NEWS HIGHLIGHTS
Published Studies Related to Stadol (Butorphanol)
Analgesia after feline ovariohysterectomy under midazolam-medetomidine-ketamine
anaesthesia with buprenorphine or butorphanol, and carprofen or meloxicam: a
prospective, randomised clinical trial. [2012]
One hundred female cats undergoing routine ovariohysterectomy under
midazolam-medetomidine-ketamine anaesthesia were included in a blinded,
randomised, prospective clinical study to compare postoperative analgesia
produced by four analgesic drug combinations given preoperatively (n = 25 per
group)...
Individual differences in morphine and butorphanol analgesia: a laboratory pain study. [2011.07]
OBJECTIVE: Responses to opioid analgesics are highly variable, and the understanding of contributing factors is limited. This laboratory study was designed to examine the contributions of sex and race to inter-individual variability in response to opioids... CONCLUSIONS: Findings are among the first to demonstrate race differences in a laboratory study of opioid analgesia. Wiley Periodicals, Inc.
Evaluation of sedation and analgesia in standing horses after administration of xylazine, butorphanol, and subanesthetic doses of ketamine. [2011.06.15]
OBJECTIVE: To evaluate the sedative and analgesic effects of subanesthetic doses of ketamine in horses sedated with xylazine, with or without butorphanol... Further evaluation is needed to determine whether subanesthetic dosages of ketamine might be useful when performing certain clinical procedures in horses.
Post-operative analgesic effects of butorphanol or firocoxib administered to dogs undergoing elective ovariohysterectomy. [2011.05]
OBJECTIVE: To compare the post-operative analgesic effects of butorphanol or firocoxib in dogs undergoing ovariohysterectomy...
A clinical study on the effect in horses during medetomidine-isoflurane anaesthesia, of butorphanol constant rate infusion on isoflurane requirements, on cardiopulmonary function and on recovery characteristics. [2011.05]
OBJECTIVE: To test if the addition of butorphanol by constant rate infusion (CRI) to medetomidine-isoflurane anaesthesia reduced isoflurane requirements, and influenced cardiopulmonary function and/or recovery characteristics... CONCLUSION AND CLINICAL RELEVANCE: Butorphanol CRI at the dose used does not decrease isoflurane requirements in horses anaesthetised with medetomidine-isoflurane and has no influence on cardiopulmonary function or recovery.
Clinical Trials Related to Stadol (Butorphanol)
Propofol-Butorphanol Anesthesia During Uterine Curettage [Recruiting]
Uterine curettage is usually performed under the anesthesia of propofol-fentanyl or
para-cervical block,of which generally has significant incidence of respiratory depression
which increases the demand on intraoperative monitoring, or has unavoidable insufficient
blockade which results in intraoperative suffering of pain. Butorphanol is an analgesic with
combined effects on mu and kappa opioid receptors leading to a role as analgesia and
sedation. The investigators hypothesized that combined propofol with butorphanol during
uterine curettage would produce optimal effectiveness of these two drugs by adding sedative
and analgesic effects together. In addition, it would decrease the intraoperative consumption
of propofol without increase the incidence of side effects. Furthermore, such combination
would alleviate postoperative pain.
Comparing Sedara to Butorphanol in Early Labor [Not yet recruiting]
Nitrous oxide (N2O) has been used for the treatment of labor pains for over 150 years. The
longevity of its use in clinical practice can be attributed to its excellent safety profile,
ease of administration, and familiarity of use among health-care providers. Sedara is a
self-administered 50% N2O, 50% oxygen gas mixture with pain relieving and anxiety reducing
properties recently available for use in the United States (US) to treat various painful
clnical situations, including labor pains.
In the US, epidural or intravenous administration of narcotic medications is one of the most
common and frequently requested treatments for patients experiencing labor pains. Although
generally considered safe, complications are common with epidurals, including fetal
distress, low blood pressure in the mother, respiratory distress, and headache. In our
hospital system, the use of the synthetic intravenous painkiller, Butorphanol, is a mainstay
of treatment for labor pains. It too can have undesirable side effects in the mother,
including low blood pressure and breathing problems.
Because Sedara has until recently been unavailable in the US, studies comparing its efficacy
with other agents for labor pain have been confined to Europe, predominantly in the United
Kingdom. Several studies have investigated the efficacy of Sedara versus inhalation and
intravenous anesthetics in various countries. We have obtained several Sedara devices for
use in the West Penn Allegheny Health System (WPAHS) Department of Anesthesiology and would
like to examine its efficacy in our target population of women experiencing pain during
early labor.
Hypothesis - Sedara will provide equivalent or superior pain relief among term, adult
parturients in early labor (less than 5cm cervical dilation) compared to intravenous
butorphanol.
Primary aim - Compare Sedara versus butorphanol in a single-blinded randomized trial with
the main outcome measure being reduction in labor pains at various time intervals.
Our findings may be significant in terms of improving safety and efficacy of pain relief
among women experienceing labor pains. Given that Sedara has not been previously studied in
the US, the results may influence current obstetrical and pain management practices.
Comparison of Butorphanol and Tramadol Associated PCA After Hysterectomy [Completed]
Intravenous patient-controlled analgesia (PCA) is a popular technique for postoperative pain
management. Although several drugs are recognized as effective therapeutic options, optimal
selection of drugs in hysterectomy patients underwent different anesthesia treatments remains
unknown explicitly. We hypothesized that butorphanol and tramadol can produce different
analgesic effects with intravenous PCA after abdominal hysterectomy.
Comparison of Analgesic Efficacy of Fentanyl, Sufentanil and Butorphanol After Remifentanil Anesthesia [Recruiting]
Fast awakening from anesthesia is one of the major characteristics of remifentanil-associated
anesthetic induction and maintenance, whereas corresponding pain during awakening influences
patient's rehabilitation strongly. In addition, such early postoperative pain results in
significant stress responses, which displays as further release of stress hormones such as
cortisol and β-endorphin as well. How to prevent such acute pain resulting from
remifentanil's fast metabolism endows clinical significance. This study is designed to
compare the analgesic efficacy of fentanyl, sufentanil and butorphanol delivered after
gynecological laparoscopic surgeries that underwent remifentanil induction and maintenance,
and investigate corresponding influence on the levels of blood cortisol and β-endorphin.
Comparison of Pain Therapeutic Effects After Benign Mastectomy [Completed]
With the incremental trend of benign breast tumor, the surgical process of mastectomy was
proceeded too much every day, especially in the Maternal Health Care Hospital, but whether
can find one way to relief the postoperative pain after such operation is still unknown. We
hypothesized that the pain from the relatively small surgery may not be significant compared
with different treatments, even no drug was delivered to them. So then we are enrolling
patients who underwent mastectomy from benign breast tumor, and observing the analgesic
effects of different drugs.
Reports of Suspected Stadol (Butorphanol) Side Effects
Drug Hypersensitivity (7),
Somnolence (4),
Cardiac Disorder (3),
Paranoia (3),
Prostatic Disorder (3),
Feeling Abnormal (3),
NO Adverse Event (2),
Spinal Disorder (2),
Wrong Drug Administered (1),
Cyanosis (1), more >>
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