TAGAMET SUMMARY
Tagamet (cimetidine) is a histamine H2-receptor antagonist.
Tagamet (cimetidine) is indicated in:
- Short-term treatment of active duodenal ulcer. Most patients heal within 4 weeks and there is rarely reason to use
Tagamet
at full dosage for longer than 6 to 8 weeks (see Dosage and Administration - Duodenal Ulcer). Concomitant antacids should be given as needed for relief of pain. However, simultaneous administration of
Tagamet
and antacids is not recommended, since antacids have been reported to interfere with the absorption of
Tagamet.
- Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of active ulcer. Patients have been maintained on continued treatment with
Tagamet
400 mg h.s. for periods of up to 5 years.
- Short-term treatment of active benign gastric ulcer. There is no information concerning usefulness of treatment periods of longer than 8 weeks.
- Erosive gastroesophageal reflux disease (GERD). Erosive esophagitis diagnosed by endoscopy. Treatment is indicated for 12 weeks for healing of lesions and control of symptoms. The use of
Tagamet
beyond 12 weeks has not been established (see Dosage and Administration --GERD).
- Prevention of upper gastrointestinal bleeding in critically ill patients.
- The treatment of pathological hypersecretory conditions (i.e., Zollinger-Ellison Syndrome, systemic mastocytosis, multiple endocrine adenomas).
|
NEWS HIGHLIGHTS
Published Studies Related to Tagamet (Cimetidine)
[Efficacy comparison between cimetidine and zinc sulphate in the treatment of multiple and recalcitrant warts] [2009.01] BACKGROUND: Warts are epithelial proliferations on the skin and mucous membrane caused by various types of HPV. They can decrease spontaneously or increase in number and size according to patient's immune status. Cimetidine and zinc sulphate have important effects on the immune system and are used as immunomodulators in the treatment of various diseases. OBJECTIVE: To compare the efficacy of cimetidine and zinc sulphate in the treatment of multiple and recalcitrant warts... CONCLUSIONS: 10 mg/Kg/day zinc sulphate dose seems to be more effective than cimetidine for the treatment of children and adults with multiple and difficult-to-handle warts. However, the small number of patients did not enable any definitive conclusion.
Intermittent intravenous pantoprazole and continuous cimetidine infusion: effect on gastric pH control in critically ill patients at risk of developing stress-related mucosal disease. [2008.05] BACKGROUND: This study aimed to assess intermittent intravenous (IV) pantoprazole for control of gastric acid and the possible prevention of upper gastrointestinal (UGI) bleeding in intensive care units (ICU) patients... CONCLUSIONS: This pilot study indicates that intermittent IV pantoprazole effectively controls gastric pH and may protect against UGI bleeding in high risk ICU patients without the development of tolerance.
Prospective randomized trial of natural interferon-alpha versus natural interferon-alpha plus cimetidine in advanced renal cell carcinoma with pulmonary metastasis. [2006.08] PURPOSE: In a preliminary non-randomized study, combination therapy with natural (i.e. non-recombinant) interferon-alpha plus cimetidine obtained a high response rate in patients with advanced renal cell carcinoma. We conducted a prospective randomized phase III trial to determine whether combination therapy with natural interferon-alpha plus cimetidine is superior to natural interferon-alpha alone in patients with advanced renal cell carcinoma with pulmonary metastasis... CONCLUSIONS: Combined treatment with natural interferon-alpha plus cimetidine for advanced renal cell carcinoma did not result in a significant improvement in response rates or TTP compared to natural interferon-alpha therapy alone.
Cimetidine does not prevent lung injury in newborn premature infants. [2006.06] Animal studies have shown that induction of cytochrome P450 (CYP) in the lung by oxygen exposure may result in the release of free radical oxidants and arachidonic acid metabolites, which can cause lung injury that is reduced by treatment with cimetidine, a CYP inhibitor... It is possible that cimetidine was not an adequate CYP inhibitor in this context.
[Effects of cimetidine on chronotropic response to cardiopulmonary exercise testing] [2006.03] OBJECTIVE: To test the hypothesis that the administration of cimetidine will modify the chronotropic response to exercise testing through a random clinical trial... CONCLUSION: The administration of cimetidine for 7 days has no significant effect on the chronotropic response to exercise testing.
Clinical Trials Related to Tagamet (Cimetidine)
Performance of Cimetidine-Corrected MDRD Equation in Renal Transplant Patients [Completed]
Among the different creatinine-based GFR predicting equations, the MDRD equation gives the
best prediction in renal transplantation but does not provide the level of accuracy usually
seen in renal patients with native kidneys.
Blocking the tubular secretion of creatinine with an oral administration of cimetidine is
likely to make creatinine a more accurate marker of GFR.
We will test the hypothesis that the accuracy of the MDRD equation will be improved in renal
transplant patients by incorporating into the equation a cimetidine-corrected serum
creatinine value.
A Study to Evaluate the Effect of Cimetidine on CD4 Lymphocyte Counts in HIV Infection [Completed]
To determine the change in CD4 count after 4 and 8 weeks in HIV-infected patients treated
with cimetidine compared to placebo. To observe time-associated trends at weeks 4, 8, 12, and
16 in the change of CD4 counts for patients taking cimetidine for the full 16 weeks. To
establish a safety record for cimetidine use in HIV-positive patients.
Biomet Humeral Stem Data Collection [Recruiting]
Lumbar Spinal Fusion System [Recruiting]
Oxford Partial Knee Replacement. A Randomized Clinical Trial of Three Implant Types [Recruiting]
The purpose of this scientific study is to clarify whether there is a relationship between
the appearance of radiolucent lines in bone-cement interphase of the tibial component of the
different models of the Oxford Uni Knee prosthesis and poor prognosis of these prostheses.
This will be accomplished in a se-ries of three different Oxford Uni Knees.
|