DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Striant (Testosterone Buccal System) - Summary

 
 



STRIANT SUMMARY

Striant® (testosterone buccal system) is designed to adhere to the gum or inner cheek. It provides a controlled and sustained release of testosterone through the buccal mucosa as the buccal system gradually hydrates. Insertion of Striant® twice a day, in the morning and in the evening, provides continuous systemic delivery of testosterone.

Striant® is indicated for replacement therapy in males for conditions associated with a deficiency or absence of endogenous testosterone:

Primary hypogonadism (congenital or acquired) - testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, orchidectomy, Klinefelter's syndrome, chemotherapy, or toxic damage from alcohol or heavy metals. These men usually have low serum testosterone levels and gonadotropins (FSH, LH) above the normal range.

Hypogonadotropic hypogonadism (congenital or acquired) -- idiopathic gonadotropin or LHRH deficiency, or pituitary hypothalamic injury from tumors, trauma, or radiation. These patients have low serum testosterone levels but have gonadotropins in the normal or low range.


See all Striant indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Striant (Testosterone)

Testosterone supplementation does not result in progression of atherosclerosis
Source: Endocrinology News From Medical News Today [2015.08.12]
Among older men with low testosterone levels, testosterone administration for 3 years compared with placebo did not result in a significant difference in the rates of change in atherosclerosis...

Testosterone therapy may improve heart health for older men
Source: Stroke News From Medical News Today [2015.08.12]
Researchers have observed that patients whose low testosterone levels returned to normal with therapy also experienced a reduced risk of heart attack and stroke.

Normalization of testosterone level after testosterone replacement therapy
Source: Endocrinology News From Medical News Today [2015.08.06]
Normalization of testosterone level after testosterone replacement therapy could decrease risk of cardiovascular events and mortality in menPatients with low testosterone levels who have then...

Testosterone Treatments Won't Help Men With Ejaculatory Issues
Source: MedicineNet Clinical Trials Specialty [2015.07.10]
Title: Testosterone Treatments Won't Help Men With Ejaculatory Issues
Category: Health News
Created: 7/9/2015 12:00:00 AM
Last Editorial Review: 7/10/2015 12:00:00 AM

Men with 'low testosterone' have higher rates of depression
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today [2015.07.02]
Researchers at the George Washington University (GW), led by Michael S. Irwig, M.D.

more news >>

Published Studies Related to Striant (Testosterone)

Testosterone replacement therapy in older male subjective memory complainers: double-blind randomized crossover placebo-controlled clinical trial of physiological assessment and safety. [2015]
Testosterone replacement therapy (TRT) has been investigated in older men as a preventative treatment against Alzheimer's disease and dementia. However, previous studies have been contradictory... Our study suggests TRT is safe and well-tolerated in this Indonesian cohort, yet longitudinal studies with larger cohorts are needed to assess TRT further, and to establish whether TRT reduces dementia risk.

Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point. [2014]
hematocrit remain unclear... CONCLUSIONS: Testosterone-induced increase in hemoglobin and hematocrit is

Effect of testosterone treatment on constitutional and sexual symptoms in men with type 2 diabetes in a randomized, placebo-controlled clinical trial. [2014]
constitutional and sexual symptoms in men with type 2 diabetes (T2D)... CONCLUSIONS: In this trial, T treatment did not substantially improve

The role of androgen receptor CAG repeat polymorphism and other factors which affect the clinical response to testosterone replacement in metabolic syndrome and type 2 diabetes: TIMES2 sub-study. [2013]
TRT in the TIMES2 study... CONCLUSION: AR CAG affected the response of some variables to TRT in the TIMES2

Mechanical muscle function and lean body mass during supervised strength training and testosterone therapy in aging men with low-normal testosterone levels. [2013]
24-week study... CONCLUSION: Strength training in aging men with low-normal testosterone levels

more studies >>

Clinical Trials Related to Striant (Testosterone)

Effect of Androgel on Type 2 Diabetic Males With Hypogonadism [Active, not recruiting]
This is to study the effect of replacing testosterone on different inflammatory cells in type 2 diabetics with low testosterone levels.

Safety Study of Transdermal Testosterone for Low Libido in Pre and Postmenopausal Women [Completed]
Female sexual dysfunction (FSD) is an established side effect of Selective serotonin reuptake inhibitors (SSRIs) and serotonin noradrenalin reuptake inhibitors (SNRIs), causing symptoms such as loss of libido, arousal difficulties, or delayed orgasm or anorgasmia. Efficacy of testosterone therapy for the treatment of hypoactive sexual desire disorder (HSDD) in women has been demonstrated in studies including naturally and surgically menopausal women, either alone or in combination with estrogen, with or without progestin therapy.

TRADE-Testosterone Replacement and Dutasteride Effectiveness [Completed]
The purpose of this research study is to determine whether the combination of the male hormone testosterone [T] in gel form and the oral drug dutasteride [D], used to shrink large prostate glands can safely reduce the size of the prostate gland and symptoms of prostate enlargement (called benign prostatic hyperplasia [BPH]) compared to T treatment alone in men with low testosterone (called hypogonadism).

Pharmacokinetic Study of Testosterone Enanthate [Completed]

Anabolic and Inflammatory Responses to Short-Term Testosterone Administration in Older Men [Recruiting]
Skeletal muscle loss is a common consequence of aging and in some individuals reaches a level that compromises health and quality of life. Age-associated increases in cytokine and inflammatory signaling may be important contributors to this process. In this project the investigators will test the hypotheses that 1) testosterone will inhibit cytokine and inflammatory signaling in skeletal muscles of older adults and 2) will augment the anabolic response to increased skeletal muscle activity. The investigators will also assess the practical question of whether testosterone injection and gel application elicit similar responses. Resistance exercise will be used as a means of stimulating both inflammatory and anabolic responses in skeletal muscle. In order to assess the effects of testosterone on these responses, fourteen subjects will perform resistance exercise on two occasions separated by 7 days. The first session will be performed prior to the initiation of testosterone therapy and the second session will be performed after receiving testosterone for 7 days.

more trials >>


Page last updated: 2015-08-12

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2015