NEWS HIGHLIGHTS
Published Studies Related to Silvadene (Silver Sulfadiazine Topical)
Topical silver sulfadiazine for the prevention of acute dermatitis during irradiation for breast cancer. [2011.10.19]
PURPOSE: This study aimed to evaluate the effectiveness of topical silver sulfadiazine (SSD) in preventing acute radiation dermatitis in women receiving radiotherapy for breast cancer... CONCLUSIONS: SSD cream reduced the severity of radiation-induced skin injury compared with general skin care alone. Further studies in patients with other types of cancer and also comparing SSD cream with other topical agents are warranted.
Randomized controlled single center study comparing a polyhexanide containing bio-cellulose dressing with silver sulfadiazine cream in partial-thickness dermal burns. [2011.08]
OBJECTIVE: A prospective, randomized, controlled single center study was designed to evaluate clinical efficacy of a polyhexanide containing bio-cellulose dressing (group B) compared to a silver-sulfadiazine cream (group A) in sixty partial-thickness burn patients... CONCLUSION: Group B demonstrated a better and faster pain reduction in the treated partial-thickness burns, compared to group A. The results indicate the polyhexanide containing bio-cellulose dressing to be a safe and cost effective treatment for partial-thickness burns. Copyright (c) 2011 Elsevier Ltd and ISBI. All rights reserved.
Prevalence of pin-site infection: the comparison between silver sulfadiazine and dry dressing among open tibial fracture patients. [2011.05]
CONCLUSION: There was no significant difference in prevalence of pin-site infection between both groups (p = 0.97). Therefore, either silver sulfadiazine or dry dressing could be advocated.
The efficacy of silver mesh dressing compared with silver sulfadiazine cream for the treatment of pressure ulcers. [2011.05]
CONCLUSION: Silver mesh dressings is one of the choices for pressure ulcer treatment with good healing rate, minimal care and lower overall cost.
Comparisons of the effects of biological membrane (amnion) and silver sulfadiazine in the management of burn wounds in children. [2011.03]
This prospective study was conducted on 102 children with second-degree thermal burns to assess qualitative differences between topical silver sulfadiazine (SD) and oven-dried, radiation-sterilized human amnion as wound dressing. The patients were divided into silver SD and amniotic membrane (AM) group by random sampling technique...
Clinical Trials Related to Silvadene (Silver Sulfadiazine Topical)
An Open, Randomized, Multi-centre Investigation With Mepilex Ag Versus Silver Sulfadiazine in the Treatment of Deep Partial Thickness Burn Injuries. [Recruiting]
The purpose is to compare time to healing using absorbent foam silver dressing (Mepilex Ag)
compared to a silver sulfadiazine (SSD) 1% cream in the treatment of partial thickness burn
injuries. 284 in-patients in 8-12 centres in China will be evaluated. Treatment period will
be up to 4 weeks with either Mepilex Ag or SSD.
Evaluating the Cost-Effectiveness, Efficacy, Safety and Tolerance of Mepilex® Ag Versus Silvadene® in the Treatment of Partial Thickness Burns. [Recruiting]
SSD vs Collagenase in Pediatric Burn Patients [Recruiting]
The objective of this study is to evaluate the outcomes of children with burn injury with
regard to the utilization of Silver sulfadiazine (SSD) cream and Collagenase ointment. The
primary outcome variable will be need for skin grafting. The specific aim of the study is
to prospectively collect data to determine if SSD is superior to Collagenase with regard to
avoiding the need for skin grafting.
Topical Collagen-Silver Versus Standard Care Following Removal of Ingrown Nails [Recruiting]
This study's purpose is to prospectively determine whether topical therapy with an oxidized
regenerated cellulose collagen-silver compound is more effective than the current standard
of topical antibiotic therapy for care following the removal of an ingrown toenail. Eighty
adult patients with ingrown toenails will be recruited. Each patient will randomly be
assigned to apply either topical silver sulfadiazine cream (standard antibiotic) or the
novel collagen-silver compound to their nail bed daily, following removal of the ingrown
portion of nail. Patients will return for follow up visits weekly, until healing has
occurred or twelve weeks have passed. Healing will be defined as resolution of drainage and
inflammatory changes surrounding the nail border.
Treatment of Facial Burns With Flammacerium Compared to Flammazine and the Impact of Facial Burns on Psychosocial Wellbeing [Recruiting]
The face is involved in 40-50% of patients with burns admitted to the Dutch Burn Centres.
Scarring of the face as a consequence of burns will often have a detrimental effect on
function and aesthetics, and may cause negative effects on psychosocial wellbeing. What the
best treatment is for facial burns, minimising scarring, is unclear. Besides that, there is
little empirical evidence regarding the impact of facial scarring on psychosocial wellbeing.
In clinical practice good results are felt to be achieved by treatment of facial burns with
flammacerium. To substantiate the perceived advantages of flammacerium, its efficacy is
compared to flammazine, a current alternative of care. The efficacy of treatment will be
assessed in a prospective randomised multicentre clinical trial. Efficacy will be analysed in
terms of number of patients requiring surgery and functional and aesthetic outcome.
Apart from medical outcome, this study offers the opportunity to study psychosocial problems
associated with facial defects. It is still an unresolved question whether facial scarring
causes more or different psychosocial problems. Therefore, self-esteem and quality of life
will be examined over time, in relation to depression, posttraumatic stress symptoms and
other factors, such as coping style and social support.
By evaluating the efficacy of different treatment strategies, we aim to optimise the standard
of care of facial burns. Furthermore, this study wants to shed more light on the psychosocial
impact of facial injury. With these results psychosocial professionals will be able to focus
on persons at risk and to be better able to meet a patient's personal needs.
Reports of Suspected Silvadene (Silver Sulfadiazine Topical) Side Effects
Skin Discolouration (8),
Drug Hypersensitivity (5),
Skin Disorder (5),
Confusional State (2),
Urticaria (2),
Anaphylactic Shock (2),
Nausea (2),
Rash (2),
Convulsion (2),
Diarrhoea (2), more >>
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