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Tagamet (Cimetidine Hydrochloride) - Summary

 

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TAGAMET SUMMARY

Tagamet (cimetidine) is a histamine H2-receptor antagonist.

Tagamet (cimetidine) is indicated in:

  1. Short-term treatment of active duodenal ulcer. Most patients heal within 4 weeks and there is rarely reason to use Tagamet at full dosage for longer than 6 to 8 weeks (see Dosage and Administration - Duodenal Ulcer). Concomitant antacids should be given as needed for relief of pain. However, simultaneous administration of Tagamet and antacids is not recommended, since antacids have been reported to interfere with the absorption of Tagamet.
  2. Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of active ulcer. Patients have been maintained on continued treatment with Tagamet 400 mg h.s. for periods of up to 5 years.
  3. Short-term treatment of active benign gastric ulcer. There is no information concerning usefulness of treatment periods of longer than 8 weeks.
  4. Erosive gastroesophageal reflux disease (GERD). Erosive esophagitis diagnosed by endoscopy. Treatment is indicated for 12 weeks for healing of lesions and control of symptoms. The use of Tagamet beyond 12 weeks has not been established (see Dosage and Administration --GERD).
  5. Prevention of upper gastrointestinal bleeding in critically ill patients.
  6. The treatment of pathological hypersecretory conditions (i.e., Zollinger-Ellison Syndrome, systemic mastocytosis, multiple endocrine adenomas).

TAGAMET NEWS HIGHLIGHTS

Published Studies Related to Tagamet (Cimetidine)

Intermittent intravenous pantoprazole and continuous cimetidine infusion: effect on gastric pH control in critically ill patients at risk of developing stress-related mucosal disease. [2008.05]

Prospective randomized trial of natural interferon-alpha versus natural interferon-alpha plus cimetidine in advanced renal cell carcinoma with pulmonary metastasis. [2006.08]

Cimetidine does not prevent lung injury in newborn premature infants. [2006.06]

[Effects of cimetidine on chronotropic response to cardiopulmonary exercise testing] [2006.03]

A comparison of oral omeprazole and intravenous cimetidine in reducing complications of duodenal peptic ulcer. [2006.01.11]

more>>

Clinical Trials Related to Tagamet (Cimetidine)

Performance of Cimetidine-Corrected MDRD Equation in Renal Transplant Patients [Completed]

A Study to Evaluate the Effect of Cimetidine on CD4 Lymphocyte Counts in HIV Infection [Completed]

Biomet Humeral Stem Data Collection [Recruiting]

Oxford Partial Knee Replacement. A Randomized Clinical Trial of Three Implant Types [Not yet recruiting]

A Clinical Investigation of the Comprehensive®, BioModular®, and Bi-Angular® Shoulder Systems [Enrolling by invitation]

more>>

Page last updated: 2008-06-22

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