Tazorac (Tazarotene Cutaneous) - Summary

TAZORAC SUMMARY

TAZORAC^®(tazarotene) Gel 0.05%
(tazarotene) Gel 0.1%

TAZORAC^® Gel is a translucent, aqueous gel and contains the compound tazarotene, a member of the acetylenic class of retinoids. It is for topical dermatologic use only.

TAZORAC^® (tazarotene) Gel 0.05% and 0.1% are indicated for the topical treatment of patients with stable plaque psoriasis of up to 20% body surface area involvement.

TAZORAC^® (tazarotene) Gel 0.1% is also indicated for the topical treatment of patients with facial acne vulgaris of mild to moderate severity.

The efficacy of TAZORAC^® Gel in the treatment of acne previously treated with other retinoids or resistant to oral antibiotics has not been established.

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NEWS HIGHLIGHTS

Published Studies Related to Tazorac (Tazarotene Cutaneous)

Comparative efficacy and safety results of two topical combination acne regimens. [2009.07]
Combination therapy has become the standard for the management of acne, particularly for moderate-to-severe cases... Both treatment regimens were well-tolerated.

Randomized double-blind trial of prophylactic oral minocycline and topical tazarotene for cetuximab-associated acne-like eruption. [2007.12.01]
PURPOSE: To evaluate the ability of either oral minocycline, topical tazarotene or both, to reduce or prevent cetuximab-related acneiform rash when administered starting on day 1 of cetuximab therapy... CONCLUSION: Prophylaxis with oral minocycline may be useful in decreasing the severity of the acneiform rash during the first month of cetuximab treatment. Topical tazarotene is not recommended for management of cetuximab-related rash.

Tolerability comparison of adapalene gel, 0.3% versus tazarotene cream, 0.05% in subjects with healthy skin. [2007.06]
BACKGROUND: Topical retinoids, including adapalene and tazarotene, are a primary treatment choice for patients with acne. Adapalene is currently marketed in a 0.1% concentration in gel and cream formulation. A new gel containing a higher concentration (0.3%) of adapalene has been developed. In clinical studies, adapalene 0.1% concentration has proven to be better tolerated than other retinoids in skin treatment. However, the tolerability of adapalene gel 0.3% has yet to be compared to other topical retinoids. PURPOSE: The purpose of this study was to compare the local cutaneous tolerability of adapalene gel 0.3% once daily versus tazarotene cream 0.05% once daily... CONCLUSION: Adapalene gel 0.3% is very well-tolerated with good cosmetic acceptability.

Comparison of clinical efficacy of topical tazarotene 0.1% cream with topical clobetasol propionate 0.05% cream in chronic plaque psoriasis: a double-blind, randomized, right-left comparison study. [2007.01]
BACKGROUND: No controlled data is available till date comparing topical tazarotene and clobetasol in Indian psoriatic patients. OBJECTIVE: The aim was to compare the clinical efficacy of 12 weeks of once-daily tazarotene 0.1% cream with that of once-daily clobetasol propionate 0.05% cream in the treatment of patients with chronic plaque psoriasis... CONCLUSION: Topical tazarotene 0.1% cream is less effective than topical clobetasol propionate 0.05% cream in the treatment of plaque psoriasis. It has more effect on induration than on erythema and scaling of psoriatic lesions.

Tazarotene versus tazarotene plus hydroquinone in the treatment of photodamaged facial skin: a multicenter, double-blind, randomized study. [2006.09]
OBJECTIVES: To compare the efficacy and tolerability of tazarotene plus hydroquinone versus tazarotene alone in the treatment of facial photodamage... CONCLUSIONS: The adjunctive use of hydroquinone can enhance the efficacy of tazarotene in reducing dyspigmentation associated with photodamage.

