NEWS HIGHLIGHTS
Published Studies Related to Taztia XT (Diltiazem)
Topical diltiazem hydrochloride and glyceryl trinitrate in the treatment of chronic anal fissure. [2009.10]
Objective: To compare the symptomatic relief, healing and side-effects of topical diltiazem (DTZ) and glyceryl trinitrate in the treatment of chronic anal fissure...
Effect of diltiazem on kidney function during laparoscopic surgery. [2009.08]
BACKGROUND: Pneumoperitoneum is known to be associated with transient impairment in kidney function. This study was designed to investigate the effect of diltiazem on acute kidney injury during positive pneumoperitoneum in patients undergoing laparoscopic surgery... CONCLUSION: Continuous infusion of diltiazem 2 microg/kg/min prevented the decrease in CrCl during pneumoperitoneum without hemodynamic derangement. Although the decrease in CrCl was transient in patients with normal kidney function in this study, diltiazem may be used to prevent further kidney injury in those with elevated CrCl during laparoscopic surgery.
Intravenous diltiazem is superior to intravenous amiodarone or digoxin for achieving ventricular rate control in patients with acute uncomplicated atrial fibrillation. [2009.07]
OBJECTIVES: To compare the clinical efficacy of intravenous diltiazem, digoxin, and amiodarone for acute ventricular rate (VR) control in patients with acute symptomatic atrial fibrillation (AF) necessitating hospitalization... CONCLUSIONS: As compared with digoxin and amiodarone, intravenous diltiazem was safe and effective in achieving VR control to improve symptoms and to reduce hospital stay in patients with acute AF.
Comparison of internal sphincterotomy with topical diltiazem for post-hemorrhoidectomy pain relief: a prospective randomized trial. [2009.01]
AIM: To assess the efficacy of internal sphincterotomy compared with application of topical 2% Diltiazem ointment after hemorrhoidectomy for pain relief. SETTINGS AND DESIGN: Prospective randomized study... CONCLUSIONS: In patients undergoing hemorrhoidectomy, addition of surgical internal sphincterotomy results in lesser pain in the postoperative period as compared to those receiving topical application of Diltiazem.
Influence of grape juice and orange juice on the pharmacokinetics and pharmacodynamics of diltiazem in healthy human male subjects. [2008.10]
CONCLUSIONS: There is no significant influence of grape juice or orange juice on the pharmacokinetics and pharmacodynamics of diltiazem.
Clinical Trials Related to Taztia XT (Diltiazem)
Bioequivalence Study Of Verapamil [Recruiting]
To demonstrate bioequivalence of single doses of two verapamil formulations
An Interaction Study of Ketoconazole/Verapamil Versus AZD1305 [Recruiting]
The purpose is to study whether ketoconazole or verapamil have an effect on how AZD1305 is
handled by the body, i. e the absorption, distribution, metabolism and excretion, when
administered in combination with AZD1305.
Adalat ® XL® vs Diltiazem on Proteinuria and Blood Pressure in Hypertensive Diabetic Patients [Recruiting]
The study consists of a 12 week run-in period when all subjects are stabilized on a single
dose of Avalide (300 mg/12. 5 mg or 300mg/25mg dose) per day. After this 12 week run-in ends,
subjects will be randomly assigned to start the addition of either Adalat XL or Tiazac XC for
18 weeks of treatment. Subjects will have a 1 in 2 chance of receiving the study drug Adalat
XL and a 1 in 2 chance of receiving the drug Tiazac XC. An end of treatment visit will be
done 18 weeks after start of study drug. The expected duration of the study is 30 weeks. The
purpose of this study is to compare the change in proteinuria, through a urine test, while
taking study drug until high blood pressure (BP) is reduced to near normal levels in study
subjects with diabetic nephropathy and hypertension.
Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem [Recruiting]
This is a pilot clinical study to assess whether the administration of diltiazem may be able
to decrease the development or progression of hypertrophic cardiomyopathy (HCM). Diltiazem
is a commonly used medication for the treatment of high blood pressure and studies on
animals with HCM suggest that diltiazem decreases disease development. This study
specifically targets individuals in the "prehypertrophic" phase of HCM-- those with
documented sarcomere gene mutations without echocardiographic or EKG evidence of LVH.
The hypothesis of this study is that starting diltiazem administration early in life (in the
prehypertrophic phase) will decrease the progression of HCM in individuals with sarcomere
gene mutations. This will be assessed by looking at an improvement in the heart's ability to
relax using echocardiography.
Verapamil and Catamenial Epilepsy [Not yet recruiting]
One in 3 epilepsy patients have refractory seizures. This drug resistance is likely related
to the over expression of multidrug resistance proteins (MDR). Progesterone is a known
inhibitor of MDRs and the low level of this hormone during the menstrual cycle may
exacerbate seizures, perhaps explaining catamenial epilepsy; i. e. seizures occurring during
the menstrual cycle. Verapamil suppresses seizures in animal models of epilepsy perhaps by
inhibiting MDRs and thus may help patients with refractory seizures. If the study shows
improved seizure control, the results will help establish the role of MDRs in refractory
epilepsy.
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