Somavert Related Published Studies
Well-designed clinical trials related to Somavert (Pegvisomant)
Cotreatment with pegvisomant and a somatostatin analog (SA) in SA-responsive acromegalic patients. [2011.08]
Comparison of pegvisomant and long-acting octreotide in patients with acromegaly naive to radiation and medical therapy. [2009.12]
A randomized, controlled, multicentre trial comparing pegvisomant alone with combination therapy of pegvisomant and long-acting octreotide in patients with acromegaly. [2009.10]
Quality of life in acromegalic patients during long-term somatostatin analog treatment with and without pegvisomant. [2008.10]
Pegvisomant for the treatment of gsp-mediated growth hormone excess in patients with McCune-Albright syndrome. [2006.08]
Glucose homeostasis and safety in patients with acromegaly converted from long-acting octreotide to pegvisomant. [2005.10]
High levels of 150-kDa insulin-like growth factor binding protein three ternary complex in patients with acromegaly and the effect of pegvisomant-induced serum IGF-I normalization. [2004.02]
A comparison of the effects of pegvisomant and octreotide on glucose, insulin, gastrin, cholecystokinin, and pancreatic polypeptide responses to oral glucose and a standard mixed meal. [2002.04]
Cardiovascular risk factors in acromegaly before and after normalization of serum IGF-I levels with the GH antagonist pegvisomant. [2002.04]
Acute effect of pegvisomant on cardiovascular risk markers in healthy men: implications for the pathogenesis of atherosclerosis in GH deficiency. [2001.11]
Effects of fasting and pegvisomant on the GH-releasing hormone and GH-releasing peptide-6 stimulated growth hormone secretion. [2001.10]
Lowering total plasma insulin-like growth factor I concentrations by way of a novel, potent, and selective growth hormone (GH) receptor antagonist, pegvisomant (B2036-peg), augments the amplitude of GH secretory bursts and elevates basal/nonpulsatile GH release in healthy women and men. [2001.07]
Modulation of cortisol metabolism by the growth hormone receptor antagonist pegvisomant in patients with acromegaly. [2001.07]
Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. [2000.04.20]
Well-designed clinical trials possibly related to Somavert (Pegvisomant)
GH receptor blocker administration and muscle-tendon collagen synthesis in humans. [2011.06]
Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects. [2009.11]
Growth hormone receptor antagonist treatment reduces exercise performance in young males. [2009.09]
Use of a GH receptor antagonist (GHRA) to explore the relationship between GH and IGF-I in adults with severe GH deficiency (GHD). [2009.03]
The effects of GH and hormone replacement therapy on serum concentrations of mannan-binding lectin, surfactant protein D and vitamin D binding protein in Turner syndrome. [2004.03]
The effects of a specific growth hormone antagonist on overnight insulin requirements and insulin sensitivity in young adults with Type 1 diabetes mellitus. [2003.09]
Lessons from 6 years of GH receptor antagonist therapy for acromegaly. [2003]
Impact of experimental blockade of peripheral growth hormone (GH) receptors on the kinetics of endogenous and exogenous GH removal in healthy women and men. [2002.12]
Effects of a growth hormone receptor antagonist on bone markers in acromegaly. [2002.09]
GH strongly affects serum concentrations of mannan-binding lectin: evidence for a new IGF-I independent immunomodulatory effect of GH. [2001.11]
Growth hormone receptor antagonist therapy in acromegalic patients resistant to somatostatin analogs. [2000.08]
Other research related to Somavert (Pegvisomant)
Combination treatment with somatostatin analogues and pegvisomant in acromegaly. [2011.06]
Coadministration of lanreotide Autogel and pegvisomant normalizes IGF1 levels and is well tolerated in patients with acromegaly partially controlled by somatostatin analogs alone. [2011.03]
Somatotroph tumor progression during pegvisomant therapy: a clinical and molecular study. [2011.02]
