(mafenide acetate, USP)
FOR 5% TOPICAL SOLUTION
Mafenide acetate, USP is a synthetic antimicrobial agent designated chemically as α-amino- p -toluenesulfonamide monoacetate.
SULFAMYLON® For 5% Topical Solution is provided in packets containing 50 g of sterile mafenide acetate to be reconstituted in 1000 mL of Sterile Water for Irrigation, USP or 0.9% Sodium Chloride Irrigation, USP. After mixing, the solution contains 5% w/v of mafenide acetate.
SULFAMYLON® For 5% Topical Solution is indicated for use as an adjunctive topical antimicrobial agent to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.
Media Articles Related to Sulfamylon (Mafenide Topical)
Space Heater Safety Tips Can Help Prevent Burns, Fires
Source: MedicineNet Burns Specialty [2013.03.11]
Title: Space Heater Safety Tips Can Help Prevent Burns, Fires
Category: Health News
Created: 3/8/2013 4:35:00 PM
Last Editorial Review: 3/11/2013 12:00:00 AM
Health Tip: Reduce Your Risk of Hot Water Burns
Source: MedicineNet Burns Specialty [2012.11.29]
Title: Health Tip: Reduce Your Risk of Hot Water Burns
Category: Health News
Created: 11/29/2012 8:35:00 AM
Last Editorial Review: 11/29/2012 12:00:00 AM
Topical Products for Muscle, Joint Pain May Cause Burns: FDA
Source: MedicineNet Burns Specialty [2012.09.14]
Title: Topical Products for Muscle, Joint Pain May Cause Burns: FDA
Category: Health News
Created: 9/14/2012 10:05:00 AM
Last Editorial Review: 9/14/2012 12:00:00 AM
Burns (First Aid)
Source: MedicineNet Hyperkalemia Specialty [2008.10.28]
Title: Burns (First Aid)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 10/28/2008 12:00:00 AM
Burn Risk Seen with Topical Pain Relievers
Source: MedPage Today Product Alert [2012.09.13]
WASHINGTON -- The FDA warned Thursday of the risks of rare but serious chemical burns with certain over-the-counter topical pain relievers, including Bengay, Capzasin, Flexall, Icy Hot, and Mentholatum.
Published Studies Related to Sulfamylon (Mafenide Topical)
Systemic absorption of amphotericin B with topical 5% mafenide acetate/amphotericin B solution for grafted burn wounds: is it clinically relevant? [2010.02]
OBJECTIVE: To determine if patients receiving topical amphotericin B in combination with 5% mafenide acetate solution will acquire systemically detectable levels of amphotericin B... CONCLUSIONS: We conclude that 5% mafenide acetate/amphotericin B (2 mcg/ml) solution, applied to excised and grafted burn wounds, does not produce clinically relevant serum levels of amphotericin B. Based on our observations, this topical regimen is safe. Copyright (c) 2009 Elsevier Ltd and ISBI. All rights reserved.
Allergic contact dermatitis to mafenide acetate: a case series and review of the literature. [2007.08]
Burn patients with extensive involvement of body surface area (BSA >30%) represent a challenge in wound treatment. Multiple topical agents may be used for cleansing, barrier protection, and antimicrobial control leading to complications of contact and/or irritant dermatitis, which may further complicate re-epithelization and eventual wound healing...
Topical Sulfamylon cream inhibits DNA and protein synthesis in the skin donor site wound. [2006.05]
BACKGROUND: Whereas Sulfamylon is effective in treatment of burn wound infection, controversy exists regarding its effect on the healing process... CONCLUSIONS: Topical Sulfamylon cream application inhibited DNA and protein synthesis in the wound, which would be expected to retard the healing process.
Mafenide acetate allergy presenting as recurrent chondritis. [2002.02]
Acute chondritis has a strong predilection for recurrence. Mafenide acetate has been implicated in causing reactions that mimic this condition; however, these hypersensitivity reactions lack fever, fluctuance, and pain... Therefore, auricular edema and erythema, without fever, fluctuance, and pain, must be recognized by surgeons as a possible mafenide acetate allergy and must be considered in the differential diagnosis for patients who present with recurrent acute suppurative chondritis.
Off-label drug use in WOC nursing: issues related to use of mafenide acetate to treat infected chronic wounds. [2001.09]
It is not unusual for practitioners to prescribe off-label drugs for their patients--that is, drugs that have not yet been approved by the Food and Drug Administration to treat the patient's particular condition... This article presents the issues related to off-label use of mafenide acetate (Sulfamylon) and possible implications for patients with chronic infected wounds.
Clinical Trials Related to Sulfamylon (Mafenide Topical)
Prospective Evaluation of the Effects of Topical Therapy With SulfamylonÃ¯Â¿Â½ For 5% Topical Solution on Autograft Healing in Subjects With Thermal Injuries Requiring Meshed Autografts: A Comparison to a Historical Control Group [Recruiting]
The primary objective is to compare the effectiveness of treatment with SulfamylonÂ® solution
as the initial topical moist dressing over meshed autografts following the initial graft
procedure on preventing graft loss in a prospective cohort of subjects versus a historical
control group in a non-inferiority trial.
Study of the Treatment of Burn Wounds With Various Antimicrobial Topical Soaks [Recruiting]
Determine effectiveness of various antimicrobial solutions on burn wounds (infections, wound
healing, length of hospital stay).
Vashe Wound Therapy Study [Recruiting]
This study will evaluate the efficacy, safety, and tolerability of topical Vasheâ„¢ Wound
Therapy applied to gauze dressing every 6 hours or as necessary to keep dressing moist
versus 5% Mafenide Acetate applied to gauze dressing every 6 hours or as necessary to keep
dressing moist for a total treatment duration of 5 days.
Study of Low Adherent Dressing Versus the Standard of Care for the Management of Skin Grafts Over Thermal Burns [Recruiting]
The purpose of this study is to evaluate the P6 Low Adherent Study Dressing relative to the
Standard of Care (SOC, Mafenide Acetate 5% Solution) for the management of skin grafts in
burn wounds resulting from thermal burn injuries.