SUMMARY
SOMA® COMPOUND with CODEINE
(carisoprodol, aspirin and codeine phosphate, USP)
200 mg + aspirin 325 mg + codeine phosphate 16 mg.
INDICATIONS AND USAGE - ‘Soma’ Compound with Codeine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of pain, muscle spasm, and limited mobility associated with acute, painful musculoskeletal conditions when the additional action of codeine is desired.
|
NEWS HIGHLIGHTS
Clinical Trials Related to Soma Compound with Codeine (Carisoprodol / Aspirin / Codeine)
Prevention of Radiation Pneumonitis After Three-Dimensional Conformal Radiation Therapy (3D-CRT) in Patients With Non-Small-Cell Lung Cancer [Recruiting]
The purpose of this study is to evaluate the interest of breath holding for the prevention
of radiation pneumonitis following conformal radiation therapy.
Eligible patients will be randomly assigned in a 2-arm trial to free breathing or breath
holding during conformal radiation.
The primary objective of the study is to establish the efficacy of breath holding, compared
to free breathing, in the prevention of early pulmonary toxicity following conformal
radiation.
Several departments of radiotherapy, many pneumology units and two basic and applied
research laboratories take part in this multicentric study.
The number of patients required to demonstrate a reduction in radiation pneumonitis from 45
% to 22. 5 %, assuming an alpha risk of 5% in a two-sided test and 95% power, is 240 (120 per
arm). With a planned accrual of 7 patients per month, it is estimated that the inclusion
period should be approximately 3 years.
A Pharmacogenetic Investigation of Antipsychotics in Schizophrenia and Schizophrenia-Like Psychoses [Recruiting]
An individual's genetic make-up is known to determine their response to antipsychotic
medication. Genetic markers that determine efficacy and side effects of medication may be
identified and used to predict treatment outcome.
The study is a naturalistic study of routinely prescribed antipsychotics using outcome
measures undertaken as part of the routine clinical care of the cohort. These clinical data
are linked with genetic information obtained from DNA and RNA from blood samples undertaken
as part of the study.
No alteration is made to the subjects treatment regime or medication.
The study is a two stage investigation:
- The first stage involves the collection of a databank of clinical information and blood
samples for DNA and RNA extraction from patients treated with antipsychotic medication.
- The second stage is a molecular genetic investigation of treatment-related genetic
factors that may contribute to response prediction and predisposition to side effects.
From these genetic studies pharmacogenetic prediction tests will be validated and/or
developed.
Study to Determine if Hyperbaric Oxygen Therapy is Helpful for Treating Radiation Tissue Injuries [Recruiting]
The principle objective of this research is to more precisely determine the degree of
benefit that hyperbaric oxygen therapy affords in the treatment of late radiation tissue
injury.
The study has eight* components. Seven involve the evaluation of established radionecrosis
at varying anatomic sites (mandible, larynx, skin, bladder, rectum, colon, and gyn). The
eighth will investigate the potential of hyperbaric oxygen (HBO) therapy to prophylax
against late radiation tissue injury.
*(One of the arms, HORTIS IV - Proctitis has been closed to further patient recruitment.
This decision was based on an interim statistical analysis which generated sufficient
evidence to support closing down this arm of HORTIS.)
Trental & Vitamin E for Radiation-Induced Fibrosis [Recruiting]
This study seeks to determine if a combination of Trental and Vitamin E prevents the
development of radiation fibrosis in women treated with radiation for the definitive
management of their breast cancer.
Radiation Therapy in Treating Patients With Malignant Spinal Cord Compression Who Were Previously Treated With Radiation Therapy [Recruiting]
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Radiation therapy
may be effective in treating malignant spinal cord compression in patients who have received
previous radiation therapy to the spine.
PURPOSE: This phase II trial is studying radiation therapy in treating patients with
malignant spinal cord compression.
|
