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Tazorac (Tazarotene Cutaneous) - Summary

 
 



TAZORAC SUMMARY

TAZORAC®(tazarotene) Gel 0.05%
(tazarotene) Gel 0.1%

TAZORAC® Gel is a translucent, aqueous gel and contains the compound tazarotene, a member of the acetylenic class of retinoids. It is for topical dermatologic use only.

TAZORAC® (tazarotene) Gel 0.05% and 0.1% are indicated for the topical treatment of patients with stable plaque psoriasis of up to 20% body surface area involvement.

TAZORAC® (tazarotene) Gel 0.1% is also indicated for the topical treatment of patients with facial acne vulgaris of mild to moderate severity.

The efficacy of TAZORAC® Gel in the treatment of acne previously treated with other retinoids or resistant to oral antibiotics has not been established.


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NEWS HIGHLIGHTS

Published Studies Related to Tazorac (Tazarotene Cutaneous)

Randomized comparison of the safety and efficacy of tazarotene 0.1% cream and adapalene 0.3% gel in the treatment of patients with at least moderate facial acne vulgaris. [2010.05]
This 16-week study evaluated once-daily tazarotene 0.1% cream and adapalene 0.3% gel in patients with moderate-to-severe acne. Patients treated with tazarotene 0.1% cream performed better in many acne efficacy measures (reduction in lesion counts, percentage of patients achieving a 50 percent lesion count reduction, overall disease severity, investigator's global assessment) than did patients treated with adapalene 0.3% gel...

Comparative efficacy and safety results of two topical combination acne regimens. [2009.07]
Combination therapy has become the standard for the management of acne, particularly for moderate-to-severe cases... Both treatment regimens were well-tolerated.

Randomized double-blind trial of prophylactic oral minocycline and topical tazarotene for cetuximab-associated acne-like eruption. [2007.12.01]
PURPOSE: To evaluate the ability of either oral minocycline, topical tazarotene or both, to reduce or prevent cetuximab-related acneiform rash when administered starting on day 1 of cetuximab therapy... CONCLUSION: Prophylaxis with oral minocycline may be useful in decreasing the severity of the acneiform rash during the first month of cetuximab treatment. Topical tazarotene is not recommended for management of cetuximab-related rash.

Tolerability comparison of adapalene gel, 0.3% versus tazarotene cream, 0.05% in subjects with healthy skin. [2007.06]
BACKGROUND: Topical retinoids, including adapalene and tazarotene, are a primary treatment choice for patients with acne. Adapalene is currently marketed in a 0.1% concentration in gel and cream formulation. A new gel containing a higher concentration (0.3%) of adapalene has been developed. In clinical studies, adapalene 0.1% concentration has proven to be better tolerated than other retinoids in skin treatment. However, the tolerability of adapalene gel 0.3% has yet to be compared to other topical retinoids. PURPOSE: The purpose of this study was to compare the local cutaneous tolerability of adapalene gel 0.3% once daily versus tazarotene cream 0.05% once daily... CONCLUSION: Adapalene gel 0.3% is very well-tolerated with good cosmetic acceptability.

Comparison of clinical efficacy of topical tazarotene 0.1% cream with topical clobetasol propionate 0.05% cream in chronic plaque psoriasis: a double-blind, randomized, right-left comparison study. [2007.01]
BACKGROUND: No controlled data is available till date comparing topical tazarotene and clobetasol in Indian psoriatic patients. OBJECTIVE: The aim was to compare the clinical efficacy of 12 weeks of once-daily tazarotene 0.1% cream with that of once-daily clobetasol propionate 0.05% cream in the treatment of patients with chronic plaque psoriasis... CONCLUSION: Topical tazarotene 0.1% cream is less effective than topical clobetasol propionate 0.05% cream in the treatment of plaque psoriasis. It has more effect on induration than on erythema and scaling of psoriatic lesions.

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Clinical Trials Related to Tazorac (Tazarotene Cutaneous)

Differin® Gel x12 Wks vs Tazorac® Cream x12 Wks vs Differin® x6 Wks Switched to Tazorac® x6 Wks for Treatment of Acne [Completed]
To determine the efficacy and safety of 12 weeks of treatment with Differin Gel, 0. 1% compared to 12 weeks of treatment with Tazorac Cream, 0. 1% and compared to 6 weeks treatment with Differin Gel, 0. 1% followed by 6 weeks of treatment with Tazorac Cream

Efficacy and Safety Study of Tazarotene (Tazorac) for the Treatment of Brittle Nails [Completed]
The purpose of this study is to determine whether topical tazarotene (Tazorac), a receptor-selective synthetic retinoid that normalizes epidermal differentiation, ameliorates signs and symptoms of brittle nails.

