SEVOFLURANE SUMMARY
Sevoflurane, volatile liquid for inhalation, a nonflammable and nonexplosive liquid administered by vaporization, is a halogenated general inhalation anesthetic drug.
Sevoflurane is indicated for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.
Sevoflurane should be administered only by persons trained in the administration of general anesthesia. Facilities for maintenance of a patent airway, artificial ventilation, oxygen enrichment, and circulatory resuscitation must be immediately available. Since level of anesthesia may be altered rapidly, only vaporizers producing predictable concentrations of sevoflurane should be used.
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NEWS HIGHLIGHTSMedia Articles Related to Sevoflurane
Patients With Sleep Apnea Undergoing Joint Replacement Have Improved Outcomes With Regional Anesthesia
Source: Arthritis / Rheumatology News From Medical News Today [2013.05.07]
Using regional anesthesia instead of general anesthesia in patients with sleep apnea undergoing total joint replacement decreases major complications by 17%, according to a study published online, ahead of print, in the journal Regional Anesthesia and Pain Medicine...
Lower Rates Of Complications In Hip And Knee Replacement Using Regional Anesthesia Technique
Source: Arthritis / Rheumatology News From Medical News Today [2013.05.03]
A highly underutilized anesthesia technique called neuraxial anesthesia, also known as spinal or epidural anesthesia, improves outcomes in patients undergoing hip or knee replacement, according to a new study by researchers at Hospital for Special Surgery...
General Anesthesia Not Linked to Raised Risk for Dementia
Source: MedicineNet Dementia Specialty [2013.05.02]
Title: General Anesthesia Not Linked to Raised Risk for Dementia
Category: Health News
Created: 5/1/2013 12:35:00 PM
Last Editorial Review: 5/2/2013 12:00:00 AM
Success Rates Of Turning Breech Babies Increased By Anesthesia, Delivery Costs Reduced
Source: Pain / Anesthetics News From Medical News Today [2013.04.22]
When a baby is in the breech position at the end of pregnancy, obstetricians can sometimes turn the baby head-down to enable a safer vaginal birth. In the past, women were not given anesthesia during the turning procedure, which requires the physician to push on the woman's abdomen while monitoring the baby with ultrasound...
Development Of Wisdom Teeth In Children May Be Affected By Dental Anesthesia
Source: Dentistry News From Medical News Today [2013.04.05]
Researchers from Tufts University School of Dental Medicine have discovered a statistical association between the injection of local dental anesthesia given to children ages two to six and evidence of missing lower wisdom teeth...
Published Studies Related to Sevoflurane
Effect of one minimum alveolar concentration sevoflurane with and without fentanyl on hemodynamic response to laryngoscopy and tracheal intubation. [2011.10]
BACKGROUND: Drug combinations can be used for optimum obtundation of the hemodynamic response to tracheal intubation. The objective of this trial was to compare the hemodynamic response to laryngoscopy and tracheal intubation after administration of 2 mug/kg fentanyl bolus or a placebo with 2% end tidal sevoflurane at induction of anesthesia... CONCLUSION: Addition of 2 mug fentanyl bolus to 1 MAC sevoflurane anesthesia at induction attenuated the hemodynamic response to a maximum of 15% above baseline values.
Prophylactic use of midazolam or propofol at the end of surgery may reduce the incidence of emergence agitation after sevoflurane anaesthesia. [2011.09]
Sevoflurane is associated with a high incidence of emergence agitation in children. Midazolam and propofol have been examined with the aim of reducing emergence agitation after sevoflurane anaesthesia...
Respiratory resistance during anaesthesia with isoflurane, sevoflurane, and desflurane: a randomized clinical trial. [2011.09]
BACKGROUND: To investigate whether the effects of desflurane on inspiratory resistance are similar to those of isoflurane and sevoflurane during 30 min administration at 1 and 1.5 MAC in patients with healthy lungs... CONCLUSIONS: In healthy adults, neither sevoflurane nor isoflurane produced bronchodilation at 1 and 1.5 MAC. Desflurane did not affect respiratory resistance at 1 MAC, but at 1.5 MAC caused significant increase in both total and airway resistance with return to near baseline values after discontinuation of the agent.
