SKELAXIN SUMMARY
SKELAXIN®
(Metaxalone) Tablets
SKELAXIN (metaxalone) is available as a 400 mg round, pale rose tablet and an 800 mg oval, pink scored tablet.
SKELAXIN (metaxalone) is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Metaxalone does not directly relax tense skeletal muscles in man.
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NEWS HIGHLIGHTSMedia Articles Related to Skelaxin (Metaxalone)
Muscle Spasms
Source: MedicineNet Amyotrophic Lateral Sclerosis Specialty [2009.06.17]
Title: Muscle Spasms
Category: Diseases and Conditions
Created: 6/16/2009
Last Editorial Review: 6/17/2009
Published Studies Related to Skelaxin (Metaxalone)
A fatality involving metaxalone. [2005.05.10]
A case is presented of a 54-year-old white female found dead in a secured apartment... The medical examiner ruled that the cause of death was metaxalone and gabapentin intoxication and the manner of death was suicide.
Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone. [2004.09]
BACKGROUND: Low back pain is a leading reason for primary care visits. Many treatment options are available, but some lack scientific support. OBJECTIVE: The aim of this review was to discuss the etiology of low back pain and the relative risks and benefits of muscle relaxants commonly prescribed for the management of back pain... CONCLUSIONS: Analgesic pain management for low back pain due to muscle spasm may be combined with a muscle relaxant. Cyclobenzaprine hydrochloride has the most recent and largest clinical trials demonstrating its benefit, but carisoprodol and metaxalone also appear to be effective. However, carisoprodol's usefulness is mitigated by its potential for abuse.
Metaxalone (Skelaxin)-related death. [2004.09]
The case history and toxicological findings of a fatal multi-drug overdose involving metaxalone (Skelaxin) are presented. Gas-liquid chromatography with flame-ionization detection and gas chromatography-mass spectrometry were used to determine the following drug concentrations (mg/L) in aortic blood: 19 mg/L metaxalone; 190 mg/L acetaminophen; 0.28 mg/L hydrocodone; and < 0.1 mg/L diazepam, nordiazepam, amitriptyline, and nortriptyline...
Comparison of the dissolution of metaxalone tablets (Skelaxin) using USP Apparatus 2 and 3. [2004.02.06]
The purpose of this study was to evaluate the effect of pH on the dissolution behavior of metaxalone in the marketed product Skelaxin tablets. The dissolution was evaluated using United States Pharmacopeia (USP) dissolution Apparatus 2 and 3 at pHs ranging from 1.5 to 7.4...
Polydrug fatality involving metaxalone. [2003.03]
A 29-year old female with a history of depression was found dead in a hotel room. The death scene investigation found empty pill bottles and an empty liter bottle of wine... This represents the first reported case to our knowledge in which a metaxalone overdose significantly contributed to death.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 2 ratings/reviews, Skelaxin has an overall score of 8.50. The effectiveness score is 9 and the side effect score is 9. The scores are on ten point scale: 10 - best, 1 - worst.
| | Skelaxin review by 41 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Muscle Spasm |
| Dosage & duration: | | 250 (dosage frequency: as needed) for the period of as needed for several years |
| Other conditions: | | headaches |
| Other drugs taken: | | OTC's | | |
Reported Results |
| Benefits: | | It relaxed the spasm's in my back and neck, if not completely, at least by 50-70 percent. The best thing about this drug is that you can take it at work or during the day, and it does not make you drowsey or loopy. |
| Side effects: | | I experienced no side effects, other then the expected outcome, which was releif of the muscle spasam. |
| Comments: | | I take this drug only as needed, when my back or neck feels tight or in spasam. It is perfect for the weekend warrior, or someone who has occassional muscle soreness and tightness. |
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| | Skelaxin review by 50 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | Neck & arm muscle spasms |
| Dosage & duration: | | 800 mg taken 1 to 3 times daily (on & off) for the period of 6+ years |
| Other conditions: | | reflux |
| Other drugs taken: | | AcipHex | | |
Reported Results |
| Benefits: | | The Skelaxin aided in my recovery from cervical disc surgery. It eased muscle spasms and tightness in my neck, chest and arm. |
| Side effects: | | The Skelaxin would (at times) make me sleepy. And it would relax my stomach muscles, allowing stomach acid to creep up into my throat and cause a burning sensation. The AcipHex would keep the stomach acid under control. |
| Comments: | | As a result of my cervical disc (5-7) surgery, my neck, chest, left shoulder/arm/hand and face have a tendency to become inflamed if I lift something heavy, I am tired or I over use my arm. Therefore, I continue to take the medications to ease my pain and numbness. Additionally, I use Motrin IB, 200-800mg, as necessary. |
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Page last updated: 2009-06-17
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