SUPRANE SUMMARY
Storage
SUPRANE® (desflurane, USP), a nonflammable liquid administered via vaporizer, is a general inhalation anesthetic. It is (±)1,2,2,2-tetrafluoroethyl difluoromethyl ether:
SUPRANE® (desflurane, USP) is indicated as an inhalation agent for induction and/or maintenance of anesthesia for inpatient and outpatient surgery in adults (see PRECAUTIONS).
SUPRANE® (desflurane, USP) is not recommended for induction of anesthesia in pediatric patients because of a high incidence of moderate to severe upper airway adverse events (see WARNINGS). After induction of anesthesia with agents other than SUPRANE®, and tracheal intubation, SUPRANE® is indicated for maintenance of anesthesia in infants and children.
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NEWS HIGHLIGHTSMedia Articles Related to Suprane (Desflurane)
Abdominal Surgery Without General Anesthesia
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2009.11.04]
A recent review in Faculty of 1000 Medicine Reports, a publication in which clinicians highlight advances in medical practice, suggests regional pain relief could be used during abdominal surgery. In this review, Michael Schaefer recommends a new approach that can be performed without the need for general anaesthetics.
Anesthesia, Exertional Heat Deaths May Be Linked
Source: MedicineNet Hyperthermia Specialty [2009.10.26]
Title: Anesthesia, Exertional Heat Deaths May Be Linked
Category: Health News
Created: 10/23/2009 4:10:00 PM
Last Editorial Review: 10/26/2009
Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Source: MedicineNet Hernia Specialty [2009.03.25]
Title: Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Category: Health News
Created: 3/25/2009 2:00:00 AM
Last Editorial Review: 3/25/2009
Need For Emergency Airway Surgery For Hard-to-Intubate Patients Reduced
Source: Respiratory / Asthma News From Medical News Today [2009.11.18]
Be prepared, that old Boy Scout motto, is being applied with great success to operating room patients whose anatomy may make it difficult for physicians to help them breathe during surgery, Johns Hopkins researchers report in a new study. When patients undergo general anesthesia, they stop breathing on their own and anesthesiologists must quickly insert a tube into the airway as a first step in machine-assisted breathing.
New Technique For Injectable Facial Fillers Improves Comfort, Recovery
Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today [2009.10.29]
Less pain during injections for wrinkle-fighting facial fillers. Less swelling afterward. Less time in the office waiting for anesthesia to take effect. These and other benefits of a new injection technique that UT Southwestern Medical Center plastic surgeons are helping pioneer are outlined in the October issue of Plastic and Reconstructive Surgery.
Published Studies Related to Suprane (Desflurane)
Dreaming and electroencephalographic changes during anesthesia maintained with propofol or desflurane. [2009.09]
BACKGROUND: Dream recall is reportedly more common after propofol than after volatile anesthesia, but this may be due to delayed emergence or more amnesia after longer-acting volatiles. The electroencephalographic signs of dreaming during anesthesia and the differences between propofol and desflurane also are unknown. The authors therefore compared dream recall after propofol- or desflurane-maintained anesthesia and analyzed electroencephalographic patterns in dreamers and nondreamers and in propofol and desflurane patients for similarities to rapid eye movement and non-rapid eye movement sleep... CONCLUSIONS: Anesthetic-related dreaming seems to occur just before awakening and is associated with a rapid eye movement-like electroencephalographic pattern.
A comparison between sevoflurane and desflurane anesthesia in patients undergoing craniotomy for supratentorial intracranial surgery. [2009.08]
BACKGROUND: Desflurane in neurosurgery may be beneficial because it facilitates postoperative early neurologic evaluation. However, its use has been debated because of its capacity to promote cerebral vasodilatation. Sevoflurane has been extensively used in neurosurgical patients. In this prospective clinical trial, we compared early postoperative recovery and cognitive function in patients undergoing craniotomy for supratentorial expanding lesions and receiving sevoflurane or desflurane anesthesia... CONCLUSION: Patients who received desflurane had a shorter extubation and recovery time but similar intraoperative and postoperative incidence of complications compared with those who received sevoflurane.
