Slow-K (Potassium Chloride) - Summary

SLOW-K SUMMARY

Slow-K^®

Slow-K, potassium chloride extended-release tablets USP, is a sugar-coated (not enteric-coated) tablet for oral administration, containing 600 mg of potassium chloride (equivalent to 8 mEq) in a wax matrix. This formulation is intended to provide an extended-release of potassium from the matrix to minimize the likelihood of producing high, localized concentrations of potassium within the gastrointestinal tract. Slow-K is an electrolyte replenisher.

BECAUSE OF REPORTS OF INTESTINAL AND GASTRIC ULCERATION AND BLEEDING WITH EXTENDED-RELEASE POTASSIUM CHLORIDE PREPARATIONS, THESE DRUGS SHOULD BE RESERVED FOR THOSE PATIENTS WHO CANNOT TOLERATE OR REFUSE TO TAKE LIQUID OR EFFERVESCENT POTASSIUM PREPARATIONS OR FOR PATIENTS IN WHOM THERE IS A PROBLEM OF COMPLIANCE WITH THESE PREPARATIONS.

1. For therapeutic use in patients with hypokalemia, with or without metabolic alkalosis; in digitalis intoxication; and in patients with hypokalemic familial periodic paralysis. If hypokalemia is the result of diuretic therapy, consideration should be given to the use of a lower dose of diuretic, which may be sufficient without leading to hypokalemia.
   
2. For the prevention of hypokalemia in patients who would be at particular risk if hypokalemia were to develop, e.g., digitalized patients or patients with significant cardiac arrhythmias.

The use of potassium salts in patients receiving diuretics for uncomplicated essential hypertension is often unnecessary when such patients have a normal dietary pattern and when low doses of the diuretic are used. Serum potassium should be checked periodically, however, and if hypokalemia occurs, dietary supplementation with potassium-containing foods may be adequate to control milder cases. In more severe cases, and if dose adjustment of the diuretic is ineffective or unwarranted, supplementation with potassium salts may be indicated.

See all Slow-K indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Slow-K (Potassium)

Hyperkalemia (High Blood Potassium)
Source: MedicineNet Addison Disease Specialty [2016.08.16]
Title: Hyperkalemia (High Blood Potassium)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 8/16/2016 12:00:00 AM

Low Potassium (Hypokalemia)
Source: MedicineNet Hyperkalemia Specialty [2015.11.03]
Title: Low Potassium (Hypokalemia)
Category: Diseases and Conditions
Created: 3/12/2008 12:00:00 AM
Last Editorial Review: 11/3/2015 12:00:00 AM

Health Tip: Potassium is an Essential Mineral
Source: MedicineNet Hyperkalemia Specialty [2015.10.29]
Title: Health Tip: Potassium is an Essential Mineral
Category: Health News
Created: 10/29/2015 12:00:00 AM
Last Editorial Review: 10/29/2015 12:00:00 AM

more news >>

Published Studies Related to Slow-K (Potassium)

Myocardial protection by glucose-insulin-potassium in acute coronary syndrome patients undergoing urgent multivessel off-pump coronary artery bypass surgery. [2013]
coronary artery bypass (OPCAB) surgery... CONCLUSIONS: GIK administration in ACS patients undergoing urgent multivessel

Myocardial protection by glucose-insulin-potassium in acute coronary syndrome patients undergoing urgent multivessel off-pump coronary artery bypass surgery. [2013]
coronary artery bypass (OPCAB) surgery... CONCLUSIONS: GIK administration in ACS patients undergoing urgent multivessel

Efficacy of a commercial dentifrice containing 2% strontium chloride and 5% potassium nitrate for dentin hypersensitivity: a 3-day clinical study in adults in China. [2012]
silica base without any active ingredient (control dentifrice)... CONCLUSION: In these patients with DH in China, the dentifrice containing 2%

Blood pressure lowering efficacy of potassium-sparing diuretics (that block the epithelial sodium channel) for primary hypertension. [2012]
CONCLUSIONS: ENaC blockers do not have a statistically or clinically

Comparison of risk factor reduction and tolerability of a full-dose polypill (with potassium) versus low-dose polypill (polycap) in individuals at high risk of cardiovascular diseases: the Second Indian Polycap Study (TIPS-2) investigators. [2012]
CONCLUSIONS: The full-dose polycap (plus K(+) supplementation) reduces BP and

