Talwin (Pentazocine Lactate) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Cardiovascular. Hypotension, tachycardia, syncope.

Respiratory. Rarely, respiratory depression.

Acute CNS Manifestations. Patients receiving therapeutic doses of pentazocine have experienced hallucinations (usually visual), disorientation, and confusion which have cleared spontaneously within a period of hours. The mechanism of this reaction is not known. Such patients should be closely observed and vital signs checked. If the drug is reinstituted it should be done with caution since these acute CNS manifestations may recur.

Other CNS Effects. Dizziness, lightheadedness, hallucinations, sedation, euphoria, headache, confusion, disorientation; infrequently weakness, disturbed dreams, insomnia, syncope, visual blurring and focusing difficulty, depression; and rarely tremor, irritability, excitement, tinnitus.

Autonomic. Sweating; infrequently flushing; and rarely chills.

Gastrointestinal. Nausea, vomiting, constipation, diarrhea, anorexia, rarely abdominal distress.

Allergic. Edema of the face; dermatitis, including pruritus; flushed skin, including plethora; infrequently rash, and rarely urticaria.

Ophthalmic. Visual blurring and focusing difficulty.

Hematologic. Depression of white blood cells (especially granulocytes), which is usually reversible, moderate transient eosinophilia.

Other. Headache, chills, insomnia, weakness, urinary retention, paresthesia, serious skin reactions, including erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis.

REPORTS OF SUSPECTED TALWIN SIDE EFFECTS / ADVERSE REACTIONS

Possible Talwin side effects / adverse reactions in 53 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-15

Patient: 53 year old male

Reactions: Jaundice, Hepatic Function Abnormal, Pain, Coagulopathy, Headache, Pyrexia, Transaminases Increased, Haemangioma of Liver, Malaise, Bacterial Test Positive, Cough, Decreased Appetite, Back Pain, Chromaturia, Nitrite Urine Present, Encephalopathy, White Blood Cells Urine Positive, Diarrhoea, Drug-Induced Liver Injury, Dysuria

Adverse event resulted in: hospitalization

Suspect drug(s):
Ampyra
    Indication: Multiple Sclerosis

Dalfampridine ER 10mg (Dalfampridine ER) Tablet
    Dosage: bid
    Indication: Multiple Sclerosis
    Start date: 2012-03-05
    End date: 2012-04-12

Talwin
    Indication: Back Pain
    Start date: 2012-05-10

Other drugs received by patient: Nuvigil; SAW Palmetto /00833501/ (Serenoa Repens); Tysabri; Advil /00044201/ (Mefenamic Acid); Effexor; Cyclobenzaprine

Possible Talwin side effects / adverse reactions in 53 year old male

Reported by a physician from United States on 2012-06-27

Patient: 53 year old male

Reactions: Transaminases Increased

Adverse event resulted in: hospitalization

Suspect drug(s):
ALL Other Therapeutic Products
    Indication: Multiple Sclerosis

Blinded Therapy
    Indication: Multiple Sclerosis
    Start date: 2012-03-05
    End date: 2012-04-12

Talwin
    Indication: Back Pain
    Start date: 2012-05-10

Other drugs received by patient: SAW Palmetto; Ibuprofen (Advil); ALL Other Therapeutic Products; Cyclobenzaprine; Immunosuppressive Agents; Effexor

Possible Talwin side effects / adverse reactions in 53 year old male

Reported by a physician from United States on 2012-07-26

Patient: 53 year old male

Reactions: Transaminases Increased

Adverse event resulted in: hospitalization

Suspect drug(s):
ALL Other Therapeutic Products
    Indication: Multiple Sclerosis

Blinded Therapy
    Indication: Multiple Sclerosis
    Start date: 2012-03-05
    End date: 2012-04-12

Talwin
    Indication: Back Pain
    Start date: 2012-05-10

Other drugs received by patient: Advil; Effexor; SAW Palmetto; Immunosuppressive Agents; Cyclobenazprine; ALL Other Therapeutic Products