Desflurane versus sevoflurane for maintenance of outpatient anesthesia: the effect on early versus late recovery and perioperative coughing. [2009.08]
BACKGROUND: There is controversy regarding the relative perioperative benefits of desflurane versus sevoflurane when used for maintenance of anesthesia in the ambulatory setting. Although studies have consistently demonstrated a faster emergence with desflurane (versus sevoflurane), the impact of this difference on the later recovery end points has not been definitively established. Furthermore, the effect of desflurane (versus sevoflurane) on the incidence of coughing is also controversial... CONCLUSIONS: Use of desflurane for maintenance of anesthesia was associated with a faster emergence and a higher incidence of coughing. Despite the faster initial recovery with desflurane, no significant differences were found between the two volatile anesthetics in the later recovery period. Both volatile anesthetics should be available for ambulatory anesthesia.
A comparison of the effects of desflurane, sevoflurane and propofol on QT, QTc, and P dispersion on ECG. [2009.07]
The aim of this prospective, randomized, and double-blinded study was to compare the effects of desflurane, sevoflurane, propofol on both atrial and ventricular wall function by measurement of QT dispersion (QTd), corrected QT dispersion (QTcd), and P dispersion (Pd) on electrocardiogram (ECG)... We believe that further investigations are required for using desflurane as safe as sevoflurane and propofol in noncardiac surgery patients who have high cardiac arrhythmia and ischemia risk.
A single dose of esmolol blunts the increase in bispectral index to tracheal intubation during sevoflurane but not desflurane anesthesia. [2009.07]
Activation of the peripheral nerve system by endotracheal intubation is accompanied by an increase in bispectral index (BIS).
Clinical Trials Related to Suprane (Desflurane)
Desflurane Versus Propofol Anesthesia for Off-Pump CABG [Completed]
The purpose of this study is to prove if anesthesia maintained with the inhaled volatile
anesthetic desflurane is superior to the intravenously applied propofol anesthesia in
off-pump coronary artery bypass grafting (OP-CABG) surgery as measured by following
parameters:
1. hemodynamic parameters during and after the operation,
2. pulmonary gas exchange, need for mechanical ventilation and for ICU and intrahospital
stay,
3. release of heart muscle injury markers in response to surgery and intraoperative
ischaemia,
4. inflammatory response to the operation.
We suspect that insufflation anesthesia with desflurane may be superior to intravenous
anesthesia with propofol.
The Effects of DexMed and Desflurane on Carotid Patients [Terminated]
We propose to test whether intraoperative administration of dexmedetomidine will reduce
postoperative neurocognitive dysfunction in patients undergoing carotid endarterectomy.
A Pilot Study to Measure Blood Levels of Desflurane in Children [Recruiting]
In this feasibility study we will collect blood from indwelling arterial catheters in up to
20 patients undergoing non-emergent surgery with desflurane anesthesia at Children's Hospital
of Philadelphia. Desflurane levels will be determined by high pressure liquid chromatography
(HPLC).
Our eventual goal is to quantify fetal levels of desflurane in umbilical cord blood during
fetal surgery. We propose a pilot study to assess the ability of our assay to measure
desflurane in human blood.
Postoperative Pain After Laparoscopic Cholecystectomy After Anesthesia With Isoflurane, Desflurane, Sevoflurane or Propofol [Recruiting]
To the investigators' knowledge, no study has looked at differences in postoperative pain
when comparing maintenance of anesthesia with isoflurane, desflurane, sevoflurane, and
propofol in laparoscopic cholecystectomy. The investigators' hypothesis is that total
intravenous anesthesia with propofol will lead to less postoperative pain in the first 24
hours after laparoscopic cholecystectomy when compared to maintenance of anesthesia with
isoflurane, desflurane or sevoflurane.
PURPOSE
To find out if maintenance of anesthesia with propofol leads to less postoperative pain
after laparoscopic cholecystectomy when compared to maintenance of anesthesia with
isoflurane, desflurane, or sevoflurane.
Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane [Recruiting]
We hypothesise that patients who receive propofol for maintenance of anaesthesia will report
dreaming more often when they emerge from anaesthesia than patients who receive desflurane
for maintenance of anaesthesia.
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