Inhibition of growth hormone receptor activation by pegvisomant may increase bone density in acromegaly. [2011.01]
Influence of pegvisomant on serum ghrelin and leptin levels in acromegalic patients. [2010.11]
The acute effect of a single application of cabergoline on endogenous GH levels in patients with acromegaly on pegvisomant treatment. [2010.10]
Change of symptoms and perceived health in acromegalic patients on pegvisomant therapy: a retrospective cohort study within the German Pegvisomant Observational Study (GPOS). [2010.07]
Pegvisomant-induced liver injury is related to the UGT1A1*28 polymorphism of Gilbert's syndrome. [2010.05]
Skin reaction and fever after treatment with pegvisomant in a patient with acromegaly. [2010.02]
Tumor volume of growth hormone-secreting pituitary adenomas during treatment with pegvisomant: a prospective multicenter study. [2010.02]
The exon 3-deleted growth hormone receptor is associated with better response to pegvisomant therapy in acromegaly. [2010.01]
Experience from the Argentine Pegvisomant Observational Study: preliminary data. [2010]
Eight-year follow-up of a child with a GH/prolactin-secreting adenoma: efficacy of pegvisomant therapy. [2010]
A Canadian multi-centre, open-label long-term study of Pegvisomant treatment in refractory acromegaly. [2009.12.01]
Pegvisomant: current and potential novel therapeutic applications. [2009.12]
Influence of disease control with pegvisomant on sleep apnoea and tongue volume in patients with active acromegaly. [2009.12]
Which patients with acromegaly are treated with pegvisomant? An overview of methodology and baseline data in ACROSTUDY. [2009.11]
Clinical effectiveness and cost-effectiveness of pegvisomant for the treatment of acromegaly: a systematic review and economic evaluation. [2009.10.08]
Somatostatin analog and pegvisomant combination therapy for acromegaly. [2009.10]
Pituitary tumor size in acromegaly during pegvisomant treatment: experience from MR re-evaluations of the German Pegvisomant Observational Study. [2009.07]
Successful use of weekly pegvisomant administration in patients with acromegaly. [2009.07]
Pegvisomant improves insulin sensitivity and reduces overnight free fatty acid concentrations in patients with acromegaly. [2009.07]
Long-term experience of pegvisomant therapy as a treatment for acromegaly. [2009.07]
The effect of acute application of pegvisomant alone and in combination with octreotide on endogenous GH levels during a 6-h test in patients with acromegaly on constant pegvisomant treatment. [2009.06]
Pegvisomant-induced cholestatic hepatitis with jaundice in a patient with Gilbert's syndrome. [2009.05]
Long-term treatment of acromegalic patients resistant to somatostatin analogues with the GH receptor antagonist pegvisomant: its efficacy in relation to gender and previous radiotherapy. [2009.04]
Combined treatment for acromegaly with long-acting somatostatin analogs and pegvisomant: long-term safety for up to 4.5 years (median 2.2 years) of follow-up in 86 patients. [2009.04]
Growth hormone receptor polymorphism and the effects of pegvisomant in acromegaly. [2009]
Long term experience of pegvisomant therapy as a treatment for acromegaly. [2008.11.05]
Follow-up of pituitary tumor volume in patients with acromegaly treated with pegvisomant in clinical trials. [2008.11]
Lipodystrophy in patients with acromegaly receiving pegvisomant. [2008.09]
Treatment of pituitary gigantism with the growth hormone receptor antagonist pegvisomant. [2008.08]
Long-term effects of pegvisomant in patients with acromegaly. [2008.06]
Pegvisomant-primed GH stimulation test. [2008.06]
The role of pegvisomant in the treatment of acromegaly. [2008.05]
Pegvisomant increases intra-abdominal fat in patients with acromegaly: a pilot study. [2008.04]
Long-term efficacy and safety of combined treatment of somatostatin analogs and pegvisomant in acromegaly. [2007.12]
Concomitant, specific determination of growth hormone and pegvisomant in human serum. [2007.10]
Treatment of acromegaly with pegvisomant during pregnancy: maternal and fetal effects. [2007.09]