Comparison of Tazarotene and Minocycline Therapies for Maintenance of Facial Acne Vulgaris [Completed]

Tazarotene 0.1% Cream For the Treatment of Cutaneous T-Cell Lymphoma: A Prospective Study [Recruiting]
This is an open label, prospective study to evaluate therapeutic potential of Tazarotene 0. 1% cream for the treatment of Stage I-IIA CTCL. Patients with Stage I-IIA disease are enrolled into the study. Tazarotene will be used for up to 24 weeks and patients will be followed for up to 12 months.

Acitretin or Tazarotene Gel and Excimer Laser for Treatment of Psoriasis [Recruiting]
The hypothesis of this study is that excimer (308-nm UVB) laser added to either tazarotene 0. 1% gel or acitretin 25 mg daily will lead to improved efficacy of these treatments alone.

The primary objective of this study is to compare the improvement of psoriatic plaques with and without excimer laser (308-nm UVB) treatment, applied in a randomized and blinded fashion, in subjects on acitretin 25 mg or tazarotene gel 0. 1% QD. The primary endpoint will be the comparison between the change in NPF score of plaques treated with excimer laser and those treated with sham treatment.

The secondary objectives are to compare the number of excimer light treatments and time necessary to achieve an average lesion assessment score of 0 to 1 in subjects treated with acitretin 25 mg PO or tazarotene gel 0. 1% QD, and to evaluate adverse events related to combinations of the study treatments.

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Reports of Suspected Tazorac (Tazarotene Cutaneous) Side Effects

Pregnancy (12)Erythema (6)Skin Exfoliation (5)Pruritus (3)Pain (3)Skin Burning Sensation (3)Burning Sensation (3)Drug Ineffective (2)Skin Hyperpigmentation (2)Application Site Erythema (2)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 25 ratings/reviews, Tazorac has an overall score of 7.20. The effectiveness score is 7.44 and the side effect score is 6.64. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Tazorac review by 42 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Adult onset acne
Dosage & duration:   To use at night on lesions (dosage frequency: once a day) for the period of Used for 3 months
Other conditions:   Menopause
Other drugs taken:   N/A
  
Reported Results
Benefits:   The drug cleared the acne. In addition, it peeled away old skin at the site. I used it over small wrinkles and skin lines (without doctor's knowledge). I was pleased with the results over small skin lines. These dissapeared or diminished. The product does not work over face parenthesis or deep wrinkles. It appeared to me that skin's tone also improved. The skin also developed a healthy shine.
Side effects:   The side effects as reported are skin redness and sun sensitivity. I experienced both. Always use this product with a sun screen or you will burn 10X faster. The product should be used as directed and a little goes a long ways. I used too much at the beggining (I also left on the product during the day) and my skin got really irritated and peeled.
Comments:   The product was to be used at bedtime. To leave on all night and wash in the morning. The treatment was to continue until acne resolved then use as needed.

 

Tazorac review by 56 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   wrinkles,uneven skin tone,large pores
Dosage & duration:   0.1% cream (dosage frequency: 1x per day) for the period of 3 months
Other conditions:   none
Other drugs taken:   topical hydroquinone4%
  
Reported Results
Benefits:   There was a noticable smoothing of the skin and lightening of age spots.
Side effects:   Slight peeling of the skin occurred as did some redness and dryness. I added additional moisturizer to alleviate dryness
Comments:   Used tazorac cream 01% in conjunction with Obagi Nu- Derm system. Applied it after mixing a small amount with Obagi Blender with hydroquinone after cleansing skin. Used Obagi Clear and Exfoderm and sunscreen during the daytime.

 

Tazorac review by 36 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Hyperpigmentation, light breakouts, fine lines
Dosage & duration:   pea size spread over face nightly (dosage frequency: nightly) for the period of 6 months
Other conditions:   Rheumatoid Arthritis
Other drugs taken:   Methotrexate
  
Reported Results
Benefits:   There was very minimal difference in lines- no noticable change in the melasma. I beleive I am taking the lowest dose and may have benefitted from switching to the more potent formula. I was cautious to do so as I was advised there may be considerable redness & peeling.
Side effects:   Peeling skin, redness Other than sperficial side effects, I did not notice anything else, nothing too uncomfortable. My skin seemes a little bit drier, which is why it was peeling.. I suppose that is how the pharmaceutical company thinks it will help with the fine lines by peeling off layers of skin
Comments:   Nightly application OVER moisturizer to help correct melasma(Age spots, hyperpigmentation)and fine lines as well as reduce acne breakouts. I tried this for the last 6 months after hearing such great feedback from people who tried it.. I had used Retin A previously and did not see any improvement with that.

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Page last updated: 2010-10-05

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