Streptomycin (Streptomycin) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

The following reactions are common: vestibular ototoxicity (nausea, vomiting, and vertigo); paresthesia of face; rash; fever; urticaria; angioneurotic edema; and eosinophilia.

The following reactions are less frequent: cochlear ototoxity (deafness); exfoliative dermatitis; anaphylaxis; azotemia; leucopenia; thrombocytopenia; pancytopenia; hemolytic anemia; muscular weakness; and amblyopia.

Vestibular dysfunction resulting from the parenteral administration of streptomycin is cumulatively related to the total daily dose. When 1.8 to 2 g/day are given, symptoms are likely to develop in the large percentage of patients–especially in the elderly or patients with impaired renal function–within four weeks. Therefore, it is recommended that caloric and audiometric tests be done prior to, during, and following intensive therapy with streptomycin in order to facilitate detection of any vestibular dysfunction and/or impairment of hearing which may occur.

Vestibular symptoms generally appear early and usually are reversible with early detection and cessation of streptomycin administration. Two to three months after stopping the drug, gross vestibular symptoms usually disappear, except for the relative inability to walk in total darkness or on very rough terrain.

Although streptomycin is the least nephrotoxic of the aminoglycosides, nephrotoxicity does occur rarely.

Clinical judgment as to termination of therapy must be exercised when side effects occur.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO STREPTOMYCIN

Possible Streptomycin side effects / adverse reactions in 34 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2007-04-18

Patient: 34 year old male

Reactions: Henoch-Schonlein Purpura

Suspect drug(s):
Isoniazid
    Indication: Pulmonary Tuberculosis

Streptomycin
    Indication: Pulmonary Tuberculosis

Ethambutol Hydrochloride
    Indication: Pulmonary Tuberculosis

Rifampicin
    Indication: Pulmonary Tuberculosis

Corticosteroid
    Indication: Pulmonary Tuberculosis

Possible Streptomycin side effects / adverse reactions in 58 year old male

Reported by a individual with unspecified qualification from Japan on 2007-06-11

Patient: 58 year old male

Reactions: Immune Reconstitution Syndrome, Herpes Zoster Disseminated

Suspect drug(s):
Rimactane
    Dosage: dose: unk
    Indication: Pulmonary Tuberculosis

Pyramide
    Dosage: dose: unk
    Indication: Pulmonary Tuberculosis

Iscotin /00030201/
    Dosage: dose: unk
    Indication: Pulmonary Tuberculosis

Streptomycin
    Dosage: dose: unk
    Indication: Pulmonary Tuberculosis

Ethambutol Hydrochloride
    Dosage: dose: unk
    Indication: Pulmonary Tuberculosis

Possible Streptomycin side effects / adverse reactions in 50 year old female

Reported by a health professional (non-physician/pharmacist) from Italy on 2007-10-16

Patient: 50 year old female

Reactions: Deafness Bilateral, Dizziness, Areflexia

Suspect drug(s):
Streptomycin