TEKAMLO SUMMARY
Tekamlo is a single tablet of aliskiren hemifumarate (an orally active, nonpeptide, potent direct renin inhibitor) and amlodipine besylate (a dihydropyridine calcium channel blocker).
Tekamlo (ALISKIREN/AMLODIPINE) is indicated for the following:
Tekamlo is a combination of aliskiren, a renin inhibitor, and amlodipine, a dihydropyridine calcium channel blocker, indicated for the treatment of hypertension:
- As initial therapy in patients likely to need multiple drugs to achieve their blood pressure goals. (1)
- In patients not adequately controlled with monotherapy.
- As a substitute for its titrated components.
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NEWS HIGHLIGHTSMedia Articles Related to Tekamlo (Aliskiren / Amlodipine)
Small study makes important discovery about idiopathic pulmonary arterial hypertension
Source: Cardiovascular / Cardiology News From Medical News Today [2015.01.19]
A small study being published in Annals of Internal Medicine may reveal an important discovery about idiopathic pulmonary arterial hypertension (IPAH), a rare and deadly disease.
Kidney donation by older people with hypertension may be safe with proper monitoring
Source: Hypertension News From Medical News Today [2014.12.31]
With proper monitoring, kidney donation may be safe for individuals with high blood pressure, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology...
High fitness levels reduce hypertension risk
Source: Hypertension News From Medical News Today [2014.12.18]
Researchers have found that individuals with high levels of physical fitness are less likely to develop high blood pressure in a new study.
Poor semen quality linked to hypertension, other health problems
Source: Fertility News From Medical News Today [2014.12.10]
A study of more than 9,000 men with fertility problems has revealed a correlation between the number of different defects in a man's semen and the likelihood that the man has other health problems.
Picture of Hypertension
Source: MedicineNet Pregnancy Induced Hypertension Specialty [2014.12.09]
Title: Picture of Hypertension
Category: Images
Created: 2/3/2011 1:47:00 PM
Last Editorial Review: 12/9/2014 12:00:00 AM
Published Studies Related to Tekamlo (Aliskiren / Amlodipine)
Effect of aliskiren addition to amlodipine on ankle edema in hypertensive patients: a three-way crossover study. [2011.06]
CONCLUSIONS: Direct renin inhibition by aliskiren partially counteracts the microcirculatory changes responsible for calcium-channel-induced edema formation, possibly through preferential vasodilation of venous capacitance vessels.
Efficacy and safety of aliskiren-based dual and triple combination therapies in US minority patients with stage 2 hypertension. [2011.03]
Minority patients with hypertension generally require combination therapy to reach blood pressure (BP) goals. We examined the BP-lowering efficacy and safety of combination aliskiren/amlodipine therapy in self-identified minority patients in the United States with stage 2 hypertension and the impact of adding hydrochlorothiazide (HCTZ) to this combination...
Differential effects of aliskiren/amlodipine combination and high-dose amlodipine
monotherapy on endothelial function in elderly hypertensive patients. [2014]
amlodipine monotherapy on endothelial function in elderly hypertensive patients... CONCLUSION: Addition of aliskiren improved endothelial function in elderly
Comparative efficacy and safety of combination aliskiren/amlodipine and amlodipine monotherapy in African Americans with stage 2 hypertension and obesity or metabolic syndrome. [2011.11]
The renin-angiotensin system (RAS) is a common link between hypertension and comorbidities of obesity and metabolic syndrome (MetS). We evaluated the antihypertensive efficacy and safety of the combination direct renin inhibitor, aliskiren, with amlodipine versus amlodipine alone in self-identified African Americans with stage 2 hypertension in a subgroup of patients with obesity or MetS participating in the Aliskiren Amlodipine Combination in African AmEricans with Stage 2 HypertenSion (AACESS) trial.
Comparative efficacy and safety of combination aliskiren/amlodipine and amlodipine monotherapy in African Americans with stage 2 hypertension. [2011.08]
Initial multiple drug therapy for hypertension achieves greater and quicker reductions and higher blood pressure (BP) control rates than monotherapy. This 8-week, prospective, multicenter, randomized, double-blind study compared the efficacy and safety of the initial combination of aliskiren/amlodipine with amlodipine monotherapy in African Americans with stage 2 hypertension...
Clinical Trials Related to Tekamlo (Aliskiren / Amlodipine)
Effects of Aliskiren and Amlodipine on the Renin-Angiotensin System (RAS) and Lipid/Carbohydrate Metabolism in Obese Patients With Hypertension [Recruiting]
Part 1 investigated aliskiren, amlodipine and angiotensin II levels in interstitial fluid of
fat and skeletal muscle; aliskiren concentration, angiotensin II levels, and renin activity
and concentration in fat and skeletal muscle tissues; aliskiren and amlodipine
concentrations, angiotensin II levels, and renin activity and concentrations in plasma.
Part 2 investigates the potential for aliskiren to modulate renin-angiotensin-aldosterone
system (RAAS) activity, and lipid/carbohydrate metabolism in adipose and skeletal muscle
tissue in obese patients with hypertension in comparison to amlodipine.
A Randomized Controlled Trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly People [Recruiting]
This study will provide new information regarding the role of aliskiren (with or without
additional therapy with a diuretic or a CCB) in elderly individuals (≥ 65 years) with SBP
130 to 159 mmHg, in preventing major CV events and on global measures of physical, executive
and cognitive function.
Reports of Suspected Tekamlo (Aliskiren / Amlodipine) Side Effects
Diabetes Mellitus (6),
Osteoporosis (6),
Poor Quality Sleep (6),
Blood Uric Acid Increased (6),
Vasodilatation (6),
Breast Cancer (6),
Hypoaesthesia (6),
Alopecia (6),
Hypothyroidism (6),
Oedema Peripheral (3), more >>
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