NEWS HIGHLIGHTS
Published Studies Related to Silvadene (Silver Sulfadiazine Topical)
A prospective double-blinded comparative analysis of framycetin and silver sulphadiazine as topical agents for burns: a pilot study. [2009.08]
Burn wound sepsis remains the leading cause of mortality if conservative methods of wound management are employed. Topical agents are still the mainstay of such wound management in the developing world... Framycetin application is also painless and it leads to no discoloration of the wound.
Double-lumen central venous catheters impregnated with chlorhexidine and silver sulfadiazine to prevent catheter colonisation in the intensive care unit setting: a prospective randomised study. [2009.07]
Antimicrobial- and antiseptic-impregnated catheters are strategies recommended to prevent central venous catheter (CVC) colonisation. Few data regarding chlorhexidine/silver sulfadiazine-impregnated catheters in intensive care unit (ICU) patients have been reported... Double-lumen CVCs impregnated with chlorhexidine and silver sulfadiazine were not effective in reducing the incidence of catheter colonisation in ICU patients.
Randomized clinical study of SilvaSorb gel in comparison to Silvadene silver sulfadiazine cream in the management of partial-thickness burns. [2009.03]
This prospective, randomized study assessed the clinical, microbiological, and patient comfort characteristics of two silver-based topical agents in the management of partial-thickness burn wounds. Pediatric patients were randomly assigned to treatment with either SilvaSorb Gel (Medline Industries, Munedelein, IL) or Silvadene silver sulfadiazine cream (King Pharmaceuticals, Bristol, TN) for up to 21 days or to the point of full reepithelialization of the wound...
Aloe versus silver sulfadiazine creams for second-degree burns: a randomized controlled study. [2009]
PURPOSE: Burn injury is associated with a high incidence of death and disability; yet its management remains problematic and costly. We conducted this clinical study to evaluate the efficacy of aloe vera cream for partial thickness burn wounds and compare its results with those of silver sulfadiazine (SSD)... CONCLUSION: These results clearly demonstrated the greater efficacy of aloe cream over SSD cream for treating second-degree burns.
A silver-coated antimicrobial barrier dressing used postoperatively on meshed autografts: a dressing comparison study. [2007.09]
In an effort to optimize the management of freshly grafted burn wounds, a silver-coated, low-adherence dressing, Acticoat (Smith & Nephew Inc., Largo, FL), was compared with 5% sulfamylon-soaked Exu-Dry burn wound dressings. Twenty subjects admitted to the Loyola University Medical Center were randomized to either Acticoat dressings or 5% sulfamylon-soaked burn wound dressings...
Clinical Trials Related to Silvadene (Silver Sulfadiazine Topical)
Evaluating the Cost-Effectiveness, Efficacy, Safety and Tolerance of Mepilex® Ag Versus Silvadene® in the Treatment of Partial Thickness Burns. [Recruiting]
SSD vs Collagenase in Pediatric Burn Patients [Recruiting]
The objective of this study is to evaluate the outcomes of children with burn injury with
regard to the utilization of Silver sulfadiazine (SSD) cream and Collagenase ointment. The
primary outcome variable will be need for skin grafting. The specific aim of the study is
to prospectively collect data to determine if SSD is superior to Collagenase with regard to
avoiding the need for skin grafting.
Treatment of Facial Burns With Flammacerium Compared to Flammazine and the Impact of Facial Burns on Psychosocial Wellbeing [Recruiting]
The face is involved in 40-50% of patients with burns admitted to the Dutch Burn Centres.
Scarring of the face as a consequence of burns will often have a detrimental effect on
function and aesthetics, and may cause negative effects on psychosocial wellbeing. What the
best treatment is for facial burns, minimising scarring, is unclear. Besides that, there is
little empirical evidence regarding the impact of facial scarring on psychosocial wellbeing.
In clinical practice good results are felt to be achieved by treatment of facial burns with
flammacerium. To substantiate the perceived advantages of flammacerium, its efficacy is
compared to flammazine, a current alternative of care. The efficacy of treatment will be
assessed in a prospective randomised multicentre clinical trial. Efficacy will be analysed in
terms of number of patients requiring surgery and functional and aesthetic outcome.
Apart from medical outcome, this study offers the opportunity to study psychosocial problems
associated with facial defects. It is still an unresolved question whether facial scarring
causes more or different psychosocial problems. Therefore, self-esteem and quality of life
will be examined over time, in relation to depression, posttraumatic stress symptoms and
other factors, such as coping style and social support.
By evaluating the efficacy of different treatment strategies, we aim to optimise the standard
of care of facial burns. Furthermore, this study wants to shed more light on the psychosocial
impact of facial injury. With these results psychosocial professionals will be able to focus
on persons at risk and to be better able to meet a patient's personal needs.
Topical Collagen-Silver Versus Standard Care Following Removal of Ingrown Nails [Recruiting]
This study's purpose is to prospectively determine whether topical therapy with an oxidized
regenerated cellulose collagen-silver compound is more effective than the current standard
of topical antibiotic therapy for care following the removal of an ingrown toenail. Eighty
adult patients with ingrown toenails will be recruited. Each patient will randomly be
assigned to apply either topical silver sulfadiazine cream (standard antibiotic) or the
novel collagen-silver compound to their nail bed daily, following removal of the ingrown
portion of nail. Patients will return for follow up visits weekly, until healing has
occurred or twelve weeks have passed. Healing will be defined as resolution of drainage and
inflammatory changes surrounding the nail border.
The Effect of Two Versus Ten Days Application of Flammacerium in Partial Thickness Burns [Recruiting]
The objective of the proposed study is to assess whether the application of flammacerium for
2 days is as good as, or even better than, the application of flammacerium for 10 days
regarding woundhealing in partial thickness burns.
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