NEWS HIGHLIGHTSMedia Articles Related to Sufenta (Sufentanil)
Abdominal Surgery Without General Anesthesia
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2009.11.04]
A recent review in Faculty of 1000 Medicine Reports, a publication in which clinicians highlight advances in medical practice, suggests regional pain relief could be used during abdominal surgery. In this review, Michael Schaefer recommends a new approach that can be performed without the need for general anaesthetics.
Anesthesia, Exertional Heat Deaths May Be Linked
Source: MedicineNet Hyperthermia Specialty [2009.10.26]
Title: Anesthesia, Exertional Heat Deaths May Be Linked
Category: Health News
Created: 10/23/2009 4:10:00 PM
Last Editorial Review: 10/26/2009
Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Source: MedicineNet Hernia Specialty [2009.03.25]
Title: Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Category: Health News
Created: 3/25/2009 2:00:00 AM
Last Editorial Review: 3/25/2009
Need For Emergency Airway Surgery For Hard-to-Intubate Patients Reduced
Source: Respiratory / Asthma News From Medical News Today [2009.11.18]
Be prepared, that old Boy Scout motto, is being applied with great success to operating room patients whose anatomy may make it difficult for physicians to help them breathe during surgery, Johns Hopkins researchers report in a new study. When patients undergo general anesthesia, they stop breathing on their own and anesthesiologists must quickly insert a tube into the airway as a first step in machine-assisted breathing.
New Technique For Injectable Facial Fillers Improves Comfort, Recovery
Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today [2009.10.29]
Less pain during injections for wrinkle-fighting facial fillers. Less swelling afterward. Less time in the office waiting for anesthesia to take effect. These and other benefits of a new injection technique that UT Southwestern Medical Center plastic surgeons are helping pioneer are outlined in the October issue of Plastic and Reconstructive Surgery.
Published Studies Related to Sufenta (Sufentanil)
Safety and effectiveness of coadministration of intrathecal sufentanil and morphine in hyperbaric bupivacaine-based spinal anesthesia for cesarean section. [2009.07]
Subarachnoid block is a widely used technique for cesarean section... In conclusion, coadministration of sufentanil and morphine into the subarachnoid space was effective and provided longer pain relief than intrathecal sufentanil plus a single injection of subcutaneous morphine, despite a higher incidence of side effects such as nausea and vomiting.
Minimum local analgesic concentrations of ropivacaine and levobupivacaine with sufentanil for epidural analgesia in labour. [2009.07]
BACKGROUND: Sufentanil is often added to ropivacaine and levobupivacaine to provide epidural analgesia in labour. The aim of this study was to compare the analgesic potencies of epidural ropivacaine and levobupivacaine in combination with sufentanil 0.5 microg/mL, using the minimum local analgesic concentration (MLAC) model with up-down sequential allocation... CONCLUSION: When sufentanil 0.5 microg/mL was added to either ropivacaine or levobupivacaine for labour analgesia, no significant difference in analgesic potency was observed.
Epidural block for cesarean section: a comparative study between 0.5% racemic Bupivacaine (S50-R50) and 0.5% enantiomeric excess Bupivacaine (S75-R25) associated with Sufentanil. [2009.05]
BACKGROUND AND OBJECTIVES: Epidural 0.5% racemic bupivacaine associated with opioids is a technique used in cesarean sections; however, its toxicity has been questioned. 50% Enantiomeric excess bupivacaine has lower cardio- and neurotoxicity. The efficacy of epidural 0.5% racemic bupivacaine and 0.5% enantiomeric excess bupivacaine associated with sufentanil in parturients undergoing cesarean sections was evaluated... CONCLUSIONS: Epidural racemic bupivacaine and 50% enantiomeric excess bupivacaine provided adequate anesthesia for cesarean sections. 50% Enantiomeric excess bupivacaine is a promising alternative for this procedure, since it has faster regression of the motor blockade, which is desirable in obstetric patients.
Optimal dose of sufentanil in children for intubation after sevoflurane induction without neuromuscular block. [2009.05]
BACKGROUND: We studied 63 ASA I children (age 2-8 yr) to determine the sufentanil dose needed to facilitate intubation under excellent conditions after inhalation induction with various end-tidal concentrations of sevoflurane without neuromuscular block... CONCLUSIONS: Excellent intubation conditions could be obtained in children after inhalation induction with low sevoflurane concentrations and adjuvant sufentanil.
Comparison of fentanyl and sufentanil as adjuncts to bupivacaine for labor epidural analgesia. [2009.03]
STUDY OBJECTIVE: To compare the clinical efficacy of theoretically equipotent doses of fentanyl and sufentanil, each in combination with bupivacaine, for patient-controlled epidural analgesia (PCEA) for labor... CONCLUSIONS: At the assumed equipotent sufentanil to fentanyl ratio of 6:1, there is some evidence that sufentanil is clinically superior to fentanyl as an adjunct to bupivacaine in labor epidurals, although the advantages are subtle.
