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Streptomycin (Streptomycin) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

The following reactions are common: vestibular ototoxicity (nausea, vomiting, and vertigo); paresthesia of face; rash; fever; urticaria; angioneurotic edema; and eosinophilia.

The following reactions are less frequent: cochlear ototoxicity (deafness); exfoliative dermatitis; anaphylaxis; azotemia; leucopenia; thrombocytopenia; pancytopenia; hemolytic anemia; muscular weakness; and amblyopia.

Vestibular dysfunction resulting from the parenteral administration of streptomycin is cumulatively related to the total daily dose. When 1.8 to 2 g/day are given, symptoms are likely to develop in the large percentage of patients - especially in the elderly or patients with impaired renal function - within four weeks. Therefore, it is recommended that caloric and audiometric tests be done prior to, during, and following intensive therapy with streptomycin in order to facilitate detection of any vestibular dysfunction and/or impairment of hearing which may occur.

Vestibular symptoms generally appear early and usually are reversible with early detection and cessation of streptomycin administration. Two to three months after stopping the drug, gross vestibular symptoms usually disappear, except from the relative inability to walk in total darkness or on very rough terrain.

Although streptomycin is the least nephrotoxic of the aminoglycosides, nephrotoxicity does occur rarely.

Clinical judgment as to termination of therapy must be exercised when side effects occur.



REPORTS OF SUSPECTED STREPTOMYCIN SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Streptomycin. The information is not vetted and should not be considered as verified clinical evidence.

Possible Streptomycin side effects / adverse reactions in 2 year old female

Reported by a health professional (non-physician/pharmacist) from Spain on 2011-10-13

Patient: 2 year old female weighing 10.9 kg (24.0 pounds)

Reactions: Lymphadenopathy, Central Nervous System Lesion, Disseminated Tuberculosis, Pyrexia, Computerised Tomogram Abnormal, Treatment Noncompliance, Disease Progression, Lung Consolidation, Interstitial Lung Disease, Paradoxical Drug Reaction, Hilar Lymphadenopathy, Pleural Effusion, Lung Infiltration, Cough

Adverse event resulted in: hospitalization

Suspect drug(s):
Isoniazid
    Dosage: 10.2 mg/kg;qd
    Indication: Pulmonary Tuberculosis

Pyrazinamide
    Dosage: 22.7 mg/kg;qd
    Indication: Pulmonary Tuberculosis

Streptomycin
    Indication: Pulmonary Tuberculosis

Rifampin
    Dosage: 14 mg/kg;qd
    Indication: Pulmonary Tuberculosis



Possible Streptomycin side effects / adverse reactions in 48 year old male

Reported by a health professional (non-physician/pharmacist) from Morocco on 2011-10-26

Patient: 48 year old male weighing 57.0 kg (125.4 pounds)

Reactions: Refusal of Treatment by Patient, Skin Toxicity, Circulatory Collapse, Fall, Pemphigoid

Adverse event resulted in: hospitalization

Suspect drug(s):
Isoniazid
    Dosage: 300 mg;qd
    Indication: Pulmonary Tuberculosis

Pyrazinamide
    Dosage: 1500 mg;qd
    Indication: Pulmonary Tuberculosis

Rifampin
    Dosage: 600 mg;qd
    Indication: Pulmonary Tuberculosis

Streptomycin
    Dosage: 1000 mg;qd
    Indication: Pulmonary Tuberculosis



Possible Streptomycin side effects / adverse reactions in 61 year old female

Reported by a physician from Korea, Republic of on 2011-11-03

Patient: 61 year old female weighing 43.0 kg (94.6 pounds)

Reactions: Hepatotoxicity, Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: hospitalization

Suspect drug(s):
Levofloxacin
    Indication: Tuberculosis
    Start date: 2011-01-20
    End date: 2011-03-22

Isoniazid
    Start date: 2011-01-20

Cycloserine
    Start date: 2011-04-11
    End date: 2011-04-12

Levofloxacin
    Start date: 2011-04-11
    End date: 2011-04-12

Rifampin
    Indication: Tuberculosis
    Start date: 2011-01-20
    End date: 2011-03-22

Isoniazid
    Indication: Tuberculosis
    Start date: 2011-04-28

Isoniazid
    Start date: 2011-04-18
    End date: 2011-04-19

Cycloserine
    Indication: Tuberculosis
    Start date: 2011-05-13

Streptomycin
    Indication: Tuberculosis
    Start date: 2011-04-11
    End date: 2011-04-12

Pyridoxine HCL
    Indication: Tuberculosis
    Start date: 2011-03-29

Ethambutol Hydrochloride
    Start date: 2011-01-20
    End date: 2011-03-22

Streptomycin
    Start date: 2011-01-20
    End date: 2011-03-22

Streptomycin
    Start date: 2011-05-09
    End date: 2011-05-09

Ethambutol Hydrochloride
    Indication: Tuberculosis
    Start date: 2011-04-11
    End date: 2011-04-12

Pyrazinamide
    Indication: Tuberculosis
    Start date: 2011-01-20

Amikacin
    Indication: Tuberculosis

Other drugs received by patient: Concor; Prothionamide; Omeprazole



See index of all Streptomycin side effect reports >>

Drug label data at the top of this Page last updated: 2013-05-14

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