SILVADENE SUMMARY
SILVADENE Cream 1% is a soft, white, water-miscible cream containing the antimicrobial agent silver sulfadiazine in micronized form.
SILVADENE Cream 1% (silver sulfadiazine) is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.
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NEWS HIGHLIGHTS
Published Studies Related to Silvadene (Silver Sulfadiazine Topical)
Silver-coated nylon dressing plus active DC microcurrent for healing of
autogenous skin donor sites. [2013]
for autogenous skin donor sites... CONCLUSIONS: In a sample size of 25 burn patients, the addition of direct
Topical silver sulfadiazine for the prevention of acute dermatitis during irradiation for breast cancer. [2011.10.19]
PURPOSE: This study aimed to evaluate the effectiveness of topical silver sulfadiazine (SSD) in preventing acute radiation dermatitis in women receiving radiotherapy for breast cancer... CONCLUSIONS: SSD cream reduced the severity of radiation-induced skin injury compared with general skin care alone. Further studies in patients with other types of cancer and also comparing SSD cream with other topical agents are warranted.
Randomized controlled single center study comparing a polyhexanide containing bio-cellulose dressing with silver sulfadiazine cream in partial-thickness dermal burns. [2011.08]
OBJECTIVE: A prospective, randomized, controlled single center study was designed to evaluate clinical efficacy of a polyhexanide containing bio-cellulose dressing (group B) compared to a silver-sulfadiazine cream (group A) in sixty partial-thickness burn patients... CONCLUSION: Group B demonstrated a better and faster pain reduction in the treated partial-thickness burns, compared to group A. The results indicate the polyhexanide containing bio-cellulose dressing to be a safe and cost effective treatment for partial-thickness burns. Copyright (c) 2011 Elsevier Ltd and ISBI. All rights reserved.
Prevalence of pin-site infection: the comparison between silver sulfadiazine and dry dressing among open tibial fracture patients. [2011.05]
CONCLUSION: There was no significant difference in prevalence of pin-site infection between both groups (p = 0.97). Therefore, either silver sulfadiazine or dry dressing could be advocated.
The efficacy of silver mesh dressing compared with silver sulfadiazine cream for the treatment of pressure ulcers. [2011.05]
CONCLUSION: Silver mesh dressings is one of the choices for pressure ulcer treatment with good healing rate, minimal care and lower overall cost.
Clinical Trials Related to Silvadene (Silver Sulfadiazine Topical)
Evaluating the Cost-effectiveness, Efficacy, Safety and Tolerance of Mepilex� Ag Versus Silvadene� [Completed]
Effect of EGF With Silver Sulfadiazine Cream Compared With Silver Zinc Sulfadiazine Cream for Treatment of Burn Wound [Completed]
Partial thickness burn wounds are most likely to heal within 2-3 weeks mainly by mechanism
of epithelialization. However, it depends on the depth of the wounds and patient condition.
Infection is one of the most common complications causing delay in wound healing which might
affect to quality of patient's life. Generally, the standard treatment of partial thickness
burn wound is topical 1% silver sulfadiazine cream. Previous studies had been reported the
broad spectrum antimicrobial activity of silver sulfadiazine cream but it did not
demonstrate the accelerating effect of wound healing. Therefore, the combination of
substance which can promote wound healing to topical silver sulfadiazine cream might benefit
for partial thickness burn wound treatment.
The objective of this study was to compare the results of partial thickness burn wound
treatment at burn unit, Siriraj hospital with topical cream containing 1% silver
sulfadiazine plus 6% epidermal growth factor (EGF) and 1% silver zinc sulfadiazine. The
demographic data (age, sex, %body surface area burn), time of wound closure, pain and
itching, dose and type of pain and itching medication, adverse effect of topical medication,
some laboratory results and cost of expenses.
This is the prospective, double blinded, randomize-controlled study. The sample sizes were
partial thickness burn wound patients who were treated at burn unit, Siriraj hospital.
Patients were allocated into 2 groups receiving treatment with either topical silver
sulfadiazine plus EGF or silver zinc sulfadiazine. All parameter data were analyzed with
repeated measure ANOVA and independent t-test.
Dose-ranging Study of Rifaximin Soluble Solid Dispersion (SSD) Tablets for the Prevention of Complications of Early Decompensated Liver Cirrhosis [Active, not recruiting]
The primary objective of this study is to assess the efficacy of rifaximin SSD versus
placebo in preventing complications of liver cirrhosis, such as all-cause mortality (death
due to all causes) or hospitalization, in subjects with early decompensated liver cirrhosis.
Rifaximin, a non-systemic antibacterial agent, is currently marketed as a 550 mg tablet for
the reduction in risk of recurrent overt hepatic encephalopathy, a complication of liver
cirrhosis. The rifaximin SSD tablet was formulated to maximize the efficacy of rifaximin.
Subjects will receive 1 of 5 doses of rifaximin SSD tablets or placebo tablets every day for
24 weeks.
An Open, Randomized, Multi-centre Investigation With Mepilex Ag Versus Silver Sulfadiazine in the Treatment of Deep Partial Thickness Burn Injuries. [Completed]
The purpose is to compare time to healing using absorbent foam silver dressing (Mepilex Ag)
compared to a silver sulfadiazine (SSD) 1% cream in the treatment of partial thickness burn
injuries. 284 in-patients in 8-12 centres in China will be evaluated. Treatment period will
be up to 4 weeks with either Mepilex Ag or SSD.
Comparison of a Water-soluble Topical Antimicrobial to Silver Sulfadiazine in Partial Thickness Burns [Completed]
Partial thickness burns are a common, painful injury requiring a great deal of resources in
their care. Silver sulfadizine is a commonly-used topical antimicrobial, but is difficult to
remove due to its lipid base. We are comparing a water-based topical antimicrobial therapy
to silver sulfadiazine and hypothesize that the water-based therapy is superior in terms of
pain control and resources required to deliver care.
Reports of Suspected Silvadene (Silver Sulfadiazine Topical) Side Effects
Skin Discolouration (8),
Drug Hypersensitivity (5),
Skin Disorder (5),
Confusional State (2),
Urticaria (2),
Anaphylactic Shock (2),
Nausea (2),
Rash (2),
Convulsion (2),
Diarrhoea (2), more >>
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Page last updated: 2014-11-30
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