ADVERSE REACTIONS
The most common adverse effects are gastrointestinal disturbances (nausea, vomiting, anorexia) and allergic skin reactions (such as rash and urticaria). FATALITIES ASSOCIATED WITH THE ADMINISTRATION OF SULFONAMIDES, ALTHOUGH RARE, HAVE OCCURRED DUE TO SEVERE REACTIONS, INCLUDING STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, FULMINANT HEPATIC NECROSIS, AGRANULOCYTOSIS, APLASTIC ANEMIA, OTHER BLOOD DYSCRASIAS, AND HYPERSENSITIVITY OF THE RESPIRATORY TRACT (SEE WARNINGS).
Hematologic:
Agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, neutropenia, hemolytic anemia, megaloblastic anemia, hypoprothrombinemia, methemoglobinemia, eosinophilia.
Allergic:
Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylaxis, allergic myocarditis, erythema multiforme, exfoliative dermatitis, angioedema, drug fever, chills, Henoch- Schönlein purpura, serum sickness-like syndrome, generalized allergic reactions, generalized skin eruptions, photosensitivity, conjunctival and scleral injection, pruritus, urticaria, and rash. In addition, periarteritis nodosa and systemic lupus erythematosus have been reported.
Gastrointestinal:
Hepatitis, including cholestatic jaundice and hepatic necrosis, elevation of serum transaminase and bilirubin, pseudo-membranous enterocolitis, pancreatitis, stomatitis, glossitis, nausea, emesis, abdominal pain, diarrhea, anorexia.
Genitourinary:
Renal failure, interstitial nephritis, BUN and serum creatinine elevation, toxic nephrosis with oliguria and anuria, and crystalluria.
Metabolic:
Hyperkalemia, hyponatremia.
Neurologic:
Aseptic meningitis, convulsions, peripheral neuritis, ataxia, vertigo, tinnitus, headache.
Psychiatric:
Hallucinations, depression, apathy, nervousness.
Endocrine:
The sulfonamides bear certain chemical similarities to some goitrogens, diuretics (acetazolamide and the thiazides), and oral hypoglycemic agents. Cross-sensitivity may exist with these agents. Diuresis and hypoglycemia have occurred rarely in patients receiving sulfonamides.
Musculoskeletal:
Arthralgia and myalgia.
Respiratory System:
Cough, shortness of breath, and pulmonary infiltrates (see WARNINGS).
Miscellaneous:
Weakness, fatigue, insomnia.
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REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO SEPTRA
Below is a sample of reports where side effects / adverse reactions may be related to Septra. The information is not vetted and should not be cosidered as verified clinical evidence.
Possible Septra side effects / adverse reactions in 34 year old female
Reported by a pharmacist from United States on 2007-01-25
Patient: 34 year old female weighing 54.0 kg (118.8 pounds)
Reactions: Pharyngeal Oedema, Dyspnoea, Hypersensitivity, Pruritus, Rash
Adverse event resulted in: hospitalization
Suspect drug(s):
Septra
Possible Septra side effects / adverse reactions in 23 year old male
Reported by a individual with unspecified qualification from United States on 2007-01-30
Patient: 23 year old male
Reactions: Drug Toxicity, Hepatitis, Rash Pruritic
Adverse event resulted in: hospitalization
Suspect drug(s):
Septra
Possible Septra side effects / adverse reactions in 70 year old male
Reported by a individual with unspecified qualification from United States on 2007-01-31
Patient: 70 year old male weighing 53.8 kg (118.4 pounds)
Reactions: Hypoglycaemia
Suspect drug(s):
Septra
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