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Sevoflurane (Sevoflurane Liquid for Inhalation) - Summary



Sevoflurane, USP, a volatile liquid for inhalation, a nonflammable and nonexplosive liquid administered by vaporization, is a halogenated general inhalation anesthetic drug.

Sevoflurane, USP is indicated for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Sevoflurane, USP should be administered only by persons trained in the administration of general anesthesia. Facilities for maintenance of a patent airway, artificial ventilation, oxygen enrichment, and circulatory resuscitation must be immediately available. Since level of anesthesia may be altered rapidly, only vaporizers producing predictable concentrations of sevoflurane, USP should be used.

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Published Studies Related to Sevoflurane

Comparison of the effects of xenon and sevoflurane anaesthesia on leucocyte function in surgical patients: a randomized trial. [2014]
anaesthesia on leucocyte function in surgical patients... CONCLUSIONS: In vivo, xenon and sevoflurane anaesthesia did not have a

Effect of palonosetron on the QTc interval in patients undergoing sevoflurane anaesthesia. [2014]
sevoflurane anaesthesia and receive palonosetron... CONCLUSIONS: There was no significant difference in the QTc intervals during the

Desflurane/fentanyl compared with sevoflurane/fentanyl on awakening and quality of recovery in outpatient surgery using a laryngeal mask airway: a randomized, double-blinded controlled trial. [2013]
anesthetic regimen inclusive of opioids... CONCLUSIONS: Desflurane retains faster awakening properties than does sevoflurane

Prophylactic midazolam and clonidine for emergence from agitation in children after emergence from sevoflurane anesthesia: a meta-analysis. [2013]
sevoflurane anesthesia... CONCLUSIONS: This meta-analysis suggests that prophylactic administration of

Effect of one minimum alveolar concentration sevoflurane with and without fentanyl on hemodynamic response to laryngoscopy and tracheal intubation. [2011.10]
BACKGROUND: Drug combinations can be used for optimum obtundation of the hemodynamic response to tracheal intubation. The objective of this trial was to compare the hemodynamic response to laryngoscopy and tracheal intubation after administration of 2 mug/kg fentanyl bolus or a placebo with 2% end tidal sevoflurane at induction of anesthesia... CONCLUSION: Addition of 2 mug fentanyl bolus to 1 MAC sevoflurane anesthesia at induction attenuated the hemodynamic response to a maximum of 15% above baseline values.

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Clinical Trials Related to Sevoflurane

Compare Pharmaceutical Economics and Efficacy of Sevoflurane With Low Fresh Gas Flow Balanced Anesthesia, Propofol Target Controlled Infusion Anesthesia and Propofol Induction Sevoflurane Maintenance Anesthesia [Completed]
This study is being performed to compare the cost of anesthetic techniques with sevoflurane (low fresh gas flow balanced anesthesia) versus propofol (target controlled infusion [TCI]) versus propofol induction and sevoflurane maintenance anesthesia in subjects undergoing elective laparoscopic surgery with predicted anesthesic use between 1 and 3 hour duration.

Comparison of Sevoflurane, Propofol, and Sevoflurane Plus Propofol for Maintenance of Anaesthesia [Completed]
Postoperative pain may be affected by general anaesthetics. The effect of propofol and sevoflurane on postoperative pain in chinese female patients has not been demonstrated before. This study compared the postoperative pain score in patients under general anaesthesia maintained with propofol,sevoflurane, or sevoflurane+propofol.

The Effect of Sevoflurane on Cerebral CO2 Sensitivity and Systemic Arteries [Completed]

- The purpose of this study is to examine the effect of different carbon-dioxide

concentrations on cerebral CO2 sensitivity and the resistance and stiffness of systemic arteries during anesthesia with sevoflurane. Sevoflurane is a widely and commonly used inhalational anaesthetic, that is mainly used for the maintenance of general anesthesia.

- Changes in the velocity of cerebral blood flow and arterial stiffness due to the

different exhaled carbon-dioxide concentrations will allow us to conclude how sevoflurane affects these parameters during the course of the narcosis. Instruments:

- An ultrasound device called transcranial doppler (TCD) is used to measure the velocity

of blood flow within a main artery located inside the skull.

- A tonometry device named SphygmoCor is used to assess the pressure wave proceeding in

the radial artery, from which the stiffness of the systemic vessels can be concluded. Measurements:

- Examinations with the ultrasound and tonometry devices are carried out once before the

operation, three times during the intervention, with different exhaled CO2 values and once after the operation is completed. Hypothesis:

- Sevoflurane alters cerebral carbon-dioxide sensitivity and the stiffness of systemic


Sevoflurane in Electroconvulsive Therapy [Completed]
The purpose of the study was to investigate the effects of different doses of sevoflurane used in electroconvulsive therapy (ECT) on duration of seizure, hemodynamic response and recovery profiles

Sevoflurane Versus Intravenous Anaesthetic Agents in Morbid Obese Patients [Recruiting]
The objective of this prospective randomized clinical study was to compare anesthesia, in morbidly obese patents (BMI >50) who underwent BPD-RYGBP with either sevoflurane or propofol with remifentanyl.

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Reports of Suspected Sevoflurane Side Effects

Hyperthermia (135)Vomiting (73)Nausea (73)Electrocardiogram QT Prolonged (40)Foetal Exposure During Pregnancy (22)Hyperthermia Malignant (22)Stress Cardiomyopathy (20)Cardiac Arrest (20)Congenital Anomaly (18)Ventricular Fibrillation (18)more >>

Page last updated: 2014-12-01

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