Media Articles Related to Stalevo (Carbidopa / Levodopa / Entacapone)
Differentiating Parkinson's disease from atypical parkinsonism - simple clinical tests
Source: Primary Care / General Practice News From Medical News Today [2014.11.20]
Two simple tests conducted during the neurological exam can help clinicians differentiate between early-stage Parkinson's disease (PD) and atypical parkinsonism.
'Medium' daily exercise tied to lower risk of Parkinson's disease
Source: Sports Medicine / Fitness News From Medical News Today [2014.11.19]
A new study finds medium amounts of daily physical exercise from doing chores, commuting and leisure pursuits is associated with a reduced risk of developing Parkinson's disease.
Parkinson's disease in a dish
Source: Stem Cell Research News From Medical News Today [2014.11.10]
A team of scientists led by The New York Stem Cell Foundation (NYSCF) Research Institute successfully created a human stem cell disease model of Parkinson's disease in a dish.
The inhibition of a mitochondrial fission protein shows promise as a potential treatment for Parkinson's disease
Source: Huntingtons Disease News From Medical News Today [2014.11.08]
A study led by a researcher from Plymouth University in the UK, has discovered that the inhibition of a particular mitochondrial fission protein could hold the key to potential treatment for...
New gene linked to blindness and Parkinson's diseases
Source: Eye Health / Blindness News From Medical News Today [2014.10.24]
The retinal pigment epithelium (RPE) is a tissue, which lines the back of the eye.
Published Studies Related to Stalevo (Carbidopa / Levodopa / Entacapone)
Long-term outcome of early versus delayed rasagiline treatment in early Parkinson's disease. [2009.03.15]
The purpose of this study to compare the long-term clinical outcome of early versus delayed rasagiline treatment in early Parkinson's disease (PD). Subjects (N = 404) were randomly assigned to initial treatment with rasagiline (early-start group) or placebo for 6 months followed by rasagiline (delayed-start group) in the TEMPO study...
Entacapone prolongs the reduction of PLM by levodopa/carbidopa in restless legs syndrome. [2007.11]
OBJECTIVES: Levodopa is effective in the treatment of restless legs syndrome (RLS). However, due to the short duration of action of conventional levodopa/decarboxylase inhibitor formulations, multiple dosing may be required in individual patients with persisting symptoms. We assessed whether a new levodopa formulation containing levodopa, carbidopa, and entacapone (LCE) improves levodopa action in RLS... CONCLUSIONS: Single doses of LCE tablets decreased PLMs in a dose-related manner in RLS patients. Prolonged effects of levodopa on PLMs suggest that, compared with standard levodopa, this new levodopa formulation provides longer symptom control throughout the night in patients with previously untreated RLS.
Treatment of end-of-dose wearing-off in parkinson's disease: stalevo (levodopa/carbidopa/entacapone) and levodopa/DDCI given in combination with Comtess/Comtan (entacapone) provide equivalent improvements in symptom control superior to that of traditional levodopa/DDCI treatment. 
The aim of this study was to evaluate the efficacy of the new optimised levodopa, Stalevo (levodopa, carbidopa and entacapone) in patients with Parkinson's disease experiencing end-of-dose wearing-off. Treatment with Stalevo was compared to treatment with traditional immediate-release levodopa and dopa-decarboxylase inhibitor (DDCI) formulations along with adjunct entacapone (Comtess/Comtan)...
Determination of L-dopa, carbidopa, 3-O-methyldopa and entacapone in human plasma by HPLC-ED. [2011.02.20]
The aim of the study was the development of analytical methods suitable for the quantification of L-dopa, carbidopa and entacapone in plasma of Parkinsonian patients treated with Stalevo((R)). The metabolite 3-O-methyldopa was also determined to obtain some indications on the pharmacokinetics of L-dopa...
[The effect of Stalevo-dosing on quality of life of Parkinsonian patients with wearing-off]. [2010.07.30]
In Stalevo tablets, used in the therapy of patients with Parkinson's disease, levodopa is combined with decarboxylase inhibitors and COMT inhibitors to provide a more steady plasma concentration of levodopa. Previously several study has shown, that the better pharmacokinetic profile decreases the fluctuation of motor and non-motor symptoms...
Clinical Trials Related to Stalevo (Carbidopa / Levodopa / Entacapone)
Study to Evaluate Initiation of Stalevo in Early Wearing-Off [Completed]
An open, non-randomised, multinational, multicentre direct switch study in levodopa-treated
Parkinson's disease patients suffering from early wearing-off in Parkinson's disease. The
study will consist of 2 consecutive periods: screening period and study treatment period.
Duration of the study will be up to 8 weeks for each subject. The study treatment dosage will
be determined by the subject's current, separately administered standard levodopa/DDCI
treatment (3-4 doses per day, maximum of total daily dose of 600 mg levodopa) which will be
switched to an equivalent dose of Stalevo« without changing the number of doses per day. The
levodopa daily dose during Stalevo┬« treatment may be adjusted according to the study
subject's clinical response.
Stalevo in Early Wearing-Off Patients [Active, not recruiting]
The purpose of this study is to demonstrate in patients with Parkinson's disease that, when
compared to levodopa/carbidopa, Stalevo will delay the time from initiation of study drug to
the time an increase in antiparkinsonian medication is required due to inadequately
controlled parkinsonian symptoms.
PET-Study: Effects of Single Doses of Stalevo and Levodopa/Carbidopa on Striatal 11C-Raclopride Binding [Terminated]
This is an open, randomised, active-controlled, 2-period crossover study comparing the effect
of single doses of Stalevo 200 and Sinemet on striatal (putamenal and caudate) 11C-raclopride
BP in PD patients with wearing-off symptoms. The study consists of 4 visits: a screening
visit (visit 1), 2 treatment periods (period 1=visit 2, period 2=visit 3) separated by a
minimum wash-out period of at least 3 days, and an end-of-study visit (visit 4). Subjects
will be randomly allocated to start the period 1 with a single dose of Stalevo 200 or
Sinemet. After the wash-out the study drug on period 2 will be administered according to a
Pharmacokinetic Study With Repeated Doses of Stalevo [Completed]
The purpose of this study is to show that higher minimum concentration values are obtained
following repeated doses of Stalevo 4 times daily compared to lecodopa/carbidopa treatment
with corresponding dosing regimen.
Adherence of Stalevo, Entacapone and Levodopa [Completed]
To test if combining two antiparkinson drugs into a single tablet improves accuracy of
medicine intake by the patient.
To test if patients with Parkinson's disease who take medicines at regular time intervals
have smoother symptom control.