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Sumycin (Tetracycline) - Drug Interactions, Contraindications, Overdosage, etc



Drug Interactions

PENICILLIN - Since bacteriostatic drugs like tetracycline may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin.

ANTICOAGULANTS - Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.

ANTACIDS AND IRON CONTAINING PRODUCTS - Absorption of tetracycline is impaired by antacids containing aluminum, calcium, or magnesium, and iron containing preparations.

ORAL CONTRACEPTIVES - Concurrent use of tetracycline may render oral contraceptives less effective.

METHOXYFLURANE - The concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.


In case of overdosage, treat symptomatically and institute supportive measures.


This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines.



1. National Committee for Clinical Laboratory Standards, Performance Standards for Antimicrobial Disk Susceptibility Tests –Fourth Edition. Approved Standard NCCLS Document M2-A4, Vol. 10, No. 7 NCCLS, Villanova, PA, April 1990.

2. National Committee for Clinical Laboratory Standards, Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically –Second Edition. Approved Standard NCCLS Document M7-A2, Vol. 10, No. 8 NCCLS, Villanova, PA, April 1990.

Manufactured by:

Bristol-Myers Squibb Company

Princeton, NJ 08543 USA

Manufactured for:

Par Pharmaceutical, Inc.

Spring Valley, NY 10977 USA

1016513A3 03/04

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