Tenormin (Atenolol) - Summary

TENORMIN SUMMARY

TENORMIN® (atenolol), a synthetic, beta₁-selective (cardioselective) adrenoreceptor blocking agent.

Hypertension: TENORMIN is indicated in the management of hypertension. It may be used alone or concomitantly with other antihypertensive agents, particularly with a thiazide-type diuretic.

Angina Pectoris Due to Coronary Atherosclerosis: TENORMIN is indicated for the long-term management of patients with angina pectoris.

Acute Myocardial Infarction: TENORMIN is indicated in the management of hemodynamically stable patients with definite or suspected acute myocardial infarction to reduce cardiovascular mortality. Treatment can be initiated as soon as the patient's clinical condition allows. (See DOSAGE AND ADMINISTRATION, CONTRAINDICATIONS, and WARNINGS.) In general, there is no basis for treating patients like those who were excluded from the ISIS-1 trial (blood pressure less than 100 mm Hg systolic, heart rate less than 50 bpm) or have other reasons to avoid beta blockade. As noted above, some subgroups (eg, elderly patients with systolic blood pressure below 120 mm Hg) seemed less likely to benefit.

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TENORMIN NEWS HIGHLIGHTS

Published Studies Related to Tenormin (Atenolol)

Verapamil-sustained release-based treatment strategy is equivalent to atenolol-based treatment strategy at reducing cardiovascular events in patients with prior myocardial infarction: an INternational VErapamil SR-Trandolapril (INVEST) substudy. [2008.08]

The relationship between the plasma concentration of irbesartan and the antihypertensive response is disclosed by an angiotensin II type 1 receptor polymorphism: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs. Atenolol (SILVHIA) Trial. [2008.07]

Economic evaluation of ASCOT-BPLA: antihypertensive treatment with an amlodipine-based regimen is cost effective compared with an atenolol-based regimen. [2008.02]

Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension. [2007.10]

An economic assessment of losartan-based versus atenolol-based therapy in patients with hypertension and left-ventricular hypertrophy: results from the Losartan Intervention For Endpoint reduction (LIFE) study adapted to The Netherlands. [2007.05]

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Clinical Trials Related to Tenormin (Atenolol)

A Randomized, Open-Label, LOSARTAN Therapy on the Progression of Aortic Root Dilation in Patients With Marfan Syndrome [Enrolling by invitation]

Effects of Losartan Versus Atenolol on Aortic and Cardiac Muscle Stiffness in Adults With Marfan Syndrome [Recruiting]

VALENCE: Valsartan Versus Atenolol on Exercise Capacity in Hypertensive Overweight Postmenopausal Women [Completed]

Perioperative Effect of Atenolol on Cytokine Profiles [Active, not recruiting]

A Pilot Study Comparing Nebivolol and Atenolol and Its Effects With Exercise in Patients With Mild to Moderate Hypertension [Completed]

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TENORMIN PATIENT REVIEWS / RATINGS / COMMENTS

Tenormin review by 35 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		Tachycardia
Dosage & duration:		25 mg taken twice per day for the period of 12 years
Other conditions:		Type I Diabetes, Depression, Panic Disorder
Other drugs taken:		Insulin, Xanax, Klonopin, varying Anti-Depressants
		Reported Results
Benefits:		The benefits were immediate relief from a "racing heart" or tachycardia caused by anxiety. I use this medicine prophylactically and found that it is very effective in controlling my heart rate and keeping it within a normal range. The only time it does not work is if I have a full-blown panic attack. At that point, other types of medications are used in addition to the atenolol.
Side effects:		The side effects were mild but it did slightly lower my ability to determine if I was having an insulin reaction (hypoglycemia). However, once I adjusted to the medication, it was not a problem.
Comments:		Treatment was started immediately after an initial and severe case of tachycardia. An Echocardiogram ruled out any heart defect and I was started on 25 mg once per day. I stayed on this dose for about 6 years and was able to drop down to 12.5 mg per day for nearly a year. However, my symptoms returned to their original severity and I began taking my starting dose again. A few years later, I was prescribed 25 mg twice per day due to an increase from original symptoms. This is the dose I currently take and it is an effective and very affordable medication.

Tenormin review by 56 year old female patient
		Rating
Overall rating:
Effectiveness:		Marginally Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		hypertension
Dosage & duration:		50 mg/daily taken x1/day for the period of 3 yrs
Other conditions:		SOB
Other drugs taken:		hydrochlorathyazide
		Reported Results
Benefits:		Slowed heart rate, lowered blood pressure and helped eliminate head-aches that I atributed to increasing BP.
Side effects:		I believe that I have gained weight due to taking BP medication. I feel that my metabolic rate has been affected by these meds.
Comments:		BP meds are taken on a daily basis, and I try to take the meds at the same time each day. I do not take these meds on a with or w/o food timetable.

Tenormin review by 56 year old female patient
		Rating
Overall rating:
Effectiveness:		Marginally Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		hypertension
Dosage & duration:		50 mg/daily taken x1/day for the period of 3 yrs
Other conditions:		SOB
Other drugs taken:		hydrochlorathyazide
		Reported Results
Benefits:		Slowed heart rate, lowered blood pressure and helped eliminate head-aches that I atributed to increasing BP.
Side effects:		I believe that I have gained weight due to taking BP medication. I feel that my metabolic rate has been affected by these meds.
Comments:		BP meds are taken on a daily basis, and I try to take the meds at the same time each day. I do not take these meds on a with or w/o food timetable.