Slow-K, potassium chloride extended-release tablets USP, is a sugar-coated (not enteric-coated) tablet for oral administration, containing 600 mg of potassium chloride (equivalent to 8 mEq) in a wax matrix. This formulation is intended to provide an extended-release of potassium from the matrix to minimize the likelihood of producing high, localized concentrations of potassium within the gastrointestinal tract. Slow-K is an electrolyte replenisher.
BECAUSE OF REPORTS OF INTESTINAL AND GASTRIC ULCERATION AND BLEEDING WITH EXTENDED-RELEASE POTASSIUM CHLORIDE PREPARATIONS, THESE DRUGS SHOULD BE RESERVED FOR THOSE PATIENTS WHO CANNOT TOLERATE OR REFUSE TO TAKE LIQUID OR EFFERVESCENT POTASSIUM PREPARATIONS OR FOR PATIENTS IN WHOM THERE IS A PROBLEM OF COMPLIANCE WITH THESE PREPARATIONS.
- For therapeutic use in patients with hypokalemia, with or without metabolic alkalosis; in digitalis intoxication; and in patients with hypokalemic familial periodic paralysis. If hypokalemia is the result of diuretic therapy, consideration should be given to the use of a lower dose of diuretic, which may be sufficient without leading to hypokalemia.
- For the prevention of hypokalemia in patients who would be at particular risk if hypokalemia were to develop, e.g., digitalized patients or patients with significant cardiac arrhythmias.
The use of potassium salts in patients receiving diuretics for uncomplicated essential hypertension is often unnecessary when such patients have a normal dietary pattern and when low doses of the diuretic are used. Serum potassium should be checked periodically, however, and if hypokalemia occurs, dietary supplementation with potassium-containing foods may be adequate to control milder cases. In more severe cases, and if dose adjustment of the diuretic is ineffective or unwarranted, supplementation with potassium salts may be indicated.
Media Articles Related to Slow-K (Potassium)
Discovery of new operating principle of potassium channels
Source: Epilepsy News From Medical News Today [2014.01.30]
Neurons transmit information with the help of special channels that allow the passage of potassium ions. Defective potassium channels play a role in epilepsy and depression. The scientists working with Prof. Henning Stahlberg at the Biozentrum of the University of Basel have now identified the complete 3D structure of a particular potassium channel, a HCN channel.
Hyperkalemia (High Blood Potassium)
Source: MedicineNet Addison Disease Specialty [2013.12.03]
Title: Hyperkalemia (High Blood Potassium)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 12/3/2013 12:00:00 AM
Low Potassium (Hypokalemia)
Source: MedicineNet Hyperkalemia Specialty [2012.03.19]
Title: Low Potassium (Hypokalemia)
Category: Diseases and Conditions
Created: 3/12/2008 12:00:00 AM
Last Editorial Review: 3/19/2012 12:00:00 AM
Are You Getting Enough Potassium?
Source: MedicineNet Laxatives For Constipation Specialty [2010.09.22]
Title: Are You Getting Enough Potassium?
Category: Doctor's & Expert's views on Symptoms
Created: 5/5/2011 6:21:00 PM
Last Editorial Review: 9/22/2010 6:21:45 PM
After a decade of debate, a clear picture of a controversial protein that helps regulate heart contractions
Source: Health News from Medical News Today [2014.03.07]
Brandeis University researchers have unlocked a controversial structure in heart cells responsible for regulating heart contractions.For years, scientists have debated how many KCNE1 proteins are required to build a potassium ion channel, theorizing anywhere between one and 14. Now, Brandeis University researchers found that these channels are built with two E1s. Understanding the construction of this channel is key to understanding life-threatening heart conditions, such as arrhythmias, and developing drugs to threat those conditions.
Published Studies Related to Slow-K (Potassium)
Myocardial protection by glucose-insulin-potassium in acute coronary syndrome
patients undergoing urgent multivessel off-pump coronary artery bypass surgery. 
coronary artery bypass (OPCAB) surgery... CONCLUSIONS: GIK administration in ACS patients undergoing urgent multivessel
Efficacy of a commercial dentifrice containing 2% strontium chloride and 5%
potassium nitrate for dentin hypersensitivity: a 3-day clinical study in adults
in China. 
silica base without any active ingredient (control dentifrice)... CONCLUSION: In these patients with DH in China, the dentifrice containing 2%
Blood pressure lowering efficacy of potassium-sparing diuretics (that block the
epithelial sodium channel) for primary hypertension. 
