ADVERSE REACTIONS
The most common adverse effects are gastrointestinal disturbances (nausea, vomiting, anorexia) and allergic skin reactions (such as rash and urticaria). FATALITIES ASSOCIATED WITH THE ADMINISTRATION OF SULFONAMIDES, ALTHOUGH RARE, HAVE OCCURRED DUE TO SEVERE REACTIONS, INCLUDING STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, FULMINANT HEPATIC NECROSIS, AGRANULOCYTOSIS, APLASTIC ANEMIA AND OTHER BLOOD DYSCRASIAS (SEE WARNINGS SECTION).
Hematologic: Agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, neutropenia, hemolytic anemia, megaloblastic anemia, hypoprothrombinemia, methemoglobinemia, eosinophilia.
Allergic Reactions: Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylaxis, allergic myocarditis, erythema multiforme, exfoliative dermatitis, angioedema, drug fever, chills, Henoch-Schoenlein purpura, serum sickness-like syndrome, generalized allergic reactions, generalized skin eruptions, photosensitivity, conjunctival and scleral injection, pruritus, urticaria and rash. In addition, periarteritis nodosa and systemic lupus erythematosus have been reported.
Gastrointestinal: Hepatitis (including cholestatic jaundice and hepatic necrosis), elevation of serum transaminase and bilirubin, pseudomembranous enterocolitis, pancreatitis, stomatitis, glossitis, nausea, emesis, abdominal pain, diarrhea, anorexia.
Genitourinary: Renal failure, interstitial nephritis, BUN and serum creatinine elevation, toxic nephrosis with oliguria and anuria, crystalluria and nephrotoxicity in association with cyclosporine.
Metabolic and Nutritional: Hyperkalemia (see PRECAUTIONS: Use in the Treatment of and Prophylaxis for Pneumocystis Carinii Pneumonia in Patients with Acquired Immunodeficiency Syndrome (AIDS).
Neurologic: Aseptic meningitis, convulsions, peripheral neuritis, ataxia, vertigo, tinnitus, headache.
Psychiatric: Hallucinations, depression, apathy, nervousness.
Endocrine: The sulfonamides bear certain chemical similarities to some goitrogens, diuretics (acetazolamide and the thiazides) and oral hypoglycemic agents. Cross-sensitivity may exist with these agents. Diuresis and hypoglycemia have occurred rarely in patients receiving sulfonamides.
Musculoskeletal: Arthralgia and myalgia. Isolated cases of rhabdomyolysis have been reported with sulfamethoxazole and trimethoprim, mainly in AIDS patients.
Respiratory: Cough, shortness of breath, pulmonary infiltrates (see WARNINGS).
Miscellaneous: Weakness, fatigue, insomnia.
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REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO SULFAMETHOXAZOLE AND TRIMETHOPRIM
Below is a sample of reports where side effects / adverse reactions may be related to Sulfamethoxazole and Trimethoprim. The information is not vetted and should not be cosidered as verified clinical evidence.
Possible Sulfamethoxazole and Trimethoprim side effects / adverse reactions in 49 year old male
Reported by a individual with unspecified qualification from United States on 2007-01-05
Patient: 49 year old male weighing 75.4 kg (165.9 pounds)
Reactions: Hyperkalaemia, Blood Creatinine Increased
Adverse event resulted in: hospitalization
Suspect drug(s):
Sulfamethoxazole and Trimethoprim
Other drugs received by patient: Amoxicillin + Clavulanate Potassium; Cyclosporine; Ganciclovir; Metoprolol Succinate; Esomeprazole Magnesium; Amlodipine
Possible Sulfamethoxazole and Trimethoprim side effects / adverse reactions in 17 year old male
Reported by a individual with unspecified qualification from United States on 2007-01-17
Patient: 17 year old male weighing 74.3 kg (163.5 pounds)
Reactions: RED Cell Distribution Width Increased, Neutrophil Count Increased, Drug Ineffective, Pain in Extremity, Oedema Peripheral, Iron Deficiency, Platelet Count Increased, Deep Vein Thrombosis
Adverse event resulted in: hospitalization
Suspect drug(s):
Sulfamethoxazole and Trimethoprim
Dosage: 1 tablet, twice daily, oral
Administration route: Oral
Indication: Acne
Start date: 2006-09-01
End date: 2006-11-30
Doxycycline
Dosage: 100 mg, twice daily, oral
Administration route: Oral
Indication: Acne
Start date: 2006-11-30
End date: 2006-12-08
Possible Sulfamethoxazole and Trimethoprim side effects / adverse reactions in 40 year old male
Reported by a individual with unspecified qualification on 2007-01-22
Patient: 40 year old male
Reactions: Death
Adverse event resulted in: death
Suspect drug(s):
Nevirapine
Administration route: Oral
Indication: HIV Infection
Lamivudine
Administration route: Oral
Indication: HIV Infection
Stavudine
Administration route: Oral
Indication: HIV Infection
Ceftrioxone
Dosage: 1 - 2 g
Itraconazole
Administration route: Oral
Sulfamethoxazole and Trimethoprim
Dosage: 960 mg tmp, 4800 mg smx
Indication: Pneumocystis Jiroveci Pneumonia
Erythromycin
Administration route: Oral
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