SULFAMYLON SUMMARY
SULFAMYLON®
(mafenide acetate, USP)
FOR 5% TOPICAL SOLUTION
Mafenide acetate, USP is a synthetic antimicrobial agent designated chemically as α-amino- p -toluenesulfonamide monoacetate.
SULFAMYLON® For 5% Topical Solution is provided in packets containing 50 g of sterile mafenide acetate to be reconstituted in 1000 mL of Sterile Water for Irrigation, USP or 0.9% Sodium Chloride Irrigation, USP. After mixing, the solution contains 5% w/v of mafenide acetate.
SULFAMYLON® For 5% Topical Solution is indicated for use as an adjunctive topical antimicrobial agent to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.
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NEWS HIGHLIGHTSMedia Articles Related to Sulfamylon (Mafenide Topical)
PuriCore Announces Promising Clinical Results For Vashe(R) Wound Therapy In Post-Operative Care Of Skin Grafts On Burns
Source: Dermatology News From Medical News Today [2009.11.12]
PuriCore (LSE:PURI), the life sciences company focused on developing and commercializing proprietary solutions that safely, effectively, and naturally kill infectious pathogens, announced results of a randomized clinical trial showing the potential effectiveness of its Vashe Wound Therapy in the post-operative care of split-thickness skin grafts for burn injuries.
Burns (First Aid)
Source: MedicineNet Hyperkalemia Specialty [2008.10.28]
Title: Burns (First Aid)
Category: Diseases and Conditions
Created: 12/31/1997
Last Editorial Review: 10/28/2008
TAU Develops Dissolving Dressing For Wounds Packed With Infection-Fighting Antibiotics
Source: Biology / Biochemistry News From Medical News Today [2009.11.18]
Despite advances in treatment regimens and the best efforts of nurses and doctors, about 70% of all people with severe burns die from related infections. But a revolutionary new wound dressing developed at Tel Aviv University could cut that number dramatically. Prof.
Published Studies Related to Sulfamylon (Mafenide Topical)
Allergic contact dermatitis to mafenide acetate: a case series and review of the literature. [2007.08]
Burn patients with extensive involvement of body surface area (BSA >30%) represent a challenge in wound treatment. Multiple topical agents may be used for cleansing, barrier protection, and antimicrobial control leading to complications of contact and/or irritant dermatitis, which may further complicate re-epithelization and eventual wound healing...
Topical Sulfamylon cream inhibits DNA and protein synthesis in the skin donor site wound. [2006.05]
BACKGROUND: Whereas Sulfamylon is effective in treatment of burn wound infection, controversy exists regarding its effect on the healing process... CONCLUSIONS: Topical Sulfamylon cream application inhibited DNA and protein synthesis in the wound, which would be expected to retard the healing process.
Mafenide acetate allergy presenting as recurrent chondritis. [2002.02]
Acute chondritis has a strong predilection for recurrence. Mafenide acetate has been implicated in causing reactions that mimic this condition; however, these hypersensitivity reactions lack fever, fluctuance, and pain... Therefore, auricular edema and erythema, without fever, fluctuance, and pain, must be recognized by surgeons as a possible mafenide acetate allergy and must be considered in the differential diagnosis for patients who present with recurrent acute suppurative chondritis.
Off-label drug use in WOC nursing: issues related to use of mafenide acetate to treat infected chronic wounds. [2001.09]
It is not unusual for practitioners to prescribe off-label drugs for their patients--that is, drugs that have not yet been approved by the Food and Drug Administration to treat the patient's particular condition... This article presents the issues related to off-label use of mafenide acetate (Sulfamylon) and possible implications for patients with chronic infected wounds.
Topical mafenide hydrochloride aqueous spray in initial management of massive contaminated wounds with devitalized tissue. [2001.07]
Since at least WWII, some open, contaminated wounds involving massive soft tissue injury and vascular damage have resulted in "irreversible shock," despite prompt rescue, hemorrhage control, and blood and fluid replacement, without signs of clinical infection.Mafenide hydrochloride solution spray has been used successfully in treatment of patients with severe by contaminated wounds and deep burns, and its use in initial care should be revisited.
Clinical Trials Related to Sulfamylon (Mafenide Topical)
Prospective Evaluation of the Effects of Topical Therapy With Sulfamylon® For 5% Topical Solution on Autograft Healing in Subjects With Thermal Injuries Requiring Meshed Autografts: A Comparison to a Historical Control Group [Recruiting]
The primary objective is to compare the effectiveness of treatment with Sulfamylon® solution
as the initial topical moist dressing over meshed autografts following the initial graft
procedure on preventing graft loss in a prospective cohort of subjects versus a historical
control group in a non-inferiority trial.
Study of the Treatment of Burn Wounds With Various Antimicrobial Topical Soaks [Recruiting]
Determine effectiveness of various antimicrobial solutions on burn wounds (infections, wound
healing, length of hospital stay).
Vashe Wound Therapy Study [Recruiting]
This study will evaluate the efficacy, safety, and tolerability of topical Vashe™ Wound
Therapy applied to gauze dressing every 6 hours or as necessary to keep dressing moist
versus 5% Mafenide Acetate applied to gauze dressing every 6 hours or as necessary to keep
dressing moist for a total treatment duration of 5 days.
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