SEVOFLURANE SUMMARY
Sevoflurane, volatile liquid for inhalation, a nonflammable and nonexplosive liquid administered by vaporization, is a halogenated general inhalation anesthetic drug.
Sevoflurane is indicated for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.
Sevoflurane should be administered only by persons trained in the administration of general anesthesia. Facilities for maintenance of a patent airway, artificial ventilation, oxygen enrichment, and circulatory resuscitation must be immediately available. Since level of anesthesia may be altered rapidly, only vaporizers producing predictable concentrations of sevoflurane should be used.
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NEWS HIGHLIGHTSMedia Articles Related to Sevoflurane
Abdominal Surgery Without General Anesthesia
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2009.11.04]
A recent review in Faculty of 1000 Medicine Reports, a publication in which clinicians highlight advances in medical practice, suggests regional pain relief could be used during abdominal surgery. In this review, Michael Schaefer recommends a new approach that can be performed without the need for general anaesthetics.
Anesthesia, Exertional Heat Deaths May Be Linked
Source: MedicineNet Hyperthermia Specialty [2009.10.26]
Title: Anesthesia, Exertional Heat Deaths May Be Linked
Category: Health News
Created: 10/23/2009 4:10:00 PM
Last Editorial Review: 10/26/2009
Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Source: MedicineNet Hernia Specialty [2009.03.25]
Title: Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Category: Health News
Created: 3/25/2009 2:00:00 AM
Last Editorial Review: 3/25/2009
Need For Emergency Airway Surgery For Hard-to-Intubate Patients Reduced
Source: Respiratory / Asthma News From Medical News Today [2009.11.18]
Be prepared, that old Boy Scout motto, is being applied with great success to operating room patients whose anatomy may make it difficult for physicians to help them breathe during surgery, Johns Hopkins researchers report in a new study. When patients undergo general anesthesia, they stop breathing on their own and anesthesiologists must quickly insert a tube into the airway as a first step in machine-assisted breathing.
New Technique For Injectable Facial Fillers Improves Comfort, Recovery
Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today [2009.10.29]
Less pain during injections for wrinkle-fighting facial fillers. Less swelling afterward. Less time in the office waiting for anesthesia to take effect. These and other benefits of a new injection technique that UT Southwestern Medical Center plastic surgeons are helping pioneer are outlined in the October issue of Plastic and Reconstructive Surgery.
Published Studies Related to Sevoflurane
Stem cell-like human endothelial progenitors show enhanced colony-forming capacity after brief sevoflurane exposure: preconditioning of angiogenic cells by volatile anesthetics. [2009.10]
BACKGROUND: Endothelial progenitor cells play a pivotal role in tissue repair, and thus are used for cell replacement therapies in "regenerative medicine." We tested whether the anesthetic sevoflurane would modulate growth or mobilization of these angiogenic cells... CONCLUSIONS: Sevoflurane preconditioning promotes growth and proliferation of stem cell-like human endothelial progenitors. Hence, it may be used to promote perioperative vascular healing and to support cell replacement therapies.
Preserved memory function during bispectral index-guided anesthesia with sevoflurane for major orthopedic surgery. [2009.09]
BACKGROUND: Memory function under anesthesia is undesired but may arise from light hypnosis as well as stress-enhanced learning during surgery. The bispectral index (BIS, Aspect Medical Systems, Norwood, MA) is a monitor of hypnotic state that can help to avoid light hypnosis (i.e., BIS above 60). This study tested the hypothesis that BIS-guided anesthesia maintaining BIS 50-60 reduces the likelihood of memory function under anesthesia... CONCLUSIONS: BIS titration to BIS 50-60 does not necessarily curb memory function under anesthesia when BIS values higher than 60 occur. Preoperative analgesia attenuated the likelihood of memory function under anesthesia.
A comparison between sevoflurane and desflurane anesthesia in patients undergoing craniotomy for supratentorial intracranial surgery. [2009.08]
BACKGROUND: Desflurane in neurosurgery may be beneficial because it facilitates postoperative early neurologic evaluation. However, its use has been debated because of its capacity to promote cerebral vasodilatation. Sevoflurane has been extensively used in neurosurgical patients. In this prospective clinical trial, we compared early postoperative recovery and cognitive function in patients undergoing craniotomy for supratentorial expanding lesions and receiving sevoflurane or desflurane anesthesia... CONCLUSION: Patients who received desflurane had a shorter extubation and recovery time but similar intraoperative and postoperative incidence of complications compared with those who received sevoflurane.
