NEWS HIGHLIGHTS
Published Studies Related to Terbutaline
Continuous infusions of terbutaline in asthma - a review. [2011.10]
CONCLUSION: Although some findings are encouraging, they are drawn from small observational studies done at a time when the standard management of asthma was quite different from today. No randomized controlled trials exist for the use of CSIT, which remains off-license for the treatment of asthma in the United Kingdom. Clearly, prospective well-powered studies are required to fully ascertain its potential benefits and safety profile-something that is unlikely to occur given that the use of CSIT remains low and appears to be declining.
Improvement of fertility in artificially inseminated ewes following vaginal treatment with misoprostol plus terbutaline sulphate. [2010.12]
The effect of vaginal administration of misoprostol plus terbutaline sulphate 6 h prior to artificial insemination (AI) upon the site of AI (vaginal or cervical) and fertility was studied using a total of 87 estrous synchronized Serra da Estrela ewes (control n = 42 and treated n = 45)... Although needing confirmation, it was hypothesized that drugs might have induced local secretory modifications leading to an increase of cervical ability to retain more viable spermatozoa for fertilization.
The effect of terbutaline on the absorption of pulmonary administered insulin in subjects with asthma. [2010.03]
AIM: To investigate the effect of prior administration of a bronchodilator on the absorption of inhaled insulin in people with asthma treated with inhaled corticosteroids... CONCLUSIONS: In people with asthma and reversible bronchoconstriction, the administration of a bronchodilator prior to administration of inhaled insulin led to increased absorption of insulin, whereas no effect on insulin absorption in subjects without significant reversibility could be detected.
Bromotyrosines in sputum proteins and treatment effects of terbutaline and budesonide in asthma. [2009.10]
BACKGROUND: Inhaled corticosteroids are widely used in the treatment of persistent asthma, usually combined with inhaled beta2-agonists. Previous research suggests that short-acting beta2-agonists (SABAs) may downregulate the anti-inflammatory effects of inhaled corticosteroids, thereby increasing asthma morbidity. OBJECTIVE: To determine whether 3-bromotyrosine and 3,5-dibromotyrosine levels, specific markers of eosinophil activation, reflect treatment effects on airway inflammation of inhaled corticosteroids and SABAs and support previous conclusions... CONCLUSIONS: 3-Bromotyrosine and 3,5-dibromotyrosine levels reflect treatment effects in asthma and support previous findings that SABAs impair the anti-inflammatory effects of inhaled corticosteroids. In addition to eosinophil numbers and eosinophil cationic protein levels, these modified tyrosine residues provide useful information about the inflammatory state of the airways.
A randomized, controlled trial of nebulized terbutaline for the first acute bronchiolitis in infants less than 12-months-old. [2009.03]
BACKGROUND: Despite the common clinical practice, the available evidence on the efficacy of bronchodilators therapy for bronchiolitis is conflicting. The aim of this study is to evaluate the efficacy of nebulized terbutaline in bronchiolitis as measured by improvement in clinical score, oxygen saturation or reduction in duration of hospitalization... CONCLUSION: Nebulized terbutaline therapy does not appear effective in treating moderately ill infants with the first acute bronchiolitis.
Clinical Trials Related to Terbutaline
Terbutaline Concentrations in Blood and Urine [Not yet recruiting]
The purpose of this study is to assess the blood and urine concentrations of terbutaline and
to evaluate the difference between inhaled and oral terbutaline in order to distinguish
treatment with terbutaline from doping with terbutaline in a doping control.
Prn Budesonide/Formoterol Versus Regular Budesonide/Formoterol Plus Prn Terbutaline in Mild-Moderate Asthma [Recruiting]
Study No. 001 about Budesonide/Formoterol use in ASthMA sponsored by Agenzia Italiana del
FArmaco (Italian Drug Agency) (AIFA-ASMA-BF-001) The aim of the study is to verify whether
asthma not controlled by low doses inhaled corticosteroids, thus in need for step up
therapy, can be equally controlled by guidelines recommended regular bid treatment with long
acting beta agonist/inhaled corticosteroid (ICS/LABA) combination or the symptom driven use
of an ICS/LABA combination in the absence of maintenance therapy. The study is designed to
be able to evaluate the non inferiority of regular placebo plus prn inhaled
budesonide/formoterol (experimental treatment) versus regular, twice daily 160/4. 5 mcg
inhaled budesonide/formoterol combination plus prn inhaled terbutaline (guidelines
recommended treatment).
Comparing Symbicort As-Needed or Bricanyl As-Needed or Pulmicort Once Daily + Bricanyl As-Needed in Asthma Patients [Not yet recruiting]
1. The primary objective of this study is:
- To evaluate the magnitude of the protective effect of the combination of
budesonide and formoterol on an as-needed basis compared to the use of terbutaline
as-needed on exercise induced bronchoconstriction in adults and adolescents with
mild intermittent asthma
2. The secondary objectives of this study are:
- To evaluate the magnitude of the protective effect of the combination of
budesonide and formoterol as-needed compared to regular once daily use of
budesonide plus terbutaline as-needed on exercise induced bronchoconstriction in
adults and adolescents with mild intermittent asthma
- To evaluate safety of budesonide/formoterol as-needed, terbutaline as-needed and
regular use of budesonide + terbutaline as-needed as terms of adverse event
Intravenous Terbutaline to Facilitate Labor Epidural Catheter Placement [Not yet recruiting]
Labor pain is a major factor in making the placement of an epidural catheter difficult. The
epidural, once in place and dosed, eventually decreases the parturient's pain. To achieve
this goal as fast and safely as possible it would be helpful to have a parturient who can
tolerate and co-operate with the placement of the epidural catheter.
Briefly stopping contractions, the cause of labor pain, could be the key to achieve this
goal.
This study will evaluate the safety, efficacy and duration of the drug terbutaline for this
purpose.
Study to Investigate the Efficacy of Symbicort SMART. [Recruiting]
The primary objective of this study is to compare the efficacy of Symbicort SMART
(Symbicort Turbuhaler 160/4. 5μg, one inhalation bid plus as needed) with Symbicort
Turbuhaler 160/4. 5μg, one inhalation bid plus terbutaline Turbuhaler 0. 4 mg as needed, as
asthma therapy
Reports of Suspected Terbutaline Side Effects
Maternal Exposure During Pregnancy (12),
Lactic Acidosis (7),
Attention Deficit/hyperactivity Disorder (6),
Gastrooesophageal Reflux Disease (5),
Cleft LIP and Palate (5),
Asthma (4),
Chorioamnionitis (4),
Congenital Central Nervous System Anomaly (4),
Developmental Delay (4),
Patent Ductus Arteriosus (4), more >>
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