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Terrell (Isoflurane) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

DRUG INTERACTIONS

Isoflurane potentiates themuscle relaxant effect of all muscle relaxants, most notably nondepolarizingmuscle relaxants, and MAC (minimum alveolar concentration) is reduced byconcomitant administration of N2O. (See CLINICAL PHARMACOLOGY).

OVERDOSAGE

In the event ofoverdosage, or what may appear to be overdosage, the following action should betaken:


Stop drug administration, establish a clear airway and initiate assistedor controlled ventilation with pure oxygen.

CONTRAINDICATIONS

Known sensitivity to isofluraneor to other halogenated agents.

Knownor suspected genetic susceptibility to malignant hyperthermia.

Storage

Store at room temperature15 ° to 30°C (59 to 86°F). Isoflurane, contains noadditives and has been demonstrated to be stable at room temperature forperiods in excess of five years.

REFERENCES

  1. J.C. Sill, et al, Anesthesiology 66:273-279, 1987
  2. R.F. Hickey, et al, Anesthesiology 68:21-30, 1988
  3. C.W. Buffington, et a l, Anesthesiology 66:280-292, 1987
  4. S. Reiz, et al, Anesthesiology 59:91-97, 1983
  5. S. Slogoff and A.S. Keats, Anesthesiology 70:179-188, 1989
  6. K.J. Tuman, et al, Anesthesiology 70:189-198, 1989
  7. D.T. Mangano, Editorial Views, Anesthesiology 70:175-178, 1989

Manufacturer

Manufactured By:

Piramal CriticalCare, Inc.

3950 Schelden Circle

Bethlehem, PA 18017

(888) 822-8431


© 2010 PiramalCritical Care, Inc.

AWN-34112002

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