USE IN PREGNANCY
When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, TARKA should be discontinued as soon as possible. See WARNINGS - Fetal/Neonatal Morbidity and Mortality.
TARKA® (trandolapril/verapamil hydrochloride ER) combines a slow release formulation of a calcium channel blocker, verapamil hydrochloride, and an immediate release formulation of an angiotensin converting enzyme inhibitor, trandolapril.
TARKA is indicated for the treatment of hypertension.
This fixed combination drug is not indicated for the initial therapy of hypertension (DOSAGE and ADMINISTRATION).
In using TARKA, consideration should be given to the fact that an angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that trandolapril does not have similar risk (see WARNINGS: Neutropenia/Agranulocytosis).
Media Articles Related to Tarka (Trandolapril / Verapamil)
Source: MedicineNet Angina Specialty [2013.11.25]
Title: Pulmonary Hypertension
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 11/25/2013 12:00:00 AM
Increased risk of alcohol-related hypertension in individuals who flush after drinking
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2013.11.21]
Excessive drinking is a known risk factor for hypertension. Drinking that results in facial flushing indicates high sensitivity or even intolerance to alcohol. A study of the relationship between drinking and these two conditions has found that drinking-related hypertension has a lower threshold value and higher risk in flushers than in non-flushers.
Some allergy suffers with hypertension may be at increased risk for severe reaction
Source: Allergy News From Medical News Today [2013.11.12]
Oral allergy syndrome sufferers that take high blood pressure medications may experience extreme facial swelling and difficulty breathing the next time they bite into a juicy apple.
In low-income urban neighborhoods the rates of diabetes, hypertension, heart disease and stroke are much higher
Source: Hypertension News From Medical News Today [2013.11.07]
There is more to the cost of living in a food desert than higher prices for the few fruits and vegetables sold nearby, according to a study by an Indiana University-Purdue University Indianapolis researcher and the Marion County Public Health Department.
Further positive Opsumit (macitentan) data in pulmonary arterial hypertension presented at CHEST 2013
Source: Hypertension News From Medical News Today [2013.10.31]
Actelion (SIX: ATLN) has announced that following the recent FDA approval and positive CHMP opinion for macitentan (Opsumit®) in pulmonary arterial hypertension (PAH), further positive data on the efficacy of macitentan from the SERAPHIN study were presented at CHEST 2013 in Chicago, USA (26-31 October 2013).
Published Studies Related to Tarka (Trandolapril / Verapamil)
Global differences in blood pressure control and clinical outcomes in the INternational VErapamil SR-Trandolapril STudy (INVEST). [2005.07]
BACKGROUND: The INternational VErapamil SR-Trandolapril Study (INVEST), a prospective, randomized, antihypertensive trial, found that two different medication regimens produced similar blood pressure (BP) control with equivalent cardiovascular (CV) outcomes (death from any cause, nonfatal myocardial infarction [MI], or nonfatal stroke). HYPOTHESIS: The study was undertaken to investigate whether differences exist by global regions in demographics, treatment, and outcomes in the INVEST trial... CONCLUSIONS: In INVEST, regional differences in medication utilization, BP control, and CV outcomes were identified. These disparities warrant further investigation to define appropriate care for patients with hypertension and stable CAD from an international public health perspective.
The effect of trandolapril and its fixed-dose combination with verapamil on proteinuria in normotensive adults with type 2 diabetes. [2004.07]
CONCLUSIONS: Our results suggest that FDTV is more effective than trandolapril in reducing proteinuria in normotensive, type 2 diabetic patients. This effect on proteinuria is not related with blood pressure reduction.
A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial. [2003.12.03]
CONTEXT: Despite evidence of efficacy of antihypertensive agents in treating hypertensive patients, safety and efficacy of antihypertensive agents for coronary artery disease (CAD) have been discerned only from subgroup analyses in large trials. OBJECTIVE: To compare mortality and morbidity outcomes in patients with hypertension and CAD treated with a calcium antagonist strategy (CAS) or a non-calcium antagonist strategy (NCAS)... CONCLUSION: The verapamil-trandolapril-based strategy was as clinically effective as the atenolol-hydrochlorothiazide-based strategy in hypertensive CAD patients.
The verapamil versus amlodipine in nondiabetic nephropathies treated with trandolapril (VVANNTT) study. [2003.07]
BACKGROUND: We tested whether the combination of verapamil (V) or amlodipine (A) with trandolapril (T) affected proteinuria differently from T alone in patients with nondiabetic nephropathies... CONCLUSION: In patients with nondiabetic proteinuric nephropathies treated with T, the combination of V or A does not significantly increase its antiproteinuric effect.
