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Slow-K (Potassium Chloride) - Summary




Slow-K, potassium chloride extended-release tablets USP, is a sugar-coated (not enteric-coated) tablet for oral administration, containing 600 mg of potassium chloride (equivalent to 8 mEq) in a wax matrix. This formulation is intended to provide an extended-release of potassium from the matrix to minimize the likelihood of producing high, localized concentrations of potassium within the gastrointestinal tract. Slow-K is an electrolyte replenisher.


  1. For therapeutic use in patients with hypokalemia, with or without metabolic alkalosis; in digitalis intoxication; and in patients with hypokalemic familial periodic paralysis. If hypokalemia is the result of diuretic therapy, consideration should be given to the use of a lower dose of diuretic, which may be sufficient without leading to hypokalemia.
  2. For the prevention of hypokalemia in patients who would be at particular risk if hypokalemia were to develop, e.g., digitalized patients or patients with significant cardiac arrhythmias.

The use of potassium salts in patients receiving diuretics for uncomplicated essential hypertension is often unnecessary when such patients have a normal dietary pattern and when low doses of the diuretic are used. Serum potassium should be checked periodically, however, and if hypokalemia occurs, dietary supplementation with potassium-containing foods may be adequate to control milder cases. In more severe cases, and if dose adjustment of the diuretic is ineffective or unwarranted, supplementation with potassium salts may be indicated.

See all Slow-K indications & dosage >>


Media Articles Related to Slow-K (Potassium)

Potassium additives may make low-sodium meats unsafe for patients with kidney disease
Source: Nutrition / Diet News From Medical News Today [2014.11.19]
Potassium additives are frequently added to sodium-reduced meat products in amounts that may be dangerous for patients with kidney disease, according to a study presented at ASN Kidney Week 2014 at...

Drug helps lower high potassium levels associated with potentially lethal cardiac arrhythmias
Source: Urology / Nephrology News From Medical News Today [2014.11.18]
Mikhail Kosiborod, M.D., of Saint Luke's Mid America Heart Institute, Kansas City, and colleagues evaluated the efficacy and safety of the drug zirconium cyclosilicate in patients with hyperkalemia...

Low Potassium (Hypokalemia)
Source: MedicineNet Dehydration Specialty [2014.09.02]
Title: Low Potassium (Hypokalemia)
Category: Diseases and Conditions
Created: 3/12/2008 12:00:00 AM
Last Editorial Review: 9/2/2014 12:00:00 AM

Potassium Supplements May Help Some Heart Failure Patients
Source: MedicineNet furosemide Specialty [2014.07.17]
Title: Potassium Supplements May Help Some Heart Failure Patients
Category: Health News
Created: 7/16/2014 2:35:00 PM
Last Editorial Review: 7/17/2014 12:00:00 AM

Scientists discover new gene for devastating form of epilepsy
Source: Epilepsy News From Medical News Today [2014.11.18]
Scientists have discovered a single mutation in a potassium ion channel gene underlies many unsolved cases of the devastating disorder progressive myoclonus epilepsy.

more news >>

Published Studies Related to Slow-K (Potassium)

Myocardial protection by glucose-insulin-potassium in acute coronary syndrome patients undergoing urgent multivessel off-pump coronary artery bypass surgery. [2013]
coronary artery bypass (OPCAB) surgery... CONCLUSIONS: GIK administration in ACS patients undergoing urgent multivessel

Efficacy of a commercial dentifrice containing 2% strontium chloride and 5% potassium nitrate for dentin hypersensitivity: a 3-day clinical study in adults in China. [2012]
silica base without any active ingredient (control dentifrice)... CONCLUSION: In these patients with DH in China, the dentifrice containing 2%

Blood pressure lowering efficacy of potassium-sparing diuretics (that block the epithelial sodium channel) for primary hypertension. [2012]
CONCLUSIONS: ENaC blockers do not have a statistically or clinically

Comparison of risk factor reduction and tolerability of a full-dose polypill (with potassium) versus low-dose polypill (polycap) in individuals at high risk of cardiovascular diseases: the Second Indian Polycap Study (TIPS-2) investigators. [2012]
CONCLUSIONS: The full-dose polycap (plus K(+) supplementation) reduces BP and

