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Seromycin (Cycloserine) - Indications and Dosage

 
 



INDICATIONS & USAGE

Seromycin is indicated in the treatment of active pulmonary and extrapulmonary tuberculosis (including renal disease) when the causative organisms are susceptible to this drug and when treatment with the primary medications (streptomycin, isoniazid, rifampin, and ethambutol) has proved inadequate. Like all antituberculosis drugs, Seromycin should be administered in conjunction with other effective chemotherapy and not as the sole therapeutic agent.
Seromycin may be effective in the treatment of acute urinary tract infections caused by susceptible strains of grampositive and gramnegative bacteria, especially Enterobacter spp. and Escherichia coli. It is generally no more and is usually less effective than other antimicrobial agents in the treatment of urinary tract infections caused by bacteria other than mycobacteria. Use of Seromycin in these infections should be considered only when more conventional therapy has failed and when the organism has been demonstrated to be susceptible to the drug.

DOSAGE & ADMINISTRATION

Seromycin is effective orally and is currently administered only by this route. The usual dosage is 500 mg to 1 g daily in divided doses monitored by blood levels.2 The initial adult dosage most frequently given is 250 mg twice daily at 12hour intervals for the first 2 weeks. A daily dosage of 1 g should not be exceeded.

HOW SUPPLIED

Seromycinis available as a 250 mg capsule with an opaque red cap and opaque gray body imprinted withLillyandF04in edible black ink on both the cap and the body.
Bottles of 40 (No.12) NDC 0002-0604-40

Store at controlled room temperature, 20to 25(68to 77[see USP].

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