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Clinical Trials Related to Tazorac (Tazarotene Cutaneous)

Differin® Gel x12 Wks vs Tazorac® Cream x12 Wks vs Differin® x6 Wks Switched to Tazorac® x6 Wks for Treatment of Acne [Completed]
To determine the efficacy and safety of 12 weeks of treatment with Differin Gel, 0. 1% compared to 12 weeks of treatment with Tazorac Cream, 0. 1% and compared to 6 weeks treatment with Differin Gel, 0. 1% followed by 6 weeks of treatment with Tazorac Cream

Efficacy and Safety Study of Tazarotene (Tazorac) for the Treatment of Brittle Nails [Completed]
The purpose of this study is to determine whether topical tazarotene (Tazorac), a receptor-selective synthetic retinoid that normalizes epidermal differentiation, ameliorates signs and symptoms of brittle nails.

Comparison of Tazarotene and Minocycline Therapies for Maintenance of Facial Acne Vulgaris [Completed]

Dapsone Gel 5% and Tazarotene Cream 0.1% Versus Tazarotene Cream 0.1% Monotherapy for Facial Acne Vulgaris [Recruiting]
A 12-week evaluation of the safety and efficacy of dapsone gel 5% when used with tazarotene cream 0. 1% compared with tazarotene cream 0. 1% monotherapy in treating moderate to severe facial acne vulgaris

Safety and Efficacy Study of Clindamycin/Benzoyl Peroxide/Tazarotene Cream in Subjects With Acne [Recruiting]
Benzoyl peroxide, clindamycin and tazarotene are known to be effective treatment alternative for acne vulgaris. The purpose of this study is to assess the safety and efficacy of a combination product including these actives for the treatment of acne vulgaris.

You may be suitable to take part in this study because you have acne vulgaris on your face. Acne vulgaris usually affects the face, but it can also affect the skin on the chest, arms, legs, and back.

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PATIENT REVIEWS / RATINGS / COMMENTS

Tazorac review by 42 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		Adult onset acne
Dosage & duration:		To use at night on lesions (dosage frequency: once a day) for the period of Used for 3 months
Other conditions:		Menopause
Other drugs taken:		N/A
		Reported Results
Benefits:		The drug cleared the acne. In addition, it peeled away old skin at the site. I used it over small wrinkles and skin lines (without doctor's knowledge). I was pleased with the results over small skin lines. These dissapeared or diminished. The product does not work over face parenthesis or deep wrinkles. It appeared to me that skin's tone also improved. The skin also developed a healthy shine.
Side effects:		The side effects as reported are skin redness and sun sensitivity. I experienced both. Always use this product with a sun screen or you will burn 10X faster. The product should be used as directed and a little goes a long ways. I used too much at the beggining (I also left on the product during the day) and my skin got really irritated and peeled.
Comments:		The product was to be used at bedtime. To leave on all night and wash in the morning. The treatment was to continue until acne resolved then use as needed.

Tazorac review by 36 year old female patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		Moderate Side Effects
		Treatment Info
Condition / reason:		facial acne
Dosage & duration:		apply nightly (dosage frequency: at breakout) for the period of 3-4 months
Other conditions:		none
Other drugs taken:		Klaron
		Reported Results
Benefits:		Always prescribed together with topical antibiotics such as Klaron. Quite effective in curing acne, but takes months and situation gets worse in the first week to month.
Side effects:		Tazorac can peel the skin severely when used together with other medication. Still moderate peel when applied once every night.
Comments:		I'm an Asian female in my 30s and have been having moderate acne problem for over 20 years. Amoung over-the-counter medication, only benzal peroxide works for me, but I still have break-outs from time to time. My primary care doctor prescribed Tazorac and Klaron for me about 2 years ago and it was very effective in clearing up the acnes in a few months. But even the prescription cannot fully cure the problem and doesn't prevent future break-outs.

Tazorac review by 24 year old female patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		Severe Side Effects
		Treatment Info
Condition / reason:		Acne
Dosage & duration:		Topical (dosage frequency: 3-4 times per week) for the period of 3 months
Other conditions:		Hormonal Imbalances; Lyme Disease
Other drugs taken:		antibiotics
		Reported Results
Benefits:		It exfoliated my skin.
Side effects:		My skin became extremely dry, irritated, red, and would peel.
Comments:		Use once daily, at night. Wash face, use toner and leave to dry (10 minutes). Then apply pea size amount of cream all over face, excluding eye area. Let soak in (15 minutes), then layer with moisturizer. Must wear sunscreen daily.