Comparison of the clinical efficacy of a new dentifrice containing 8.0% arginine, calcium carbonate, and 1000 ppm fluoride to a commercially available sensitive toothpaste containing 2% potassium ion on dentin hypersensitivity: a randomized clinical trial. [2012]
period... CONCLUSION: The use ofa new dentifrice containing 8.0% arginine, calcium

more studies >>

Clinical Trials Related to Slow-K (Potassium)

the Pops-titration Versus the Slow-coagulation Cyclophotocoagulation in Treatment of Refractory Glaucoma [Not yet recruiting]

- Transcleral cyclophotocoagulation (TSCPC) has long been used as refractory glaucoma

management and is very easy to learn and easy to perform.

- Recent advances in laser technology; the role of TSCPC is being expanded because it has

benefits of noninvasive glaucoma procedure.

- The titration (pops), the fixed high-energy, and the fixed-low energy

(slow-coagulation) are three energy delivery techniques.

- The present study would report on the outcome (efficacy and safety) of the

slow-coagulation versus the titration method in treatment of refractory glaucoma with dark iris.

- The results would provide reliable evidences to supplement clinical judgment when

making a decision in favor of each treatment method for glaucoma patients.

Pharmacodynamic Trial, of Slow Release ASA, in Platelet Functionalism, a Long Term Treatment Period [Completed]
Evaluation of the pharmacodynamic profile (antiaggregant profile, balance of prostanoids and nitric oxid) of a ASA-SR (slow-release)formulation in comparison with a ASA NR (normal release), 150 mg, during 12 months of treatment.

Vitrification Versus Slow Cooling of Human Cleavage Stage Embryos [Recruiting]
Human embryos can be preserved for later transfers by freezing. Traditionally the slow cooling method has been used. About 70% of the embryos remain fully intact after thawing. However, the remaining 30% of the embryos become (partially) damaged, and this freezing damage reduces their chance to implant. Recently an ultra rapid freezing method, called vitrification has been developed. During vitrification no damaging ice crystals are formed and the embryo freezes in a glass like state.

It appears that the freezing damage is reduced when embryos are vitrified. Observational studies in humans indicate that embryos are successfully preserved by vitrification, as indicated by promising pregnancy rates following thawing. However, the effectiveness of vitrification in relation to slow cooling with respect to pregnancy rates has so far not been evaluated by a randomised, controlled trial. The aim of this study is to investigate whether vitrification significantly improves embryo survival and ongoing pregnancy rates when compared to embryos frozen by slow cooling.

Short Term Hemodynamic Effects of Controlled Slow Breathing With Biofeedback in Patients With Heart Failure [Recruiting]
Heart failure is associated with faster breathing, which has a negative impact on the functioning of the heart. This leads to fatigue, shortness of breath, and exercise intolerance. It has been shown that when slow breathing technique was taught to patients with heart failure, they had a reduction in their sensation of shortness of breath and an improvement in their exercise performance.

The study will compare the short-term effects of controlled slow breathing with biofeedback in normal healthy subjects, acute heart failure, and chronic stable heart failure. The purpose is to see if there is any change in the objective measurements of heart function while breathing at normal rates compared to a controlled slower rate.

Randomized Controlled Trial Comparing Slow-Freezing to Vitrification of Oocytes [Recruiting]
Preservation of fertility is limited. Current methods include embryo cryopreservation and while still experimental, ovarian cryopreservation. In single women who are at risk for infertility secondary to cancer or couples who have ethical reasons to avoid embryo cryopreservation, oocyte cryopreservation is an alternative Purpose of study is to compare slow freeze to vitrification of human oocytes. Successful cryopreservation and subsequent thawing programs are characterized by avoiding ice crystal formation. Vitrification, newer alternative to slow freeze method, process by which water is prevented from forming ice.

Our hypothesis is that higher survival rate per oocyte is to be expected in the vitrification group.

more trials >>

Reports of Suspected Slow-K (Potassium) Side Effects

Asthma (12)Cerebral Infarction (10)Hyperkalaemia (9)Ventricular Fibrillation (6)Liver Disorder (5)Drug Ineffective (4)Decreased Appetite (4)Cardio-Respiratory Arrest (3)Diarrhoea (3)Blood Pressure Decreased (3)more >>

Page last updated: 2014-11-19

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