Tapazole (Methimazole) - Indications and Dosage

Indications and Usage

Tapazole is indicated in the medical treatment of hyperthyroidism. Long-term therapy may lead to remission of the disease. Tapazole may be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy. Tapazole is also used when thyroidectomy is contraindicated or not advisable.

Dosage and Administration

Tapazole is administered orally. Tablets are usually given in 3 equal doses at approximately 8-hour intervals.

Adult -The initial daily dosage is 15 mg for mild hyperthyroidism, 30 to 40 mg for moderately severe hyperthyroidism, and 60 mg for severe hyperthyroidism, divided into 3 doses at 8-hour intervals. The maintenance dosage is 5 to 15 mg daily.

Pediatric - Initially, the daily dosage is 0.4 mg/kg of body weight divided into 3 doses and given at 8-hour intervals. The maintenance dosage is approximately 1/2 of the initial dose.

How Supplied

Tapazole Tablets are available in:

The 5-mg tablets are round, white to off-white, scored on one side and the other side debossed with “J94”.

They are available as follows:

Bottles of 100 NDC 60793-104-01

The 10-mg tablets are round, white to off-white, scored on one side and the other side debossed with “J95”.

They are available as follows:

Bottles of 100 NDC 60793-105-01

Store at controlled room temperature, 15° to 30°C (59° to 86°F).

Prescribing Information as of February 2004.

Distributed by: King Pharmaceuticals, Inc. Bristol, TN 37620

Manufactured by: AAI Development Services, An aaiPharma Company, 1726 North 23rd St., Wilmington, NC 28405