2013]
The paucity of pharmacokinetic data on testosterone gel formulations and absence of such data on estradiol administration in healthy young men constitutes a fundamental gap of knowledge in behavioral endocrinological research. We addressed this issue in a double-blind and placebo controlled study in which we applied a topical gel containing either 150mg of testosterone (N=10), 2mg of estradiol (N=8) or a respective placebo (N=10) to 28 healthy young men...

A new combination of testosterone and nestorone transdermal gels for male hormonal contraception. [2012]
alone or combined with NES gel in suppressing spermatogenesis... CONCLUSION: A combination of daily NES+T gels suppressed sperm concentration to 1

more studies >>

Clinical Trials Related to Testosterone

A Study of Fortigel Testosterone Gel 2% in Males With Low Testosterone [Active, not recruiting]
Low testosterone is a condition that occurs when the body is unable to produce sufficient quantities of testosterone. The medical name for low testosterone is hypogonadism. Hypogonadism can be caused by many factors. Symptoms include: decrease in libido, lack of energy and mood swings. The goal of testosterone replacement therapy is to return testosterone levels to the normal range and relieve symptoms.

The purpose of this study is to evaluate the ability of Fortigel testosterone gel 2% to maintain serum (blood) testosterone levels within the normal range in hypogonadal men aged 18 to 75 years. This will be determined by blood sampling at specified times during the study. The study is also intended to evaluate the tolerability of Fortigel, which will be applied to the skin each day throughout the study period.

Study On Bioavailability And Pharmacokinetics Of Various Doses Of Testosterone Administered With And Without Dutasteride [Completed]
The combination of testosterone and dutasteride is intended for use in hypogonadal men. This study will evaluate the bioavailability and pharmacokinetics of various doses of testosterone administered with and without dutasteride

Study of The Effects of Testosterone in Frail Elderly Men [Completed]

Testosterone for HIV-Positive Men With Reduced Serum Testosterone Levels and Abdominal Fat [Completed]
The purpose of this study is to see if treatment with testosterone will reduce abdominal fat in HIV-positive men.

Many HIV patients on antiretroviral therapy show an increase in abdominal fat. Studies have shown that treatment with testosterone may decrease abdominal fat. This study will determine if testosterone will reduce abdominal fat in HIV patients.

28-Day Study of Testosterone Co-Administered With Dutasteride in Hypogonadal Men [Terminated]
The combination of testosterone and dutasteride is intended for use in hypogonadal men. This study will evaluate the effect of 28-day repeat dosing of this combination with varying BID doses of testosterone (T), in combination with a fixed BID dose of dutasteride (D), as well as a testosterone alone arm, on T and D levels in the blood. The rationale is to look for the effects of each compound on the other, and to look for any safety problems that may result when the 2 drugs are given together.

more trials >>

Reports of Suspected Testosterone Side Effects

Drug Ineffective (56)Blood Testosterone Decreased (21)Drug Administered AT Inappropriate Site (19)Fatigue (15)Accidental Exposure (15)Blood Testosterone Increased (14)Asthenia (14)Pulmonary Embolism (12)Headache (12)Alopecia (12)more >>


Page last updated: 2014-12-10

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