NEWS HIGHLIGHTSMedia Articles Related to Soma (Carisoprodol)
For The First Time, Child Health Days Reach Displaced Communities In Afgoye, South Somalia
Source: Aid / Disasters News From Medical News Today [2009.11.12]
Somali children and women received a high-impact life-saving health package during the Child health Days Campaign in the Afgoye Corridor, a 30 kilometer stretch of road west of Mogadishu and the world's most densely populated settlement for the displaced. At least 46,000 children under-five and 37,000 women of child-bearing age benefited during the five-day campaign.
Scientists Successfully Reprogram Blood Cells To Correct Lysosomal Storage Disease
Source: Endocrinology News From Medical News Today [2009.11.10]
Researchers have transplanted genetically modified hematopoietic stem cells into mice so that their developing red blood cells produce a critical lysosomal enzyme preventing or reducing organ and central nervous system damage from the often-fatal genetic disorder Hurler's syndrome. The research team from Cincinnati Children's Hospital Medical Center reports its preclinical laboratory results this week in the early edition of Proceedings of the National Academy of Sciences.
Is Somatic Hypersensitivity A Predictor Of Irritable Bowel Syndrome?
Source: Irritable-Bowel Syndrome News From Medical News Today [2009.07.23]
Although visceral hypersensitivity is considered a hallmark feature of IBS, conflicting evidence exists regarding somatic hypersensitivity in this patient population. Several investigators have found no evidence for heightened somatic pain sensitivity in IBS patients. Also, others have reported similar cold presser pain tolerance in IBS patients and controls. These conflicting findings may result from differing somatic pain testing procedures.
In A Flash: New Flash CT Reduces Radiation Dose By Up To 90%
Source: MRI / PET / Ultrasound News From Medical News Today [2009.11.19]
NYU Langone Medical Center is the first hospital in the Northeast to offer one of the world's fastest and most radiation dose efficient computed tomography (CT) scanner. The Siemens SOMATOM Definition Flash can image ten times as fast as other clinical units, with an up to 90% dose reduction in radiation compared to conventional imaging.
Non-invasive Methods To Detect Schistosome-based Bladder Cancer: Is The Association Sufficient For Epidemiological Use?
Source: Urology / Nephrology News From Medical News Today [2009.11.16]
UroToday.com - Urinary schistosomiasis caused by the trematode parasite Schistosoma haematobium is endemic in most of Africa. This infection is one of the world's great neglected diseases and it is a known carcinogen. The parasite is long lived, and causes sustained inflammation in the vesicular veins where the adults live for as long a 10 or 12 years.
Published Studies Related to Soma (Carisoprodol)
Double-blind, placebo-controlled trial of carisoprodol 250-mg tablets in the treatment of acute lower-back spasm. [2008.02]
PURPOSE: The objective of this placebo-controlled trial was to determine the efficacy and safety of carisoprodol (Soma, MedPointe Pharmaceuticals, Somerset, NJ, USA), a centrally acting skeletal muscle relaxant used to treat acute, painful musculoskeletal conditions, at a dosage of 250 mg three times daily and at bedtime in patients with acute, painful muscle spasm of the lower back... CONCLUSIONS: In this study, patients with acute muscle spasm of the lower back had significantly greater and more rapid relief from starting backache, and had improved functional status, as measured by the RMDQ, during treatment with carisoprodol 250-mg tablets compared to placebo. Patients experienced clinical improvement with or without sedation.
Cognitive-behavioural therapy for patients with multiple somatoform symptoms--a randomised controlled trial in tertiary care. [2004.04]
OBJECTIVE: (a) To evaluate the effect of a cognitive-behavioural inpatient treatment and (b) to analyse the differential efficacy of an additional ("soma") group management training of somatisation... CONCLUSION: Considering the subjects' high initial impairment, the outcome results are encouraging. The specific effect on health care use highlights the socioeconomic relevance. Copyright 2004 Elsevier Inc.
Late toxicity results of the GORTEC 94-01 randomized trial comparing radiotherapy with concomitant radiochemotherapy for advanced-stage oropharynx carcinoma: comparison of LENT/SOMA, RTOG/EORTC, and NCI-CTC scoring systems. [2003.01.01]
CONCLUSION: Concomitant radiochemotherapy increased overall survival and locoregional control rates. The difference between the two treatment groups for Grade 3-4 complications was only significant for the teeth. The late toxicity assessment of a treatment may depend on the toxicity scale used. The LENT/SOMA scale seems to be the most accurate scale, but most of the score results were not concordant with those obtained with other scales. The results of this study confirm the necessity of using a common late toxicity scale in clinical trials.
