TEMOVATE SUMMARY
TEMOVATE E® (clobetasol propionate emollient cream) Emollient, 0.05%
TEMOVATE (clobetasol propionate cream and ointment) Cream and Ointment contain the active compound clobetasol propionate, a synthetic corticosteroid, for topical dermatologic use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.
TEMOVATE Cream and Ointment are super-high potency corticosteroid formulations indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Treatment beyond 2 consecutive weeks is not recommended, and the total dosage should not exceed 50 g/week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis. Use in pediatric patients under 12 years of age is not recommended.
As with other highly active corticosteroids, therapy should be discontinued when control has been achieved. If no improvement is seen within 2 weeks, reassessment of the diagnosis may be necessary.
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NEWS HIGHLIGHTSMedia Articles Related to Temovate (Clobetasol Topical)
EU Approves Dupilumab (Dupixent) for Atopic Dermatitis Source: Medscape Allergy & Clinical Immunology Headlines [2017.09.28] The European Commission has granted marketing authorization to dupilumab for adults with moderate to severe atopic dermatitis, according to a company news release. International Approvals
Atopic Eczema (Atopic Dermatitis) Quiz: Test Your Skin Disorders IQ Source: MedicineNet Atopic Dermatitis Specialty [2017.09.20] Title: Atopic Eczema (Atopic Dermatitis) Quiz: Test Your Skin Disorders IQ Category: MedicineNet Quiz Created: 3/20/2012 12:50:00 PM Last Editorial Review: 9/20/2017 12:22:53 PM
Seborrheic Dermatitis Source: MedicineNet Eye Care Specialty [2017.08.09] Title: Seborrheic Dermatitis Category: Diseases and Conditions Created: 3/16/2012 12:00:00 AM Last Editorial Review: 8/9/2017 12:00:00 AM
Contact Dermatitis Source: MedicineNet hydrocortisone valerate Specialty [2017.06.09] Title: Contact Dermatitis Category: Symptoms and Signs Created: 4/1/2014 12:00:00 AM Last Editorial Review: 6/9/2017 12:00:00 AM
Atopic Dermatitis Source: MedicineNet betamethasone dipropionate Specialty [2016.12.21] Title: Atopic Dermatitis Category: Diseases and Conditions Created: 12/31/1997 12:00:00 AM Last Editorial Review: 12/21/2016 12:00:00 AM
Published Studies Related to Temovate (Clobetasol Topical)
Clobetasol propionate, 0.05%, vs hydrocortisone, 1%, for alopecia areata in
children: a randomized clinical trial. [2014] IMPORTANCE: Alopecia areata is an idiopathic cause of hair loss with limited
therapeutic repertoire. OBJECTIVE: To compare the efficacy and safety of a high- vs low-potency topical
corticosteroid in pediatric patients...
A comparative study in efficacy and safety of 0.1% tacrolimus and 0.05%
clobetasol propionate ointment in discoid lupus erythematosus by modified
cutaneous lupus erythematosus disease area and severity index. [2012] CONCLUSION: The present study proved the efficacy of twice-daily tacrolimus and
A double-blind, randomized, placebo-controlled trial of topical tacrolimus 0.1% vs. clobetasol propionate 0.05% in childhood vitiligo. [2011.09] BACKGROUND: Both clobetasol propionate 0.05% (CP 0.05%) and tacrolimus 0.1% (T 0.1%) ointments have been shown to be efficacious and safe in treating vitiligo in the paediatric population. OBJECTIVES: To assess efficacy and safety of these two therapies compared with each other and with placebo... CONCLUSIONS: Both CP 0.05% and T 0.1% ointments offer similar benefit in paediatric vitiligo, both facial and nonfacial. The facial lesions responded faster than the nonfacial ones. (c) 2011 The Authors. BJD (c) 2011 British Association of Dermatologists.
Clobetasol propionate 0.05% spray for the management of moderate-to-severe plaque psoriasis of the scalp: results from a randomized controlled trial. [2011.08] BACKGROUND: Clobetasol propionate 0.05% spray is available for treating moderate-to-severe plaque psoriasis; however, there is limited information with plaque psoriasis of the scalp. OBJECTIVE: Evaluate the efficacy, safety, and quality-of-life impact of clobetasol propionate 0.05% spray in patients with moderate to severe plaque psoriasis of the scalp... CONCLUSION: Treatment with clobetasol propionate 0.05% spray for up to four weeks is effective and well tolerated for moderate-to-severe plaque psoriasis of the scalp.
