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Striant (Testosterone Buccal System) - Summary

 
 



STRIANT SUMMARY

Striant® (testosterone buccal system) is designed to adhere to the gum or inner cheek. It provides a controlled and sustained release of testosterone through the buccal mucosa as the buccal system gradually hydrates. Insertion of Striant® twice a day, in the morning and in the evening, provides continuous systemic delivery of testosterone.

Striant® is indicated for replacement therapy in males for conditions associated with a deficiency or absence of endogenous testosterone:

Primary hypogonadism (congenital or acquired) - testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, orchidectomy, Klinefelter's syndrome, chemotherapy, or toxic damage from alcohol or heavy metals. These men usually have low serum testosterone levels and gonadotropins (FSH, LH) above the normal range.

Hypogonadotropic hypogonadism (congenital or acquired) -- idiopathic gonadotropin or LHRH deficiency, or pituitary hypothalamic injury from tumors, trauma, or radiation. These patients have low serum testosterone levels but have gonadotropins in the normal or low range.


See all Striant indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Striant (Testosterone)

Low Testosterone (Low T) Treatments
Source: MedicineNet Chemotherapy Specialty [2016.08.19]
Title: Low Testosterone (Low T) Treatments
Category: Slideshows
Created: 11/28/2012 12:00:00 AM
Last Editorial Review: 8/19/2016 12:00:00 AM

Testosterone may be key to maintaining sexual function in older men
Source: Endocrinology News From Medical News Today [2016.07.01]
Testosterone therapy has been used for years, but research into its effect on sexual dysfunction in older men is scarce. A new study brings good news.

Testosterone Therapy May Boost Older Men's Sex Lives
Source: MedicineNet Hormone Therapy Specialty [2016.06.30]
Title: Testosterone Therapy May Boost Older Men's Sex Lives
Category: Health News
Created: 6/29/2016 12:00:00 AM
Last Editorial Review: 6/30/2016 12:00:00 AM

Prostate cancer: Testosterone therapy 'does not increase aggressive disease risk'
Source: Prostate / Prostate Cancer News From Medical News Today [2016.05.09]
A study using Swedish data finds men prescribed testosterone for over a year had no overall rise in prostate cancer risk, and they showed a 50 percent fall in aggressive disease.

Low Testosterone (Low T)
Source: MedicineNet Klinefelter Syndrome Specialty [2016.03.23]
Title: Low Testosterone (Low T)
Category: Diseases and Conditions
Created: 12/14/2009 12:00:00 AM
Last Editorial Review: 3/23/2016 12:00:00 AM

more news >>

Published Studies Related to Striant (Testosterone)

Testosterone replacement therapy in older male subjective memory complainers: double-blind randomized crossover placebo-controlled clinical trial of physiological assessment and safety. [2015]
Testosterone replacement therapy (TRT) has been investigated in older men as a preventative treatment against Alzheimer's disease and dementia. However, previous studies have been contradictory... Our study suggests TRT is safe and well-tolerated in this Indonesian cohort, yet longitudinal studies with larger cohorts are needed to assess TRT further, and to establish whether TRT reduces dementia risk.

Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point. [2014]
hematocrit remain unclear... CONCLUSIONS: Testosterone-induced increase in hemoglobin and hematocrit is

Effect of testosterone treatment on constitutional and sexual symptoms in men with type 2 diabetes in a randomized, placebo-controlled clinical trial. [2014]
constitutional and sexual symptoms in men with type 2 diabetes (T2D)... CONCLUSIONS: In this trial, T treatment did not substantially improve

The role of androgen receptor CAG repeat polymorphism and other factors which affect the clinical response to testosterone replacement in metabolic syndrome and type 2 diabetes: TIMES2 sub-study. [2013]
TRT in the TIMES2 study... CONCLUSION: AR CAG affected the response of some variables to TRT in the TIMES2

Mechanical muscle function and lean body mass during supervised strength training and testosterone therapy in aging men with low-normal testosterone levels. [2013]
24-week study... CONCLUSION: Strength training in aging men with low-normal testosterone levels

more studies >>

Clinical Trials Related to Striant (Testosterone)

Effect of Androgel on Type 2 Diabetic Males With Hypogonadism [Active, not recruiting]
This is to study the effect of replacing testosterone on different inflammatory cells in type 2 diabetics with low testosterone levels.

Safety Study of Transdermal Testosterone for Low Libido in Pre and Postmenopausal Women [Completed]
Female sexual dysfunction (FSD) is an established side effect of Selective serotonin reuptake inhibitors (SSRIs) and serotonin noradrenalin reuptake inhibitors (SNRIs), causing symptoms such as loss of libido, arousal difficulties, or delayed orgasm or anorgasmia. Efficacy of testosterone therapy for the treatment of hypoactive sexual desire disorder (HSDD) in women has been demonstrated in studies including naturally and surgically menopausal women, either alone or in combination with estrogen, with or without progestin therapy.

TRADE-Testosterone Replacement and Dutasteride Effectiveness [Completed]
The purpose of this research study is to determine whether the combination of the male hormone testosterone [T] in gel form and the oral drug dutasteride [D], used to shrink large prostate glands can safely reduce the size of the prostate gland and symptoms of prostate enlargement (called benign prostatic hyperplasia [BPH]) compared to T treatment alone in men with low testosterone (called hypogonadism).

Pharmacokinetic Study of Testosterone Enanthate [Completed]

Anabolic and Inflammatory Responses to Short-Term Testosterone Administration in Older Men [Recruiting]
Skeletal muscle loss is a common consequence of aging and in some individuals reaches a level that compromises health and quality of life. Age-associated increases in cytokine and inflammatory signaling may be important contributors to this process. In this project the investigators will test the hypotheses that 1) testosterone will inhibit cytokine and inflammatory signaling in skeletal muscles of older adults and 2) will augment the anabolic response to increased skeletal muscle activity. The investigators will also assess the practical question of whether testosterone injection and gel application elicit similar responses. Resistance exercise will be used as a means of stimulating both inflammatory and anabolic responses in skeletal muscle. In order to assess the effects of testosterone on these responses, fourteen subjects will perform resistance exercise on two occasions separated by 7 days. The first session will be performed prior to the initiation of testosterone therapy and the second session will be performed after receiving testosterone for 7 days.

more trials >>


Page last updated: 2016-08-19

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