Terramycin® (oxytetracycline HCl)
—Cortril® (hydrocortisone acetate)
Terra-Cortril suspension combines the antibiotic, oxytetracycline HCl (C22H24N2O9•HCl) and the adrenocorticoid, hydrocortisone acetate (C23H32O6). Each ml of Terra-Cortril contains Terramycin (oxytetracycline HCl) equivalent to 5 mg of oxytetracycline, and 15 mg of Cortril (hydrocortisone acetate) incorporated in mineral oil with aluminum tristearate. For Ophthalmic Use Only.
For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial ocular infection exists.
Ocular steroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe where the inherent risk of steroid use in certain infective conjunctivitides is accepted to obtain a diminution in edema and inflammation. They are also indicated in chronic anterior uveitis and corneal injury from chemical radiation, thermal burns, or penetration of foreign bodies.
The use of a combination drug with an anti-infective component is indicated where the risk of infection is high or where there is an expectation that potentially dangerous numbers of bacteria will be present in the eye.
The particular anti-infective drug in this product is active against the following common bacterial eye pathogens:
- Staphylococcus aureus
- Streptococci, including Streptococcus pneumoniae
- Escherichia coli
- Neisseria species
The product does not provide adequate coverage against:
- Haemophilus influenzae
- Klebsiella/Enterobacter species
- Pseudomonas aeruginosa
- Serratia marcescens
Published Studies Related to Terra-Cortril (Oxytetracycline / Hydrocortisone Ophthalmic)
Otitis externa: clinical comparison of local ciprofloxacin versus local oxytetracycline, polymyxin B, hydrocortisone combination treatment. 
Thirty patients with otitis externa were included in a prospective, randomized, parallel group comparison study. Treatment regimens used were ciprofloxacin (2 mg/ml) as ear drops twice daily or drops containing oxytetracycline (5 mg/ml) polymyxin B (10,000 units/ml) and hydrocortisone (15 mg/ml) twice daily for 7 days...
A clinical comparison of hydrocortisone butyrate with oxytetracycline/hydrocortisone acetate-polymyxin B in the local treatment of acute external otitis. 
In a single blind, randomized study, 46 patients with acute external otitis were treated with either oxytetracycline/hydrocortisone with polymyxin B (TPB) or hydrocortisone-17-alpha-butyrate eardrops for 7 days...
Clinical Trials Related to Terra-Cortril (Oxytetracycline / Hydrocortisone Ophthalmic)
Septic Shock em Steroids [Recruiting]
Septic shock is a frequent reason for admission on pediatric intensive care units.
Interventions which can change morbidity and mortality of septic shock patients are of great
interest. Steroid replacement in adults with severe sepsis and septic shock have been
extensively studied. It was recently demonstrated that low dose steroid (< 300mg/ day) used
for more than 5 days was associated with decreased mortality and lower requirement of
vasoactive support in the adult population that had a low response to the ACTH test.
However, this was not confirmed in the latest results from the CORTICUS study. Use of low
dose hydrocortisone, or any other steroid has not been studied in critically ill children.
Mortality associated with sepsis in children has decreased in the last decade and currently
it is close to 10%, making it difficult to power a study able to show reduced mortality.
Taking into account the results from previous studies reporting the high incidence of
adrenal failure and its association to worse outcome, we have designed a clinical trial to
evaluate the effect of low dose hydrocortisone in children with septic shock: Cortisol
Replacement in Children with Sepsis Study.
Page last updated: 2006-01-31