Antihypertensive therapy with verapamil SR plus trandolapril versus atenolol plus chlorthalidone on glycemic control. [2003.05]
BACKGROUND: There is evidence that diuretics and beta blockers impair glucose tolerance, whereas calcium channel blockers and angiotensin converting enzyme blockers lack this metabolic effect. We compared the effect of a combination therapy with a nondihydropyridine calcium channel blocker plus an angiotensin converting enzyme inhibitor and a beta blocker plus a diuretic on hemoglobin A(1c) (Hb A(1c)) in patients with type 2 diabetes and mild-to- moderate hypertension... CONCLUSIONS: HbA(1c) and other parameters of short- and long-term glycemic control were in a more favorable range after antihypertensive treatment with verapamil SR plus trandolapril as compared with atenolol plus chlorthalidone.
Clinical Trials Related to Tarka (Trandolapril / Verapamil)
Tarka vs. Hyzaar in Patients With Metabolic Syndrome (STAR) [Active, not recruiting]
The primary objective of this study is to determine whether impaired glucose tolerance is
improved to a greater degree by Tarka than Hyzaar in subjects with metabolic syndrome
TarkaŽ vs. LotrelŽ in Hypertensive, Diabetic Subjects With Renal Disease (TANDEM) [Active, not recruiting]
The primary objective of this study is to determine if trandolapril/verapamil (TarkaŽ) is
superior to amlodipine/benazepril (LotrelŽ) in reduction of albuminuria in hypertensive
subjects with Type 2 diabetes mellitus (DM) and diabetic nephropathy
Russian Study of the Efficacy and Safety of Tarka in Patients With Hypertension [Active, not recruiting]
This study will investigate antihypertensive activity and safety profile of Tarka in Russian
hypertension patients by ambulatory blood pressure measurement (ABPM)
INVEST: INternational VErapamil SR Trandolapril STudy [Completed]
Because blood pressure affects the heart, blood vessels, kidneys, and the entire body, it is
important to keep it as normal as possible. There are several different ways to control
blood pressure and to prevent or limit the development of heart disease due to high blood
pressure. The purpose of this study is to compare two treatments to see how well they work
and the difference in their side effects. One treatment includes the use of a calcium
antagonist drug (Isoptin sustained release [SR] or Verapamil SR). The other treatment
excludes the calcium antagonist and may include a non-calcium antagonist drug called a beta
blocker (Tenormin or Atenolol). Both treatments may also include medication called
angiotensin converting enzyme (ACE) inhibitors and water pills. None of the drugs in this
study are experimental, they are all approved by the Food and Drug Administration (FDA).
Verapamil and Catamenial Epilepsy [Not yet recruiting]
One in 3 epilepsy patients have refractory seizures. This drug resistance is likely related
to the over expression of multidrug resistance proteins (MDR). Progesterone is a known
inhibitor of MDRs and the low level of this hormone during the menstrual cycle may
exacerbate seizures, perhaps explaining catamenial epilepsy; i. e. seizures occurring during
the menstrual cycle. Verapamil suppresses seizures in animal models of epilepsy perhaps by
inhibiting MDRs and thus may help patients with refractory seizures. If the study shows
improved seizure control, the results will help establish the role of MDRs in refractory
Reports of Suspected Tarka (Trandolapril / Verapamil) Side Effects
Renal Failure Acute (11),
Renal Tubular Disorder (5),
Drug Interaction (5),
Agitation (4), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 1 ratings/reviews, Tarka has an overall score of 9. The effectiveness score is 10 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
Tarka review by 51 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Mild Side Effects|
|Condition / reason:|| || hypertension|
|Dosage & duration:|| || 240/40 (dosage frequency: once daily) for the period of been taking for couple of years|
|Other conditions:|| || hypothyroidism|
|Other drugs taken:|| || synthyroid|
|Benefits:|| || very effectively reduced my blood pressure to a good level and has amitianed it for the 2+ years I have been taking it.|
|Side effects:|| || My lungs feel heavy at times and that produces a hacking cough. It's not all the time, just occasionally. It hasn't been bothersome enough to ask about changing it to something else yet.|
|Comments:|| || I'm taking one pill that contains two different blood pressure medications.
It has been very effective in controlling my hypertension.|
Page last updated: 2013-11-25