DRUG INTERACTIONS Drug Interactions
PENICILLIN - Since bacteriostatic drugs like tetracycline may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin.
ANTICOAGULANTS - Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.
ANTACIDS AND IRON CONTAINING PRODUCTS - Absorption of tetracycline is impaired by antacids containing aluminum, calcium, or magnesium, and iron containing preparations.
ORAL CONTRACEPTIVES - Concurrent use of tetracycline may render oral contraceptives less effective.
METHOXYFLURANE - The concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.
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REFERENCES
REFERENCES
1. National Committee for Clinical Laboratory Standards, Performance Standards for Antimicrobial Disk Susceptibility Tests –Fourth Edition. Approved Standard NCCLS Document M2-A4, Vol. 10, No. 7 NCCLS, Villanova, PA, April 1990.
2. National Committee for Clinical Laboratory Standards, Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically –Second Edition. Approved Standard NCCLS Document M7-A2, Vol. 10, No. 8 NCCLS, Villanova, PA, April 1990.
Manufactured by:
Bristol-Myers Squibb Company
Princeton, NJ 08543 USA
Manufactured for:
Par Pharmaceutical, Inc.
Spring Valley, NY 10977 USA
1016513A3 03/04
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