[Pegvisomant--growth hormone receptor antagonist in the treatment of acromegaly] [2007.09]
Discovery and uses of pegvisomant: a growth hormone antagonist. [2007.07]
The impact of pegvisomant treatment on substrate metabolism and insulin sensitivity in patients with acromegaly. [2007.05]
Pegvisomant treatment in gigantism caused by a growth hormone-secreting giant pituitary adenoma. [2007.03]
Clinical pharmacodynamic effects of the growth hormone receptor antagonist pegvisomant: implications for cancer therapy. [2007.02.01]
Treatment of acromegaly with the GH receptor antagonist pegvisomant in clinical practice: safety and efficacy evaluation from the German Pegvisomant Observational Study. [2007.01]
Gender, body weight, disease activity, and previous radiotherapy influence the response to pegvisomant. [2007.01]
Experience from the German pegvisomant observational study. [2007]
Pituitary tumor enlargement in two patients with acromegaly during pegvisomant therapy. [2007]
Long-term effects of the combination of pegvisomant with somatostatin analogs (SSA) on glucose homeostasis in non-diabetic patients with active acromegaly partially resistant to SSA. [2007]
McCune-Albright syndrome and acromegaly: effects of hypothalamopituitary radiotherapy and/or pegvisomant in somatostatin analog-resistant patients. [2006.12]
IVF/ICSI in a woman with active acromegaly: successful outcome following treatment with pegvisomant. [2006.11]
Reductions of circulating matrix metalloproteinase 2 and vascular endothelial growth factor levels after treatment with pegvisomant in subjects with acromegaly. [2006.11]
An unusual somatotropin and thyreotropin secreting pituitary adenoma efficiently controlled by Octreotide and Pegvisomant. [2006.06]
Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant. [2006.06]
Efficacy of 12-month treatment with the GH receptor antagonist pegvisomant in patients with acromegaly resistant to long-term, high-dose somatostatin analog treatment: effect on IGF-I levels, tumor mass, hypertension and glucose tolerance. [2006.03]
Elevated transaminases during medical treatment of acromegaly: a review of the German pegvisomant surveillance experience and a report of a patient with histologically proven chronic mild active hepatitis. [2006.02]
Pegvisomant treatment in a 4-year-old girl with neurofibromatosis type 1. [2006]
Nanomedicines in the treatment of acromegaly: focus on pegvisomant. [2006]
Pegvisomant Treatment in a 4-Year-Old Girl with Neurofibromatosis Type 1. [2005.11.01]
Treatment of pituitary tumors: pegvisomant. [2005.10]
Markers of cell proliferation in a GH-producing adenoma of a patient treated with pegvisomant. [2005.08]
Pegvisomant therapy in pituitary gigantism: successful treatment in a 12-year-old girl. [2005.08]
Combined therapy with somatostatin analogues and weekly pegvisomant in active acromegaly. [2005.05.07]
Alternate-day administration of pegvisomant maintains normal serum insulin-like growth factor-I levels in patients with acromegaly. [2005.03]
Disease activity in acromegaly may be assessed 6 weeks after discontinuation of pegvisomant. [2005.01]
The place of pegvisomant in the acromegaly treatment algorithm. [2004.06]
Pegvisomant Pfizer/Sensus. [2004.04]
Pegvisomant: a novel pharmacotherapy for the treatment of acromegaly. [2004.03]
Pegvisomant-induced serum insulin-like growth factor-I normalization in patients with acromegaly returns elevated markers of bone turnover to normal. [2003.12]
Insulin sensitivity and glucose tolerance improve in patients with acromegaly converted from depot octreotide to pegvisomant. [2003.12]
Pegvisomant in the treatment of acromegaly. [2003.09.26]
The effect of pegvisomant-induced serum IGF-I normalization on serum leptin levels in patients with acromegaly. [2003.08]
Pegvisomant: an advance in clinical efficacy in acromegaly. [2003.04]
Clinical use of pegvisomant for the treatment of acromegaly. [2003]
Pegvisomant. Pharmacia. [2002.05]
Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist. [2001.11.24]
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