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Synthroid (Levothyroxine Sodium) - Side Effects and Adverse Reactions

 


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ADVERSE REACTIONS

Adverse reactions associated with levothyroxine therapy are primarily those of hyperthyroidism due to therapeutic overdosage (see PRECAUTIONS and OVERDOSAGE). They include the following:

General

fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating;

Central nervous system

headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia;

Musculoskeletal

tremors, muscle weakness;

Cardiovascular

palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest;

Respiratory

dyspnea;

Gastrointestinal

diarrhea, vomiting, abdominal cramps and elevations in liver function tests;

Dermatologic

hair loss, flushing;

Endocrine

decreased bone mineral density;

Reproductive

menstrual irregularities, impaired fertility.

Pseudotumor cerebri and slipped capital femoral epiphysis have been reported in children receiving levothyroxine therapy. Overtreatment may result in craniosynostosis in infants and premature closure of the epiphyses in children with resultant compromised adult height.

Seizures have been reported rarely with the institution of levothyroxine therapy.

Inadequate levothyroxine dosage will produce or fail to ameliorate the signs and symptoms of hypothyroidism.

Hypersensitivity reactions to inactive ingredients have occurred in patients treated with thyroid hormone products. These include urticaria, pruritus, skin rash, flushing, angioedema, various GI symptoms (abdominal pain, nausea, vomiting and diarrhea), fever, arthralgia, serum sickness and wheezing. Hypersensitivity to levothyroxine itself is not known to occur.



REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO SYNTHROID

Below is a sample of reports where side effects / adverse reactions may be related to Synthroid. The information is not vetted and should not be cosidered as verified clinical evidence.

Possible Synthroid side effects / adverse reactions in 48 year old female

Reported by a lawyer from United States on 2007-01-11

Patient: 48 year old female weighing 83.0 kg (182.6 pounds)

Reactions: Weight Decreased, Burning Sensation, Flushing, Hot Flush, Rosacea, Erythema

Suspect drug(s):
Synthroid



Possible Synthroid side effects / adverse reactions in 53 year old female

Reported by a physician from United States on 2007-01-11

Patient: 53 year old female

Reactions: Delusional Disorder, Unspecified Type

Adverse event resulted in: hospitalization

Suspect drug(s):
Adderall 10

Effexor

Synthroid
    Dosage: 0.088mg, 2x/day; bid, oral
    Administration route: Oral



Possible Synthroid side effects / adverse reactions in 47 year old male

Reported by a pharmacist from United States on 2007-01-16

Patient: 47 year old male weighing 143.8 kg (316.3 pounds)

Reactions: Disease Recurrence, Drug Interaction, Anticonvulsant Drug Level Below Therapeutic, Convulsion

Suspect drug(s):
Lexapro
    Dosage: 40 mg qd po
    Administration route: Oral

Lamictal
    Dosage: 100 mg bid
    Indication: Convulsion

Lovenox

Synthroid

Pentoxifylline

Fosamax

Nexium

Gabapentin

Furosemide

Trazodone HCL

Aspirin

Calcium

Folic Acid

Vitamin D



Possible Synthroid side effects / adverse reactions in 47 year old male

Reported by a pharmacist from United States on 2007-01-17

Patient: 47 year old male weighing 144.1 kg (317.0 pounds)

Reactions: Drug Ineffective, Drug Interaction, Anticonvulsant Drug Level Below Therapeutic, Convulsion

Suspect drug(s):
Nexium
    Administration route: Oral

Lamictal
    Administration route: Oral

Lovenox

Folic Acid

Synthroid

Pentoxifylline

Fosamax

Lexapro

Gabapentin

Furosemide

Trazodone HCL

Aspirin

Calcium

Vitamin D



Possible Synthroid side effects / adverse reactions in 47 year old male

Reported by a pharmacist from United States on 2007-02-01

Patient: 47 year old male weighing 144.0 kg (316.8 pounds)

Reactions: Drug Ineffective, Drug Interaction, Convulsion

Suspect drug(s):
Fosamax
    Administration route: Oral

Lamictal
    Administration route: Oral
    Indication: Convulsion

Lovenox

Folic Acid

Synthroid

Pentoxifylline

Lexapro

Nexium

Gabapentin

Furosemide

Trazodone Hydrochloride

Lonazolac Calcium

Aspirin

Vitamin D (Unspecified)

Calcium (Unspecified)



Possible Synthroid side effects / adverse reactions in 69 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2007-02-07

Patient: 69 year old female weighing 113.4 kg (249.5 pounds)

Reactions: Vomiting, Blood Pressure Systolic Increased, Nausea, Sinus Bradycardia, Diarrhoea, Dizziness, Gait Disturbance, Vertigo Positional

