DOSAGE AND ADMINISTRATION
The recommended once-daily doses of Tekturna HCT in order of increasing mean effect are 150/12.5 mg, 150/25 mg or 300/12.5 mg, and 300/25 mg.
Regardless of the dose of the single agent, patients switched from monotherapy to Tekturna HCT will experience greater blood pressure reductions with use of the combination product.
The antihypertensive effect of Tekturna HCT is largely manifested within 1 week, with maximal effects generally seen at around 4 weeks. If blood pressure remains uncontrolled after 2 to 4 weeks of therapy, the dose may be titrated up to a maximum of aliskiren 300 mg/hydrochlorothiazide 25 mg.
Use with Other Antihypertensive Drugs
Tekturna HCT may be administered with other antihypertensive agents. It is not known whether additive effects are present when Tekturna HCT is used with angiotensin-converting enzyme inhibitors or beta blockers. [ See Clinical Studies (14) ] .
Relationship to Meals
Patients should establish a routine pattern for taking Tekturna HCT with regard to meals. High-fat meals decrease absorption substantially [ s ee Clinical Pharmacology (12.3) ] .
Dosing in Specific Populations
The usual regimens of Tekturna HCT may be followed as long as the patient’s creatinine clearance is >30 mL/min. In patients with more severe renal impairment, loop diuretics are preferred to thiazides, so Tekturna HCT is not recommended.
Adjustment of the starting dose is not necessary with hepatic impairment.
Adjustment of the starting dose is not required for elderly patients.
DOSAGE FORMS AND STRENGTHS
- 150 mg/12.5 mg tablets: white, biconvex ovaloid, film-coated tablets imprinted with NVR/LCI
- 150 mg/25 mg tablets: pale yellow, biconvex ovaloid, film-coated tablets imprinted with NVR/CLL
- 300 mg/12.5 mg tablets: violet white, biconvex ovaloid, film-coated tablets imprinted with NVR/CVI
- 300 mg/25 mg tablets: light yellow, biconvex ovaloid, film-coated tablets imprinted with NVR/CVV