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Sumatriptan (Sumatriptan Succinate) - Summary

 
 



SUMATRIPTAN SUMMARY

Sumatriptan injection, USP contains sumatriptan (as the succinate), a selective 5-HT1B/1D receptor agonist.

Sumatriptan injection is indicated in adults for (1) the acute treatment of migraine, with or without aura, and (2) the acute treatment of cluster headache.

Limitations of Use:

  • Use only if a clear diagnosis of migraine or cluster headache has been established.
  • If a patient has no response to the first migraine attack treated with sumatriptan, reconsider the diagnosis of migraine before sumatriptan is administered to treat any subsequent attacks.
  • Sumatriptan is not indicated for the prevention of migraine attacks.

See all Sumatriptan indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Sumatriptan

Reduced efficacy of sumatriptan in migraine with aura vs without aura. [2015]
migraine with aura compared with migraine without aura... CONCLUSION: This post hoc analysis of pooled data from multiple randomized trials

Sumatriptan iontophoretic transdermal system for the acute treatment of migraine. [2014]
SUMMARY We will describe the pharmacokinetic profile, clinical efficacy and safety data of the sumatriptan iontophoretic transdermal system (Zecuity®, NuPathe Inc., PA, USA), recently approved for the acute treatment of migraine with or without aura in adults, by the US FDA.This sumatriptan transdermal system may be a good choice for migraineurs with severe nausea or vomiting, those with intolerable triptan-related adverse events and/or those not responding optimally to oral medications.

Sumatriptan plus naproxen for acute migraine attacks in adults. [2013]
CONCLUSIONS: Combination treatment was effective in the acute treatment

A sumatriptan iontophoretic transdermal system for the acute treatment of migraine. [2012]
treatment of migraine... CONCLUSIONS: The sumatriptan iontophoretic transdermal system is effective and

Sumatriptan (subcutaneous route of administration) for acute migraine attacks in adults. [2012]
CONCLUSIONS: Subcutaneous sumatriptan is effective as an abortive

more studies >>

Clinical Trials Related to Sumatriptan

A Study to Determine the Effect of Sumatriptan and Naproxen Sodium Combination Tablet, Sumatriptan Tablet, and Naproxen Sodium Tablet on Blood Pressure When Treating Migraine Headaches That Occur During a 6-month Period [Completed]
The purpose of this study is to test the effect on blood pressure of sumatriptan and naproxen sodium combination tablets, tablets containing only sumatriptan, and tablets containing only naproxen sodium when these drugs are taken to treat migraine headaches that occur during a 6-month period.

Bioavailability Study to Compare OPTINOSE SUMATRIPTAN With IMITREX� in Healthy Subjects [Completed]
The purpose of this study is:

- To compare the single-dose pharmacokinetics (PK) of intranasal administration of 20 mg

OPTINOSE SUMATRIPTAN with 20 mg IMITREX (sumatriptan) Nasal Spray, 100 mg IMITREX (sumatriptan) Oral Tablet, and 6 mg IMITREX (sumatriptan) Subcutaneous Injection, in healthy subjects.

- To estimate the relative bioavailability of single-dose intranasal administration of 20

mg OPTINOSE SUMATRIPTAN, 20 mg IMITREX (sumatriptan) Nasal Spray, and 100 mg IMITREX (sumatriptan) Oral Tablet compared to a single-dose of 6 mg IMITREX® (sumatriptan) Subcutaneous Injection, in healthy subjects.

The Effect of Sumatriptan and Placebo on Cilostazol Induced Headache [Recruiting]
To develop a pragmatic migraine model the investigators will induce headache in healthy volunteers and in patients with migraine without aura with a phosphodiesterase inhibitor (cilostazol). If the headache responds to sumatriptan, the model can be used to test new drug candidates.

The Effect of Sumatriptan and Placebo on Isosorbide-5-mononitrate Induced Headache [Recruiting]
To develop a pragmatic migraine model the investigators will induce headache in healthy volunteers and in patients with migraine without aura with a long lasting Nitrogen Oxide (NO) donor. If the headache responds to sumatriptan, the model can be used to test new drug candidates.

Sumatriptan and Naratriptan Pregnancy Registry [Completed]
Anti-migraine drugs, including triptans, are not indicated for use in pregnancy. However, the peak prevalence of migraine is in women of childbearing age. This, coupled with the sporadic nature of migraine attacks and high rates of unplanned pregnancies, makes unintentional exposure to anti-migraine medications during pregnancy likely. Prior to an anti-migraine medication being marketed there are few data available on drug safety in pregnancy: data from animal models may not translate directly to humans and pregnant women are routinely excluded from clinical trials. The Sumatriptan Pregnancy Registry was established by GlaxoSmithKline (GSK) in 1996 to monitor the safety of sumatriptan during pregnancy. It was combined with the Naratriptan Pregnancy Registry in 2001 and data collection on the sumatriptan-naproxen combination (Treximet) began in 2008.

more trials >>

Reports of Suspected Sumatriptan Side Effects

Drug Ineffective (18)Product Quality Issue (13)Maternal Drugs Affecting Foetus (6)Chest Discomfort (6)Apnoea (5)Nausea (5)Bradycardia (5)Product Substitution Issue (4)Hypersensitivity (4)Foetal Exposure During Pregnancy (4)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 4 ratings/reviews, Sumatriptan has an overall score of 9.50. The effectiveness score is 10 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Sumatriptan review by 43 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   maigrains
Dosage & duration:   1 (dosage frequency: once a month) for the period of one week ago
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   ceasation of maigrain. The drug provides relive within half an hour of having been administered and prevents further symptomps
Side effects:   there are no aparent side effects from the use of this drug
Comments:   1 pill to be taken with onset of attack. If the attack has already started and the treatment cannot be reached within the first 5 hours of the attack, a further dose of the drug may be required

 

Sumatriptan review by 49 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   migraine
Dosage & duration:   50 mg taken once a week for the period of one to four doses
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   The drug rapidly gets rid of migraine.
Side effects:   The drug causes slight dizziness and tightness around my temples. Sometimes I also feel slightly nauseated after taking it, but perhaps I should blame the headache and not the medication.
Comments:   I take one dose at onset of headache. I repeat doses of the drug at one hour intervals if headache gets better but then worsens again.

 

Sumatriptan review by 49 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   migraine
Dosage & duration:   50 mg taken once a week for the period of one to four doses
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   The drug rapidly gets rid of migraine.
Side effects:   The drug causes slight dizziness and tightness around my temples. Sometimes I also feel slightly nauseated after taking it, but perhaps I should blame the headache and not the medication.
Comments:   I take one dose at onset of headache. I repeat doses of the drug at one hour intervals if headache gets better but then worsens again.

See all Sumatriptan reviews / ratings >>

Page last updated: 2015-08-10

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