Comparison of clobetasol propionate cream plus coal tar vs. topical psoralen and solar ultraviolet A therapy in palmoplantar psoriasis. [2011.08] AIM: Palmoplantar psoriasis (PPP) produces significant morbidity and requires prompt treatment. Topical agents form the mainstay of therapy. We compared the efficacy and side-effect profile of a steroid/coal-tar combination with topical psoralen and solar ultraviolet A (PUVAsol) in PPP... CONCLUSION: Both treatments had comparable efficacy. In both groups, patients experienced 'good improvement' after 16 weeks of therapy. (c) The Author(s). CED (c) 2011 British Association of Dermatologists.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 2 ratings/reviews, Temovate has an overall score of 7. The effectiveness score is 6 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
| Temovate review by 46 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Moderately Effective |
Side effects: | | No Side Effects | | Treatment Info |
Condition / reason: | | dyshidrosis |
Dosage & duration: | | twice daily (dosage frequency: twice daily) for the period of two weeks |
Other conditions: | | noce |
Other drugs taken: | | None | | Reported Results |
Benefits: | | The resulting small, fluid-filled blisters (vesicles) most commonly occur on the palms and fingers of your hands and on the soles and toes of your feet. The blisters usually last for three to four weeks.
The blisters often cause intense itching. Scratching the blisters can damage the skin and, in some cases, lead to infection. Once the blisters dry, they often leave cracks and painful grooves (fissures) in your skin.
Risk factors
Dyshidrosis occurs twice as often in women as in men. Other risk factors include:
* Stress, because dyshidrosis appears to be more common during times of stress
* Exposure to metal salts, such as chromium, cobalt and nickel — usually through cement or mechanical work
* Having seasonal allergies, such as hay fever
* Frequently exposing your skin to water or other wet substances
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Side effects: | | The resulting small, fluid-filled blisters (vesicles) most commonly occur on the palms and fingers of your hands and on the soles and toes of your feet. The blisters usually last for three to four weeks.
The blisters often cause intense itching. Scratching the blisters can damage the skin and, in some cases, lead to infection. Once the blisters dry, they often leave cracks and painful grooves (fissures) in your skin.
Risk factors
Dyshidrosis occurs twice as often in women as in men. Other risk factors include:
* Stress, because dyshidrosis appears to be more common during times of stress
* Exposure to metal salts, such as chromium, cobalt and nickel — usually through cement or mechanical work
* Having seasonal allergies, such as hay fever
* Frequently exposing your skin to water or other wet substances
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Comments: | | The resulting small, fluid-filled blisters (vesicles) most commonly occur on the palms and fingers of your hands and on the soles and toes of your feet. The blisters usually last for three to four weeks.
The blisters often cause intense itching. Scratching the blisters can damage the skin and, in some cases, lead to infection. Once the blisters dry, they often leave cracks and painful grooves (fissures) in your skin.
Risk factors
Dyshidrosis occurs twice as often in women as in men. Other risk factors include:
* Stress, because dyshidrosis appears to be more common during times of stress
* Exposure to metal salts, such as chromium, cobalt and nickel — usually through cement or mechanical work
* Having seasonal allergies, such as hay fever
* Frequently exposing your skin to water or other wet substances
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| Temovate review by 49 year old male patient | | Rating |
Overall rating: | | |
Effectiveness: | | Moderately Effective |
Side effects: | | No Side Effects | | Treatment Info |
Condition / reason: | | Dyshidrosis |
Dosage & duration: | | 0.05% (dosage frequency: 2x per day) for the period of 2 weeks |
Other conditions: | | None |
Other drugs taken: | | None | | Reported Results |
Benefits: | | reduced symptoms after using the cream for a total of two months. |
Side effects: | | There were no apparent side effect from using this treatment. |
Comments: | | cream applied twice per day for two weeks. one week without treatment and than two weeks on the treatment. Repeat this regiment until symptoms are reduced or disappear. |
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Page last updated: 2017-09-28
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