Clinical Trials Related to Sufenta (Sufentanil)
A Randomized, Double-Blind Comparison of Morphine and Sufentanil for Prehospital Traumatic Severe Acute Pain [Recruiting]
Obtaining high-quality analgesia in prehospital patients with severe pain is an important
treatment objective for medical team. Opioids are recognized as the treatment of choice for
relief of severe acute pain. Recommended initial analgesia of patients with severe acute
pain, defined as a visual analog scale or a numerical rating scale (NRS) score of 60/100 or
higher, in a prehospital setting in France consists of the administration of opioids by the
medical staff of mobile intensive care units. The intravenous administration of morphine is
usually considered as the gold standard for postoperative acute pain relief because of its
rapid transport from the blood to target tissues after intravenous injection, its
long-lasting analgesic effect without any plateau, and its well-known pharmacokinetics.
Nevertheless, the short-acting opioid sufentanil might be preferable to the traditional
long-acting morphine for prehospital analgesia because of its even faster onset of action
and shorter duration than morphine. There is no study, to our knowledge, comparing the
clinical efficacy of sufentanil vs morphine in a prehospital setting. This randomized
double-blind group clinical trial is designed to determine the best intravenous opioid
titration protocol by comparing sufentanil and morphine for medical prehospital treatment of
adult patients with severe acute pain. Eligible patients with a numerical rating scale (NRS)
score of 60/100 or higher will be randomly allocated to receive either 0. 15 µg/kg sufentanil
then 0. 075 µg/kg every 3 minutes (group A) or 0. 15 mg/kg morphine then 0. 075 mg/kg every 3
minutes (group B) intravenously. The decision to provide opioid analgesia including
titration of subsequent doses of narcotic is the responsibility of physicians and
intravenous analgesia will be given and titrated according to the pain score every 3
minutes. The drugs will be administered by the physician from syringes of similar appearance
prepared by the nurse who is not otherwise involved in the study. The protocol-defined
primary outcome measure is the percentage of patients with pain relief (with a NRS score of
30/100 or lower) 15 minutes after the first injection. Secondary outcomes include pain score
comparisons every 3 minutes within the first 30 minutes and comparison of adverse events.
The physician blinded to the analgesic treatment groups will do all assessments of patients.
The safety evaluation will include non invasive monitoring of blood pressure, heart rate,
respiratory rate, oxygen saturation by pulse oximetry (Spo2), and a sedation scale (0,
patient is awake; 1, patient is with intermittent sleeping; 2, patient is sleeping, awakened
by verbal stimulation; 3, patient is sleeping, awakened by tactile stimulation; 4, patient
is not aroused by stimulation) at these periods. Fifteen minutes after the first injection,
overall patient and investigator satisfaction with analgesia was recorded.
A Safety and Efficacy Study of Sufentanil Transdermal System in Patients With Chronic Pain Due to Cancer [Not yet recruiting]
The study hypothesis is that the safety and efficacy of sufentanil following transdermal
application is comparable to sustained release morphine sulphate tablets in patients with
chronic pain due to cancer.
Epidural Labor Analgesia and Infant Neurobehavior [Recruiting]
Infant neurobehavior alteration is predictor of later intelligence development. Many factors
would influence or are associated with infant neurobehavior, of which exist or appear during
perinatal period. Neuraxial, especially epidural, analgesia to date is the most effective
method in relieving labor pain. Although previous studies showed that opioid used in
epidural analgesia for labor pain can affect newborn neurobehavior negatively in a
dose-escalation associated manner, whether epidural analgesia itself would produce
unpredictable effect on newborn neurobehavior is still unknown. Hereby the investigators
designed this trial to investigate the hypothesis that epidural analgesia for labor pain
control itself would not produce negative effect on infant neurobehavior.
Influence of Intraoperative Analgesia on the Postoperative Morphine Consumption [Recruiting]
Unlike longer acting opiates (sufentanil), remifentanil may provoke postoperative
hyperalgesia. We have developed two automated bispectral index - guided drug delivery
systems: one for propofol administration, the other for combined propofol and remifentanil
administration. Both systems achieve the same objective: similar level of anesthesia
indicated by bispectral index levels between 40 to 60. We make the assumption that this
method of automated remifentanil administration may avoid postoperative hyperalgesia.
Patients scheduled for abdominal surgery will be divided into two groups:
- in one group, patients will receive automatically delivered propofol and manually
delivered sufentanil according to the usual criteria,
- in the other group, patients will receive propofol and remifentanil both automatically
administered.
Assessment of postoperative hyperalgesia will be primarily based on morphine consumption
(patient controlled analgesia) and detection of cutaneous hyperalgesia areas.
Safety of Driving After Minor Surgery With Monitored Anesthesia Care [Recruiting]
Patients are currently advised to refrain from driving motor vehicles or using public
transportation unescorted for a 24 hour period if they undergo any minor ambulatory surgical
procedure with monitored anesthesia care (MAC).However, recently introduced short-acting
anesthetics may facilitate rapid recovery and an early return to normal daily activities.
The proposed study will compare newer short-acting anesthetic agents (propofol,
benzodiazepine, opioid) utilized in MAC, to determine if a particular pharmacological agent,
or a combination of agents, impair driving performance as evaluated by driving simulator
assessment, at time of discharge from the ambulatory center after minor surgical procedures.
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