Media Articles Related to Stalevo (Carbidopa / Levodopa / Entacapone)
Pharnext's pleodrug PXT-864 demonstrates positive effects in Parkinson's disease
Source: Clinical Trials / Drug Trials News From Medical News Today [2015.11.12]
Pharnext SAS has announced the publication of positive preclinical results in Nature's Scientific Reports for its pleodrug PXT-864 in Parkinson's disease.
Does alcohol consumption affect the risk for Parkinson's disease?
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2015.11.11]
For many years, researchers have been investigating whether there are any associations between Parkinson's disease (PD) and lifestyle choices such as smoking and coffee and alcohol consumption.
Gaucher disease may protect against Parkinson's disease-related color visual impairment
Source: Eye Health / Blindness News From Medical News Today [2015.11.11]
Parkinson's Disease (PD) patients have a five-fold greater risk of carrying genetic mutations in the ╬▓-glucocerebrosidase gene (GBA), which are commonly associated with Gaucher disease (GD).
Parkinson's Disease Quiz: Test Your Medical IQ
Source: MedicineNet amantadine Specialty [2015.02.20]
Title: Parkinson's Disease Quiz: Test Your Medical IQ
Category: MedicineNet Quiz
Created: 8/23/2011 12:53:00 PM
Last Editorial Review: 2/20/2015 4:38:06 PM
Scripps Florida scientists' 'mad cow' discovery points to possible neuron killing mechanism behind Alzheimer's and Parkinson's diseases
Source: CJD / vCJD / Mad Cow Disease News From Medical News Today [2015.02.16]
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time discovered a killing mechanism that could underpin a range of the most intractable...
Published Studies Related to Stalevo (Carbidopa / Levodopa / Entacapone)
Long-term outcome of early versus delayed rasagiline treatment in early Parkinson's disease. [2009.03.15]
The purpose of this study to compare the long-term clinical outcome of early versus delayed rasagiline treatment in early Parkinson's disease (PD). Subjects (N = 404) were randomly assigned to initial treatment with rasagiline (early-start group) or placebo for 6 months followed by rasagiline (delayed-start group) in the TEMPO study...
Entacapone prolongs the reduction of PLM by levodopa/carbidopa in restless legs syndrome. [2007.11]
OBJECTIVES: Levodopa is effective in the treatment of restless legs syndrome (RLS). However, due to the short duration of action of conventional levodopa/decarboxylase inhibitor formulations, multiple dosing may be required in individual patients with persisting symptoms. We assessed whether a new levodopa formulation containing levodopa, carbidopa, and entacapone (LCE) improves levodopa action in RLS... CONCLUSIONS: Single doses of LCE tablets decreased PLMs in a dose-related manner in RLS patients. Prolonged effects of levodopa on PLMs suggest that, compared with standard levodopa, this new levodopa formulation provides longer symptom control throughout the night in patients with previously untreated RLS.
Treatment of end-of-dose wearing-off in parkinson's disease: stalevo (levodopa/carbidopa/entacapone) and levodopa/DDCI given in combination with Comtess/Comtan (entacapone) provide equivalent improvements in symptom control superior to that of traditional levodopa/DDCI treatment. 
The aim of this study was to evaluate the efficacy of the new optimised levodopa, Stalevo (levodopa, carbidopa and entacapone) in patients with Parkinson's disease experiencing end-of-dose wearing-off. Treatment with Stalevo was compared to treatment with traditional immediate-release levodopa and dopa-decarboxylase inhibitor (DDCI) formulations along with adjunct entacapone (Comtess/Comtan)...
Determination of L-dopa, carbidopa, 3-O-methyldopa and entacapone in human plasma by HPLC-ED. [2011.02.20]
The aim of the study was the development of analytical methods suitable for the quantification of L-dopa, carbidopa and entacapone in plasma of Parkinsonian patients treated with Stalevo((R)). The metabolite 3-O-methyldopa was also determined to obtain some indications on the pharmacokinetics of L-dopa...
[The effect of Stalevo-dosing on quality of life of Parkinsonian patients with wearing-off]. [2010.07.30]
In Stalevo tablets, used in the therapy of patients with Parkinson's disease, levodopa is combined with decarboxylase inhibitors and COMT inhibitors to provide a more steady plasma concentration of levodopa. Previously several study has shown, that the better pharmacokinetic profile decreases the fluctuation of motor and non-motor symptoms...
Clinical Trials Related to Stalevo (Carbidopa / Levodopa / Entacapone)
Clock and Narcolepsy Genetic Variants and the Effects of Stalevo´┐Ż (Levodopa/Carbidopa/Entacapone) on Sleep Disorders in Parkinson's Disease [Active, not recruiting]
The purpose of this study is to investigate the genetic variants of clock and narcolepsy
genes that determine the therapeutic effects of Stalevo« on the quality of sleep in patients
with Parkinson's Disease.
Levodopa Concentration Profile With Stalevo 75/125 mg [Completed]
The purpose of this study is to confirm that the dose levels and dosing frequency utilising
the new Stalevo strengths would result into more stable levodopa plasma levels. Therefore,
it is anticipated that when lower dose of Stalevo is administered after the first higher
dose of Stalevo, this would result in equally high levodopa maximum concentration values
(Cmax) after each dose throughout the day compared to Cmax after the first dose.
Study to Evaluate Initiation of Stalevo in Early Wearing-off [Completed]
An open, non-randomised, multinational, multicentre direct switch study in levodopa-treated
Parkinson's disease patients suffering from early wearing-off in Parkinson's disease. The
study will consist of 2 consecutive periods: screening period and study treatment period.
Duration of the study will be up to 8 weeks for each subject. The study treatment dosage
will be determined by the subject's current, separately administered standard levodopa/DDCI
treatment (3-4 doses per day, maximum of total daily dose of 600 mg levodopa) which will be
switched to an equivalent dose of Stalevo┬« without changing the number of doses per day. The
levodopa daily dose during Stalevo┬« treatment may be adjusted according to the study
subject's clinical response.
Stalevo in Early Wearing-Off Patients [Completed]
The purpose of this study is to demonstrate in patients with Parkinson's disease that, when
compared to levodopa/carbidopa, Stalevo will delay the time from initiation of study drug to
the time an increase in antiparkinsonian medication is required due to inadequately
controlled parkinsonian symptoms.
Pharmacokinetic Study With Repeated Doses of Stalevo [Completed]
The purpose of this study is to show that higher minimum concentration values are obtained
following repeated doses of Stalevo 4 times daily compared to lecodopa/carbidopa treatment
with corresponding dosing regimen.