Suprane (Desflurane) - Drug Interactions, Contraindications, Overdosage

DRUG INTERACTIONS

Pregnancy Category B

There are no adequate and well-controlled studies in pregnant women. SUPRANE (desflurane, USP) should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Rats exposed to desflurane at 1 MAC-Hour per day from gestation day 15 to lactation day 21, did not show signs of dystocia. Body weight of pups delivered by these dams at birth and during lactation were comparable to that of control pups. No treatment related behavioral changes were reported in these pups during lactation.

OVERDOSAGE

In the event of overdosage, or suspected overdosage, take the following actions: discontinue administration of SUPRANE (desflurane, USP), maintain a patent airway, initiate assisted or controlled ventilation with oxygen, and maintain adequate cardiovascular function.

CONTRAINDICATIONS

SUPRANE (desflurane, USP) should not be used in patients with a known or suspected genetic susceptibility to malignant hyperthermia.

Known sensitivity to SUPRANE (desflurane, USP) or to other halogenated agents.