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Clinical Trials Related to Slow-K (Potassium)

Vitrification and Slow Freezing for Cryopreservation of Blastocyst [Recruiting]
Improvement in the treatment of infertility by Assisted Reproductive Techniques (ART) allows single embryo transfer to be applied without compromising pregnancy rates after the first in vitro fertilization (IVF) or Intra Cytoplasmic Sperm Injection (ICSI) attempt in women less than 36 years old with good embryo quality. The policy of transferring more than one embryo after IVF or ICSI has been the main reason for the numerous twin or triple pregnancies reported in Europe and United States over the past 15 years. These multiple pregnancies are the main disadvantage of ART because of their negative impact on obstetrical, neonatal and economic outcome. In the past, embryos were replaced in the uterus on either Day-2 or 3 of development at the cleavage stage. With the development of physiologically-based sequential culture media, it has also been suggested that extending embryo culture to Day-5 in order to transfer the embryo at the blastocyst stage would enhance the likelihood of pregnancy. Nevertheless, it has been observed higher pregnancy rate after the transfer of fresh blastocyst but not after the transfer of thawed blastocyst frozen by slow freezing procedure. However a recent embryo freezing technique (vitrification) seems to show significant higher pregnancy rates when blastocyst are frozen by this method. To our knowledge, no publications have reported the outcome of single embryo transfer at blastocyst stage by a prospective randomized and comparative study including the results of fresh and frozen/thawed blastocyst by these two methods (slow freezing vs. vitrification) in case of single embryo transfer . Therefore, the aim of our study is to analyze whether extended culture of Day-2 top embryos to blastocyst-stage may improve the cumulative delivery rate in an in vitro fertilization program with Single Embryo Transfer policy in a prospective and randomized study integrating the transfer of fresh and frozen/thawed embryos using a slow freezing versus vitrification procedure.

Oocyte Cryopreservation by Slow Freezing and Vitrification [Terminated]
This study seeks to evaluate whether the vitrification technique, as compared to the more traditional slow-cooling technique, leads to higher rates of successful thawing, fertilization, implantation and delivery.

the Pops-titration Versus the Slow-coagulation Cyclophotocoagulation in Treatment of Refractory Glaucoma [Recruiting]

- Transcleral cyclophotocoagulation (TSCPC) has long been used as refractory glaucoma

management and is very easy to learn and easy to perform.

- Recent advances in laser technology; the role of TSCPC is being expanded because it has

benefits of noninvasive glaucoma procedure.

- The titration (pops), the fixed high-energy, and the fixed-low energy

(slow-coagulation) are three energy delivery techniques.

- The present study would report on the outcome (efficacy and safety) of the

slow-coagulation versus the titration method in treatment of refractory glaucoma with dark iris.

- The results would provide reliable evidences to supplement clinical judgment when

making a decision in favor of each treatment method for glaucoma patients.

Pharmacodynamic Trial, of Slow Release ASA, in Platelet Functionalism, a Long Term Treatment Period [Completed]
Evaluation of the pharmacodynamic profile (antiaggregant profile, balance of prostanoids and nitric oxid) of a ASA-SR (slow-release)formulation in comparison with a ASA NR (normal release), 150 mg, during 12 months of treatment.

Randomized Controlled Trial Comparing Slow-freezing to Vitrification of Oocytes [Terminated]
Preservation of fertility is limited. Current methods include embryo cryopreservation and while still experimental, ovarian cryopreservation. In single women who are at risk for infertility secondary to cancer or couples who have ethical reasons to avoid embryo cryopreservation, oocyte cryopreservation is an alternative Purpose of study is to compare slow freeze to vitrification of human oocytes. Successful cryopreservation and subsequent thawing programs are characterized by avoiding ice crystal formation. Vitrification, newer alternative to slow freeze method, process by which water is prevented from forming ice. Our hypothesis is that higher survival rate per oocyte is to be expected in the vitrification group.

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Reports of Suspected Slow-K (Potassium) Side Effects

Asthma (12),  Cerebral Infarction (10),  Hyperkalaemia (9),  Ventricular Fibrillation (6),  Liver Disorder (5),  Drug Ineffective (4),  Decreased Appetite (4),  Cardio-Respiratory Arrest (3),  Diarrhoea (3),  Blood Pressure Decreased (3), more >>