Adverse event resulted in: hospitalization

Suspect drug(s):
Rozerem
    Dosage: 8 mg, qhs, per oral
    Administration route: Oral
    Indication: Insomnia
    Start date: 2006-04-20
    End date: 2006-04-25

Paxil
    Dosage: 20 mg, 1 in 1 d, per oral
    Administration route: Oral
    Indication: Affective Disorder

Hyzaar
    Dosage: 1 in 1 d, per oral
    Administration route: Oral
    Indication: Blood Pressure

Synthroid
    Dosage: 125 mcg, 1 in 1 d, per oral
    Administration route: Oral
    Indication: Hypothyroidism

Other drugs received by patient: Aleve; Calcium (Calcium); Fish OIL (Fish Oil); Glucosamine (Glucosamine)



Possible Synthroid side effects / adverse reactions in 3 year old female

Reported by a individual with unspecified qualification from United States on 2007-02-21

Patient: 3 year old female weighing 45.4 kg (99.9 pounds)

Reactions: Asthma, Post Polio Syndrome, Bile Duct Obstruction, Blood Calcium Increased, Thyroxine Free Increased, Haematocrit Decreased, Poliomyelitis, Endocrine Disorder, Unevaluable Event, Blood Creatinine Increased, Blood Pressure Diastolic Decreased, Blood Glucose Increased, Vomiting, Renal Disorder, Pneumonia, Drug Effect Decreased, Blood Urea Increased, Blood Pressure Systolic Increased, Drug Hypersensitivity, Blood Thyroid Stimulating Hormone Decreased, Gastric PH Decreased, Full Blood Count Decreased, Haemoglobin Decreased, Hypothyroidism, Hypertension, Multi-Organ Disorder

Suspect drug(s):
Benadryl
    Dosage: 50mg every 6 hours (50 mg), oral
    Administration route: Oral
    Indication: Hypersensitivity
    Start date: 1928-01-01

Aldactone
    Dosage: 25 mg (25 mg)
    Indication: Hypertension
    Start date: 1998-01-01

Synthroid
    Dosage: 0.3 mg decreased to 0.2 mg (0.3 mg)
    Indication: Hypothyroidism

Theo-DUR
    Dosage: every 12 hours - twice daily (2 in 1 d)
    Indication: Asthma

Prednisone TAB
    Dosage: intravenous
    Indication: Pneumonia

Thyroid TAB
    Dosage: oral
    Administration route: Oral



Possible Synthroid side effects / adverse reactions in 40 year old female

Reported by a consumer/non-health professional from Canada on 2007-02-26

Patient: 40 year old female

Reactions: Blood Pressure Increased, Anal Discomfort, Nausea, Palpitations, Haemorrhoids, Pollakiuria, Cold Sweat

Suspect drug(s):
Synthroid
    Administration route: Oral
    Indication: Hypothyroidism
    Start date: 2007-02-10

Synthroid
    Administration route: Oral

Other drugs received by patient: Vitamin CAP; Progesterone



Possible Synthroid side effects / adverse reactions in 40 year old female

Reported by a consumer/non-health professional from Canada on 2007-03-07

Patient: 40 year old female

Reactions: Blood Pressure Increased, Anal Discomfort, Nausea, Palpitations, Haemorrhoids, Pollakiuria, Cold Sweat

Suspect drug(s):
Synthroid
    Administration route: Oral
    Indication: Hypothyroidism
    Start date: 2007-02-10

Synthroid
    Administration route: Oral

Other drugs received by patient: Vitamin CAP; Progesterone



Possible Synthroid side effects / adverse reactions in 51 year old female

Reported by a consumer/non-health professional from United States on 2007-03-12

Patient: 51 year old female

Reactions: Medication Error, Intercepted Drug Dispensing Error

Suspect drug(s):
Synthroid
    Dosage: tablet bottle 30 tabs
    Indication: Hypothyroidism

Levothyroxine Sodium
    Dosage: tablet



Possible Synthroid side effects / adverse reactions in 40 year old female

Reported by a consumer/non-health professional from Canada on 2007-03-19

Patient: 40 year old female

Reactions: Blood Pressure Increased, Anal Discomfort, Nausea, Palpitations, Haemorrhoids, Pollakiuria, Cold Sweat

Suspect drug(s):
Synthroid
    Administration route: Oral
    Indication: Hypothyroidism
    Start date: 2007-02-10

Synthroid
    Administration route: Oral

Other drugs received by patient: Multi-Vitamins; Progesterone



Possible Synthroid side effects / adverse reactions in 60 year old male

Reported by a consumer/non-health professional from United States on 2007-04-04

Patient: 60 year old male

Reactions: Medication Error, Intercepted Medication Error

Suspect drug(s):
Synthroid



Possible Synthroid side effects / adverse reactions in 25 year old male

Reported by a pharmacist from United States on 2007-05-11

Patient: 25 year old male

Reactions: Dysphagia, Throat Irritation, Urticaria, Throat Tightness

Suspect drug(s):
Synthroid



Possible Synthroid side effects / adverse reactions in 52 year old female

Reported by a individual with unspecified qualification from United States on 2007-05-14

