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Solodyn (Minocycline Hydrochloride) - Summary

 
 



SOLODYN SUMMARY

Minocycline hydrochloride, a semi synthetic derivative of tetracycline, is a bacteriostatic antimicrobial agent.

SOLODYN™ is indicated to treat only inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 12 years of age and older. SOLODYN™ did not demonstrate any effect on non-inflammatory lesions. Safety of SOLODYN™ has not been established beyond 12 weeks of use.

This formulation of minocycline has not been evaluated in the treatment of infections.

To reduce the development of drug-resistant bacteria as well as to maintain the effectiveness of other antibacterial drugs, SOLODYN™ should be used only as indicated.


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NEWS HIGHLIGHTS

Published Studies Related to Solodyn (Minocycline)

Effect of minocycline on lumbar radicular neuropathic pain: a randomized, placebo-controlled, double-blind clinical trial with amitriptyline as a comparator. [2015]
the treatment of neuropathic pain... CONCLUSIONS: Although both groups differed from placebo, their effect size was

Effect of Minocycline on Lumbar Radicular Neuropathic Pain: A Randomized, Placebo-controlled, Double-blind Clinical Trial with Amitriptyline as a Comparator. [2014]
the treatment of neuropathic pain... CONCLUSIONS:: Although both groups differed from placebo, their effect size was

Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. [2014]
Elevated cerebrospinal fluid (CSF) levels of markers of oxidative stress, neuronal injury, and inflammation and decreased neurotransmitter levels have been reported in HIV-associated neurocognitive disorders (HAND). Minocycline may have a neuroprotective effect by inhibiting inducible nitric oxide synthase, which produces nitric oxide, a compound that induces oxygen free radical production...

Minocycline supplementation for treatment of negative symptoms in early-phase schizophrenia: a double blind, randomized, controlled trial. [2014]
patients with schizophrenia... CONCLUSIONS: The addition of minocycline to atypical antipsychotic drugs in early

Adjuvant therapy with minocycline for schizophrenia (The MINOS Trial): study protocol for a double-blind randomized placebo-controlled trial. [2013]
BACKGROUND: Schizophrenia is understood to be a heterogeneous brain condition with overlapping symptom dimensions. The negative symptom dimension, with its protean cognitive manifestations, responds poorly to treatment, which can be a particular challenge in countries where clozapine therapy is not available.

more studies >>

Clinical Trials Related to Solodyn (Minocycline)

Minocycline Study in Non Small Cell Lung Cancer (NSCLC) Patients for Chemoradiation Therapy [Active, not recruiting]
The goal of this clinical research study is to learn if minocycline can reduce the side effects reported by patients with NSCLC who are receiving chemoradiation therapy. In this study, minocycline will be compared to a placebo. Minocycline is an antibiotic that may help to reduce side effects of chemoradiation therapy. A placebo is not a drug. It looks like the study drug but is not designed to treat any disease or illness. It is designed to be compared with a study drug to learn if the study drug has any real effect.

Minocycline for Postsurgical Symptom Reduction in Head and Neck Cancer [Recruiting]
The goal of this clinical research study is to learn if Minocin (minocycline) can reduce certain side effects of surgery in patients with head and neck cancer (such as pain, fatigue, and disturbed sleep). In this study, minocycline will be compared to a placebo. A placebo is not a drug. It looks like the study drug, but it is not designed to treat any disease or illness. It is designed to be compared with a study drug to learn if the study drug has any real effect.

A Phase II Study of Minocycline and Armodafinil for Reducing the Symptom Burden Produced by Chemoradiation Treatment for Esophageal Cancer [Active, not recruiting]
The goal of this clinical research study is to compare armodafinil and minocycline when given alone or in combination to learn which is better for controlling side effects of chemoradiation treatment for esophageal cancer (such as fatigue, pain, disturbed sleep, lack of appetite, and drowsiness). Armodafinil is designed to prevent excessive sleepiness. Minocycline is an antibiotic, which may help to reduce multiple symptoms. In this study, you may receive a placebo. A placebo is not a drug. It looks like the study drug but is not designed to treat any disease or illness. It is designed to be compared with a study drug to learn if the study drug has any real effect.

A Study for Reducing Symptom Burden Produced by Chemoradiation Treatment for Non Small Cell Lung Cancer by Minocycline and Armodafinil [Active, not recruiting]
The goal of this clinical research study is to compare armodafinil and minocycline when given alone or in combination to learn which is better for controlling symptoms, such as the side effects of chemoradiation, when given to treat lung cancer.