CONCLUSIONS: ENaC blockers do not have a statistically or clinically
Comparison of risk factor reduction and tolerability of a full-dose polypill
(with potassium) versus low-dose polypill (polycap) in individuals at high risk
of cardiovascular diseases: the Second Indian Polycap Study (TIPS-2)
CONCLUSIONS: The full-dose polycap (plus K(+) supplementation) reduces BP and
Comparison of the clinical efficacy of a new dentifrice containing 8.0% arginine,
calcium carbonate, and 1000 ppm fluoride to a commercially available sensitive
toothpaste containing 2% potassium ion on dentin hypersensitivity: a randomized
clinical trial. 
period... CONCLUSION: The use ofa new dentifrice containing 8.0% arginine, calcium
Clinical Trials Related to Slow-K (Potassium)
the Pops-titration Versus the Slow-coagulation Cyclophotocoagulation in Treatment of Refractory Glaucoma [Not yet recruiting]
- Transcleral cyclophotocoagulation (TSCPC) has long been used as refractory glaucoma
management and is very easy to learn and easy to perform.
- Recent advances in laser technology; the role of TSCPC is being expanded because it has
benefits of noninvasive glaucoma procedure.
- The titration (pops), the fixed high-energy, and the fixed-low energy
(slow-coagulation) are three energy delivery techniques.
- The present study would report on the outcome (efficacy and safety) of the
slow-coagulation versus the titration method in treatment of refractory glaucoma with
- The results would provide reliable evidences to supplement clinical judgment when
making a decision in favor of each treatment method for glaucoma patients.
Pharmacodynamic Trial, of Slow Release ASA, in Platelet Functionalism, a Long Term Treatment Period [Completed]
Evaluation of the pharmacodynamic profile (antiaggregant profile, balance of prostanoids and
nitric oxid) of a ASA-SR (slow-release)formulation in comparison with a ASA NR (normal
release), 150 mg, during 12 months of treatment.
Vitrification Versus Slow Cooling of Human Cleavage Stage Embryos [Recruiting]
Human embryos can be preserved for later transfers by freezing. Traditionally the slow
cooling method has been used. About 70% of the embryos remain fully intact after thawing.
However, the remaining 30% of the embryos become (partially) damaged, and this freezing
damage reduces their chance to implant. Recently an ultra rapid freezing method, called
vitrification has been developed. During vitrification no damaging ice crystals are formed
and the embryo freezes in a glass like state.
It appears that the freezing damage is reduced when embryos are vitrified. Observational
studies in humans indicate that embryos are successfully preserved by vitrification, as
indicated by promising pregnancy rates following thawing. However, the effectiveness of
vitrification in relation to slow cooling with respect to pregnancy rates has so far not
been evaluated by a randomised, controlled trial. The aim of this study is to investigate
whether vitrification significantly improves embryo survival and ongoing pregnancy rates
when compared to embryos frozen by slow cooling.
Short Term Hemodynamic Effects of Controlled Slow Breathing With Biofeedback in Patients With Heart Failure [Recruiting]
Heart failure is associated with faster breathing, which has a negative impact on the
functioning of the heart. This leads to fatigue, shortness of breath, and exercise
intolerance. It has been shown that when slow breathing technique was taught to patients
with heart failure, they had a reduction in their sensation of shortness of breath and an
improvement in their exercise performance.
The study will compare the short-term effects of controlled slow breathing with biofeedback
in normal healthy subjects, acute heart failure, and chronic stable heart failure. The
purpose is to see if there is any change in the objective measurements of heart function
while breathing at normal rates compared to a controlled slower rate.
Randomized Controlled Trial Comparing Slow-Freezing to Vitrification of Oocytes [Recruiting]
Preservation of fertility is limited. Current methods include embryo cryopreservation and
while still experimental, ovarian cryopreservation. In single women who are at risk for
infertility secondary to cancer or couples who have ethical reasons to avoid embryo
cryopreservation, oocyte cryopreservation is an alternative Purpose of study is to compare
slow freeze to vitrification of human oocytes. Successful cryopreservation and subsequent
thawing programs are characterized by avoiding ice crystal formation. Vitrification, newer
alternative to slow freeze method, process by which water is prevented from forming ice.
Our hypothesis is that higher survival rate per oocyte is to be expected in the
Reports of Suspected Slow-K (Potassium) Side Effects
Cerebral Infarction (10),
Ventricular Fibrillation (6),
Liver Disorder (5),
Drug Ineffective (4),
Decreased Appetite (4),
Cardio-Respiratory Arrest (3),
Blood Pressure Decreased (3), more >>