Synthroid (Levothyroxine Sodium) - Summary

SYNTHROID SUMMARY

SYNTHROID® (levothyroxine sodium tablets, USP) contain synthetic crystalline L-3,3',5,5'-tetraiodothyronine sodium salt [levothyroxine (T₄) sodium]. Synthetic T₄ is identical to that produced in the human thyroid gland.

Levothyroxine sodium is used for the following indications:

Hypothyroidism --As replacement or supplemental therapy in congenital or acquired hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. Specific indications include: primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) hypothyroidism and subclinical hypothyroidism. Primary hypothyroidism may result from functional deficiency, primary atrophy, partial or total congenital absence of the thyroid gland, or from the effects of surgery, radiation, or drugs, with or without the presence of goiter.

Pituitary TSH Suppression --In the treatment or prevention of various types of euthyroid goiters (see WARNINGS and PRECAUTIONS), including thyroid nodules (see WARNINGS and PRECAUTIONS), subacute or chronic lymphocytic thyroiditis (Hashimoto's thyroiditis), multinodular goiter (see WARNINGS and PRECAUTIONS) and, as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.

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SYNTHROID NEWS HIGHLIGHTS

Media Articles Related to Synthroid (Levothyroxine)

levothyroxine sodium, Synthroid, Levoxyl, Levothroid, Unithroid
Source: MedicineNet Hypothyroidism During Pregnancy Specialty [2007.11.16]

Synthroid and Meridia
Source: MedicineNet sibutramine Specialty [2006.11.14]

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Published Studies Related to Synthroid (Levothyroxine)

Lipid profile in different degrees of hypothyroidism and effects of levothyroxine replacement in mild thyroid failure. [2008.04]

Levothyroxine in euthyroid autoimmune thyroiditis and type 1 diabetes: a randomized, controlled trial. [2007.05]

Levothyroxine in euthyroid autoimmune thyroiditis and type 1 diabetes: a randomised, controlled trial. [2007.02.13]

Comparative bioavailability of different formulations of levothyroxine and liothyronine in healthy volunteers. [2006.12]

A bioequivalence study of levothyroxine tablets versus an oral levothyroxine solution in healthy volunteers. [2006.04]

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Clinical Trials Related to Synthroid (Levothyroxine)

Fasting Study of Levothyroxine Sodium Tablets 200 mg to Synthroid Tablets 200 mg [Completed]

Fasting Study of Levothyroxine Sodium Tablets 300 μg to Synthroid® Tablets 300 μg [Completed]

Fasting Study of Levothyroxine Sodium Tablets 300 Mcg to Synthroid® Tablets 300 Mcg [Completed]

Fasting Study of Levothyroxine Sodium Tablets 300 μg to Levothroid® Tablets 300 μg [Completed]

Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation [Completed]

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SYNTHROID PATIENT REVIEWS / RATINGS / COMMENTS

Synthroid review by 46 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		hypothyroid
Dosage & duration:		25 mcg (dosage frequency: 1/day) for the period of for the last 9 mos
Other conditions:		mild hypertension
Other drugs taken:		lexapro, welbutrin, nexium, Benicar
		Reported Results
Benefits:		Increased energy; I happened to be without the drug for one week, and felt absolutely terrible - like I was completely knocked down.
Side effects:		no side effects that i can remember.
Comments:		The doctor ran a series of blood/chemical tests - thyroid, testosterone and DHEA levels. All were somewhat low, the synthroid in particular. We've started out with fairly low levels of each.

Synthroid review by 28 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		hypothyroidism
Dosage & duration:		37 1/2 mcg (dosage frequency: 1 1/2 pills once a day) for the period of so far, about 7 months
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		i have mild hypothyroidism, so i wasn't necessarily aware of what having an underfunctioning was doing to my body. still, i was able to detect changes (for the better) after taking synthroid for a few months. the primary benefit i aw was HIGHLY HIGHLY improved concentration, which has made school/work such a pleasure. i think my metabloism also improved slightly.
Side effects:		none, as far as i could see.
Comments:		take your pill everyday at the same time. i found that morning is best, because you need to wait an hour to eat after taking the pill. i take it right when i wake up, then get ready, and then have breakfast right at the one hour mark.

Synthroid review by 55 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		Thyroid cancer
Dosage & duration:		100 mcg (dosage frequency: once a day) for the period of 8 years and continuing
Other conditions:		None
Other drugs taken:		None
		Reported Results
Benefits:		The treatment benefits of taking Synthroid have everything to do with metabolism regulation. Because I had thyroid cancer the entire thyroid was removed. Since thyroid hormone keeps the body running at optimum speed, it is now essential for me to take medication that will accomplish what my body is no longer capable of doing on its own.
Side effects:		There have been no treatment side effects for me thus far.
Comments:		Treatment consists simply of taking a 100 mcg Synthroid pill each morning. This should be taken on an empty stomach and no food should be taken for one full hour. It is also important not to take any calcium supplement for four hours after taking Synthroid. Calcium interferes with the body's ability to effectively utilize the Synthroid.