Phase II Study of Minocycline for Reducing Symptom Burden in Colorectal Patients [Recruiting]
The goal of this clinical research study is to learn if minocycline can reduce numbness, pain, and/or loss of motor function in patients with colorectal cancer. In this study, minocycline will be compared to a placebo. The study doctor can explain how the study drug is designed to work. A placebo is not a drug. It looks like the study drug, but it is not designed to treat any disease or illness. It is designed to be compared with a study drug to learn if the study drug has any real effect.

more trials >>

Reports of Suspected Solodyn (Minocycline) Side Effects

Headache (5)Confusional State (4)Pruritus (3)Extrasystoles (3)Dizziness (3)Drug Dispensing Error (3)Blood Glucose Increased (3)Dyspnoea (3)Drug Hypersensitivity (3)Hypersensitivity (2)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 6 ratings/reviews, Solodyn has an overall score of 4. The effectiveness score is 6.67 and the side effect score is 4.33. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Solodyn review by 28 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   Acne
Dosage & duration:   90mg taken once a day for the period of 30 days
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   Solodyn virtually eliminated any acne I had, both on my face and body. It took about a month to see dramatic results, but some results were visible within a few days of starting the medication.
Side effects:   I didn't experience any side effects until about four weeks into treatment, at which time I began breaking out in very mild hives. They were so mild, in fact, that I originally thought they may have been caused by a lotion or cosmetic that had gotten on my skin, or maybe by something I had eaten. The hives would come and go throughout the day, appearing very sparsely on my face, neck, and/or hands. A few days passed, and I realized that they must have been caused by the drug, so I stopped taking it and the hives went away after a day or so. I want to stress that these hives were very mild. I have had allergic reactions to drugs in the past (which may have made be more susceptible this time) and every previous experience I've had with drug-related hives has been much, much worse and possibly life-threatening if not treated. Perhaps that would have been the case with these as well if I had continued taking the drug, but they didn't seem to be particularly alarming, just mildly annoying.
Comments:   I took one pill every morning at the same time each day.

 

Solodyn review by 38 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   acne
Dosage & duration:   45 mg taken once a day for the period of 5 weeks
Other conditions:   None
Other drugs taken:   Yaz
  
Reported Results
Benefits:   While on the drug I did not have any large, red acne lesions.
Side effects:   Lupus-like symptoms that were very severe: light sensitivity extreme fatigue severe joint point iritis (inflammation of the iris of the eye) knee, wrist and finger pain that continues 4 months after stopping the drug iritis flared again 4 months after stopping the drug
Comments:   After I turned 38 my skin changed. It became much oilier and I started having large acne lesions again around my chin. This was especially true before a period or when I was under stress at work. I decided to see a dermatologist as I was sick of the acne. I started Yaz which was alright, as well as Retin-A. This didn't seem to address the larger lesions so my dr. prescribed Solodyn. Looking back now, I think the side-effect started in the first couple weeks, I just didn't identify them as related to the drug. I thought I was suffering from carpal tunnel at work and could explain why my knees hurt so much. I was just about to go to an orthopod when I decided to investigate the Solodyn more. I read about the joint pain and Lupus-like symptoms, stopped the drug immediately and called my dr. to get in and see her. She did some bloodwork and I had a positive ANA blood result (mid-positive, not low). This is one indicator of lupus. My dermatologist was adamant that the symptoms would go away now. I called the office again a week later as I was still having strong side effects and was pretty worried. I got a phone call back that basically said "hello, hypochondriac, you do not have lupus." Then my eye pain started and my eye turned totally red. I went to my GP who referred me to an opthalmologist who diagnosed iritis and I started 7 weeks of drops. She also referred me to a rheumatologist who ran a number of tests and told me she's seen minocycline drugs do this to people a lot and she would never take one or have her children take one - great. That's my saga. Now dealing with another iritis flair up and a lot of pain in my left knee, 4 months after stopping the drug. Please don't take this drug!!!

 

Solodyn review by 38 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   acne
Dosage & duration:   65 mg taken one per day for the period of 2 weeks
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   I started this medicine to help my acne, but after a couple of weeks there was no improvement at all. In fact, my skin was worse. I've taken other antibiotics in the past and they were much more effective at clearing up my skin. So I stopped taking the Solodyn.
Side effects:   I haven't taken Solodyn now for a week and I am experiencing very itchy skin, achy joints, and fatigue. The itchy skin is mostly on my scalp and neck. Today I had itchy hives on my leg as well. The joint pain is mostly in my right hand and wrist. It hurts to make a fist and then open my hand back up. I've had allergic reactions to other meds before, but they would stop when I stopped the medicine. For some reason, these nasty side effects are lingering.
Comments:   none

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Page last updated: 2015-08-10

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