Time course of adult castration-induced changes in soma size of motoneurons in the rat spinal nucleus of the bulbocavernosus. [2009.04.24]
The spinal nucleus of the bulbocavernosus (SNB) innervates striated muscles, the bulbocavernosus and levator ani (BC/LA), which control penile reflexes. Castration results in shrinkage in the size of SNB somata and dendrites, as well as BC/LA muscle mass...
The cytoarchitecture and soma-dendritic arbors of the pyramidal neurons of aged rat sensorimotor cortex: an intracellular dye injection study. [2009.01.23]
We studied the cytoarchitecture and dendritic arbors of the output neurons of the sensorimotor cortex of aged rats and found that although individual cortical layer became thinner, the overall cytoarchitecture and neuron densities remained comparable to those of young adults... These could underlie the compromise of sensorimotor functions following aging.
Clinical Trials Related to Soma (Carisoprodol)
Prevention of Radiation Pneumonitis After Three-Dimensional Conformal Radiation Therapy (3D-CRT) in Patients With Non-Small-Cell Lung Cancer [Recruiting]
The purpose of this study is to evaluate the interest of breath holding for the prevention
of radiation pneumonitis following conformal radiation therapy.
Eligible patients will be randomly assigned in a 2-arm trial to free breathing or breath
holding during conformal radiation.
The primary objective of the study is to establish the efficacy of breath holding, compared
to free breathing, in the prevention of early pulmonary toxicity following conformal
radiation.
Several departments of radiotherapy, many pneumology units and two basic and applied
research laboratories take part in this multicentric study.
The number of patients required to demonstrate a reduction in radiation pneumonitis from 45
% to 22. 5 %, assuming an alpha risk of 5% in a two-sided test and 95% power, is 240 (120 per
arm). With a planned accrual of 7 patients per month, it is estimated that the inclusion
period should be approximately 3 years.
Parotid-Sparing Intensity-Modulated Radiation Therapy Compared With Conventional Radiation Therapy in Treating Patients With Oropharyngeal or Hypopharyngeal Cancer Who Are at High Risk of Radiation-Induced Xerostomia [Active, not recruiting]
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells.
Intensity-modulated radiation therapy delivers thin beams of radiation of different strengths
directly to the tumor from many angles. This type of radiation therapy may reduce damage to
the parotid (salivary) glands, prevent xerostomia (dry mouth), and improve quality of life.
It is not yet known whether intensity-modulated radiation therapy is more effective than
conventional radiation therapy in preventing xerostomia and improving quality of life in
patients who have throat cancer.
PURPOSE: This randomized phase III trial is studying intensity-modulated radiation therapy to
see how well it works compared to conventional radiation therapy in treating patients with
oropharyngeal or hypopharyngeal cancer who are at risk of developing xerostomia caused by
radiation therapy.
Trial of Safety Nets In Hospitalized Patients [Completed]
This study compared standard hospital restraints to a newer safety net restraint system to
compare them for acceptability, tolerance, duration of restrain, length of stay in the
hospital, and satisfaction of MD, nurse, and relatives of patients.
A Pharmacogenetic Investigation of Antipsychotics in Schizophrenia and Schizophrenia-Like Psychoses [Recruiting]
An individual's genetic make-up is known to determine their response to antipsychotic
medication. Genetic markers that determine efficacy and side effects of medication may be
identified and used to predict treatment outcome.
The study is a naturalistic study of routinely prescribed antipsychotics using outcome
measures undertaken as part of the routine clinical care of the cohort. These clinical data
are linked with genetic information obtained from DNA and RNA from blood samples undertaken
as part of the study.
No alteration is made to the subjects treatment regime or medication.
The study is a two stage investigation:
- The first stage involves the collection of a databank of clinical information and blood
samples for DNA and RNA extraction from patients treated with antipsychotic medication.
- The second stage is a molecular genetic investigation of treatment-related genetic
factors that may contribute to response prediction and predisposition to side effects.
From these genetic studies pharmacogenetic prediction tests will be validated and/or
developed.
Study to Determine if Hyperbaric Oxygen Therapy is Helpful for Treating Radiation Tissue Injuries [Recruiting]
The principle objective of this research is to more precisely determine the degree of
benefit that hyperbaric oxygen therapy affords in the treatment of late radiation tissue
injury.
The study has eight* components. Seven involve the evaluation of established radionecrosis
at varying anatomic sites (mandible, larynx, skin, bladder, rectum, colon, and gyn). The
eighth will investigate the potential of hyperbaric oxygen (HBO) therapy to prophylax
against late radiation tissue injury.
*(One of the arms, HORTIS IV - Proctitis has been closed to further patient recruitment.
This decision was based on an interim statistical analysis which generated sufficient
evidence to support closing down this arm of HORTIS.)
|