Patient: 52 year old female

Reactions: Dyspnoea, Chest Pain, Liver Function Test Abnormal, Dizziness, Loss of Consciousness, Cardiac Disorder

Suspect drug(s):
Zelnorm
    Dosage: 6 mg, bid
    Indication: Constipation
    Start date: 2006-01-01
    End date: 2007-04-16

Ambien

Synthroid



Possible Synthroid side effects / adverse reactions in 55 year old male

Reported by a physician from United States on 2007-05-18

Patient: 55 year old male weighing 148.0 kg (325.6 pounds)

Reactions: Dyspnoea, Hypersensitivity, Throat Irritation, Wheezing, Loss of Consciousness

Adverse event resulted in: hospitalization

Suspect drug(s):
Synthroid



Possible Synthroid side effects / adverse reactions in 50 year old female

Reported by a consumer/non-health professional from United States on 2007-05-30

Patient: 50 year old female

Reactions: Urticaria Generalised, Injection Site Urticaria, Drug Interaction

Suspect drug(s):
Byetta
    Dosage: 5 mcg;bid;sc
    Indication: Drug USE FOR Unknown Indication
    Start date: 2007-03-12
    End date: 2007-03-28

Synthroid
    Dosage: 37 mg; qd; po
    Administration route: Oral
    Indication: Hypothyroidism

Dicyclomine
    Dosage: 10 mg; tid; po
    Administration route: Oral
    Indication: Abdominal Discomfort
    Start date: 2006-11-01



Possible Synthroid side effects / adverse reactions in 55 year old female

Reported by a consumer/non-health professional from United States on 2007-05-30

Patient: 55 year old female weighing 108.9 kg (239.5 pounds)

Reactions: Weight Decreased, Increased Appetite, Nausea, Faecal Incontinence, Blood Glucose Decreased, Diarrhoea, Catheterisation Cardiac, Vision Blurred, Blood Cholesterol Increased, Energy Increased

Suspect drug(s):
Byetta
    Dosage: see image
    Indication: Diabetes Mellitus non-Insulin-Dependent
    Start date: 2006-01-01
    End date: 2006-01-01

Byetta
    Dosage: see image
    Indication: Diabetes Mellitus non-Insulin-Dependent
    Start date: 2006-01-01
    End date: 2006-12-24

Synthroid
    Indication: Hypothyroidism
    End date: 2006-01-01

Synthroid
    Indication: Hypothyroidism
    Start date: 2006-01-01

Other drugs received by patient: Metformin HCL; Amaryl



Possible Synthroid side effects / adverse reactions in 64 year old female

Reported by a consumer/non-health professional from United States on 2007-05-30

Patient: 64 year old female

Reactions: Weight Decreased, Diarrhoea, Nausea, Hypothyroidism, Injection Site Bruising, Decreased Appetite

Suspect drug(s):
Byetta
    Dosage: 10 mcg; bid; sc, 5 mcg; bid; sc
    Indication: Diabetes Mellitus non-Insulin-Dependent
    Start date: 2007-01-01
    End date: 2007-01-01

Byetta
    Dosage: 10 mcg; bid; sc, 5 mcg; bid; sc
    Indication: Diabetes Mellitus non-Insulin-Dependent
    Start date: 2007-01-01

Synthroid
    Indication: Hypothyroidism

Other drugs received by patient: Diphenoxylate; Hydrochloride Acid; Atropine Sulfate



Possible Synthroid side effects / adverse reactions in 6 month old female

Reported by a physician from Brazil on 2007-06-01

Patient: 6 month old female weighing 1.7 kg (3.8 pounds)

Reactions: Pneumonia, Pyrexia

Adverse event resulted in: hospitalization

Suspect drug(s):
Synthroid
    Administration route: Oral
    Indication: Congenital Hypothyroidism

Synthroid
    Administration route: Oral

Other drugs received by patient: Ferrous Sulfate; Ascorbic Acid; Colecalciferol/vitamin A



Possible Synthroid side effects / adverse reactions in 21 year old female

Reported by a consumer/non-health professional from United States on 2007-06-12

Patient: 21 year old female

Reactions: Weight Increased, Drug Ineffective, Dysphonia, Alopecia, Hypothyroidism, Vertigo, Fall, Convulsion

Suspect drug(s):
Lamictal
    Dosage: 100mg variable dose
    Administration route: Oral
    Indication: Epilepsy

Synthroid
    Administration route: Oral
    Indication: Hypothyroidism



See index of all Synthroid side effect reports >>

Drug label data at the top of this Page last updated: 2008-03-28

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