Desflurane versus sevoflurane for maintenance of outpatient anesthesia: the effect on early versus late recovery and perioperative coughing. [2009.08]
BACKGROUND: There is controversy regarding the relative perioperative benefits of desflurane versus sevoflurane when used for maintenance of anesthesia in the ambulatory setting. Although studies have consistently demonstrated a faster emergence with desflurane (versus sevoflurane), the impact of this difference on the later recovery end points has not been definitively established. Furthermore, the effect of desflurane (versus sevoflurane) on the incidence of coughing is also controversial... CONCLUSIONS: Use of desflurane for maintenance of anesthesia was associated with a faster emergence and a higher incidence of coughing. Despite the faster initial recovery with desflurane, no significant differences were found between the two volatile anesthetics in the later recovery period. Both volatile anesthetics should be available for ambulatory anesthesia.
Effects of different doses of remifentanil on the end-tidal concentration of sevoflurane required for tracheal intubation in children. [2009.08]
We investigated the effects of different doses of remifentanil on the end-tidal concentration of sevoflurane required for tracheal intubation in children without the use of neuromuscular blocking drugs. One hundred and thirty paediatric patients, aged 3-8 years, were randomly allocated to receive no remifentanil (group control) or remifentanil 0.1 microg kg(-1) min(-1) (group remi(0.1)), 0.2 microg kg(-1) min(-1) (group remi(0.2)), 0.3 microg kg(-1) min(-1) (group remi(0.3))...
Clinical Trials Related to Sevoflurane
Sevoflurane vs. Isoflurane for Low-Flow General Anaesthesia for Abdominal Surgery [Completed]
Two groups of patients are going to have abdominal surgery with low-flow general anaesthesia.
Group A (sevoflurane group, experimental group) will use volatile anaesthetic sevoflurane.
Group B (isoflurane group, control group) will use volatile anaesthetic isoflurane. It will
be observed differences between volatile anaesthetic sevoflurane and volatile anaesthetic
isoflurane for providing low-flow general anaesthesia for abdominal surgery. Duration of this
randomised controled trial will be approximately 2 months. Estimated sample size will be 82
persons (41 in sevoflurane group and 41 in isoflurane group).
COGNITIVE - Cognitive Function After Sevoflurane or Propofol Anesthesia for Open-Heart Operations [Suspended]
The aim of the study is to prove if general anesthesia with inhaled sevoflurane reduces the
frequency of neurological and cognitive impairment after open-heart operations with use of
cardiopulmonary by-pass (CPB) in comparison with intravenous anesthesia with propofol.
Comparison of Sevoflurane and Isoflurane Anesthesia for Benign Breast Tumor Excision [Completed]
Generally, benign breast tumors are excised under the local anesthesia. But such action was
so invasive that every patient would experience the physiological and psychological stimuli
unavoidably. Sevoflurane was advised as a better inhalational anesthesic for its "easy
come,easy go" property during short-lasting operations than isoflurane. We purposed that
sevoflurane would be a superior anesthesic for benign breast tumor excision than isoflurane
with relative less alteration in hemodynamics, less postoperative side effects and
easily-control the depth of anesthesia.
Early Cardioprotective Effect of Sevoflurane [Completed]
In vitro studies and in vivo animal experiments have shown that halogenated volatile
anesthetics have a protective effect on the ischemic myocardium. In clinical settings
however, anesthetic preconditioning may be of more interest. The aim of our study was to
evaluate the cardioprotective effect of sevoflurane in patients undergoing off-pump coronary
artery bypass surgery. We proposed that a cardioprotective effect of sevoflurane would save
myocardial function, which we measured acceleration by esophageal Doppler and cardiac index
with bolus thermodilution methods, both during brief ischemia and reperfusion.
Inhalative Sedation in ICU With Sevoflurane Via Anaesthetic Conserving Device Compared to Propofol [Completed]
The evaluation of the presented study will work on the practicability of inhalative sedation
on the ICU, potential benefits and limitations of the ACD system in a postoperative sedated
patient population in comparison to a standard intravenous sedation regimen with propofol,
and focus on renal and hepatic function, cardioprotection and pharmacoeconomics
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