Effect of charcoal filter on the emergence from sevoflurane anesthesia in a semi-closed rebreathing circuit. [2011.07]
PURPOSE: A charcoal filter attached within the anesthetic circuit has been shown to efficiently adsorb halothane or isoflurane, thus hastening anesthetic recovery in low or minimal flow system. This study was intended to demonstrate whether the charcoal filter enhances the recovery time from sevoflurane anesthesia using a semi-closed circuit system... CONCLUSION: A charcoal filter enhances the recovery from sevoflurane anesthesia with a semi-closed rebreathing circuit.
Intravenous landiolol, a novel beta(1)-adrenergic blocker, reduces the minimum alveolar concentration of sevoflurane in women. [2011.06]
STUDY OBJECTIVE: To investigate the effect of intravenous (IV) landiolol, a novel beta(1)-adrenergic blocker, on the minimum alveolar concentration (MAC) of sevoflurane in adult women... CONCLUSIONS: IV landiolol reduces the MAC of sevoflurane in women by approximately 20%. Copyright (c) 2011 Elsevier Inc. All rights reserved.
Clinical Trials Related to Sevoflurane
Sevoflurane vs. Isoflurane for Low-Flow General Anaesthesia for Abdominal Surgery [Completed]
Two groups of patients are going to have abdominal surgery with low-flow general anaesthesia.
Group A (sevoflurane group, experimental group) will use volatile anaesthetic sevoflurane.
Group B (isoflurane group, control group) will use volatile anaesthetic isoflurane. It will
be observed differences between volatile anaesthetic sevoflurane and volatile anaesthetic
isoflurane for providing low-flow general anaesthesia for abdominal surgery. Duration of this
randomised controled trial will be approximately 2 months. Estimated sample size will be 82
persons (41 in sevoflurane group and 41 in isoflurane group).
COGNITIVE - Cognitive Function After Sevoflurane or Propofol Anesthesia for Open-Heart Operations [Suspended]
The aim of the study is to prove if general anesthesia with inhaled sevoflurane reduces the
frequency of neurological and cognitive impairment after open-heart operations with use of
cardiopulmonary by-pass (CPB) in comparison with intravenous anesthesia with propofol.
Comparison of Sevoflurane and Isoflurane Anesthesia for Benign Breast Tumor Excision [Completed]
Generally, benign breast tumors are excised under the local anesthesia. But such action was
so invasive that every patient would experience the physiological and psychological stimuli
unavoidably. Sevoflurane was advised as a better inhalational anesthesic for its "easy
come,easy go" property during short-lasting operations than isoflurane. We purposed that
sevoflurane would be a superior anesthesic for benign breast tumor excision than isoflurane
with relative less alteration in hemodynamics, less postoperative side effects and
easily-control the depth of anesthesia.
Compare Pharmaco-economics and Efficacy of Sevoflurane With Low Fresh Gas Flow Balanced Anesthesia, Propofol Target Controlled Infusion Anesthesia and Propofol Induction Sevoflurane Maintenance Anesthesia [Not yet recruiting]
This study is performed to demonstrate that the direct anesthetic costs of a low fresh gas
flow balanced sevoflurane anesthesia for elective laparoscopy are less compared to the
direct anesthetic costs of a target-controlled infusion anesthesia based on propofol.
Sevoflurane as an Anesthetic During Dilation and Evacuation Procedures [Recruiting]
Sevoflurane is an FDA-approved anesthetic drug commonly used for anesthesia during second
trimester abortion procedures. It has a few advantages, including ease of use by the
anesthesia provider. However, the literature suggests that when used in doses higher than
those used at OHSU and Lovejoy, it is associated with an increase in the risk of bleeding.
The investigators study aims to test whether the lower dose used at OHSU and Lovejoy during
second trimester abortion procedures causes any difference in blood loss, when compared to
similar abortion procedures for which this drug is not used.
Reports of Suspected Sevoflurane Side Effects
Hyperthermia (135),
Vomiting (73),
Nausea (73),
Electrocardiogram QT Prolonged (40),
Foetal Exposure During Pregnancy (22),
Hyperthermia Malignant (22),
Stress Cardiomyopathy (20),
Cardiac Arrest (20),
Congenital Anomaly (18),
Ventricular Fibrillation (18), more >>
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