DRUG INTERACTIONS
Drug interaction studies have not been conducted with STELARA™.
Live Vaccines
Live vaccines should not be given concurrently with STELARA™ [see Warnings and Precautions].
Concomitant Therapies
The safety of STELARA™ in combination with immunosuppressive agents or phototherapy has not been evaluated [see Warnings and Precautions].
CYP450 Substrates
The formation of CYP450 enzymes can be altered by increased levels of certain cytokines (e.g., IL-1, IL-6, IL-10, TNFalpha, IFN) during chronic inflammation. Thus, ustekinumab could normalize the formation of CYP450 enzymes. A role for IL-12 or IL-23 in the regulation of CYP450 enzymes has not been reported. However, upon initiation of ustekinumab in patients who are receiving concomitant CYP450 substrates, particularly those with a narrow therapeutic index, monitoring for therapeutic effect (e.g., for warfarin) or drug concentration (e.g., for cyclosporine) should be considered and the individual dose of the drug adjusted as needed [see Clinical Pharmacology].
|
