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Septra (Trimethoprim / Sulfamethoxazole) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

The most common adverse effects are gastrointestinal disturbances (nausea, vomiting, anorexia) and allergic skin reactions (such as rash and urticaria). FATALITIES ASSOCIATED WITH THE ADMINISTRATION OF SULFONAMIDES, ALTHOUGH RARE, HAVE OCCURRED DUE TO SEVERE REACTIONS, INCLUDING STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, FULMINANT HEPATIC NECROSIS, AGRANULOCYTOSIS, APLASTIC ANEMIA, OTHER BLOOD DYSCRASIAS, AND HYPERSENSITIVITY OF THE RESPIRATORY TRACT (SEE WARNINGS).

Hematologic:

Agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, neutropenia, hemolytic anemia, megaloblastic anemia, hypoprothrombinemia, methemoglobinemia, eosinophilia.

Allergic:

Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylaxis, allergic myocarditis, erythema multiforme, exfoliative dermatitis, angioedema, drug fever, chills, Henoch- Schönlein purpura, serum sickness-like syndrome, generalized allergic reactions, generalized skin eruptions, photosensitivity, conjunctival and scleral injection, pruritus, urticaria, and rash. In addition, periarteritis nodosa and systemic lupus erythematosus have been reported.

Gastrointestinal:

Hepatitis, including cholestatic jaundice and hepatic necrosis, elevation of serum transaminase and bilirubin, pseudo-membranous enterocolitis, pancreatitis, stomatitis, glossitis, nausea, emesis, abdominal pain, diarrhea, anorexia.

Genitourinary:

Renal failure, interstitial nephritis, BUN and serum creatinine elevation, toxic nephrosis with oliguria and anuria, and crystalluria.

Metabolic:

Hyperkalemia, hyponatremia.

Neurologic:

Aseptic meningitis, convulsions, peripheral neuritis, ataxia, vertigo, tinnitus, headache.

Psychiatric:

Hallucinations, depression, apathy, nervousness.

Endocrine:

The sulfonamides bear certain chemical similarities to some goitrogens, diuretics (acetazolamide and the thiazides), and oral hypoglycemic agents. Cross-sensitivity may exist with these agents. Diuresis and hypoglycemia have occurred rarely in patients receiving sulfonamides.

Musculoskeletal:

Arthralgia and myalgia.

Respiratory System:

Cough, shortness of breath, and pulmonary infiltrates (see WARNINGS).

Miscellaneous:

Weakness, fatigue, insomnia.



REPORTS OF SUSPECTED SEPTRA SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Septra. The information is not vetted and should not be considered as verified clinical evidence.

Possible Septra side effects / adverse reactions in 20 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2011-12-05

Patient: 20 year old male

Reactions: Drug Eruption, Lymphadenopathy, Skin Exfoliation, Disseminated Intravascular Coagulation, Lichenoid Keratosis, Pyrexia, Transaminases Increased, Generalised Oedema, Splenic Infarction, Myalgia, Lymphocytosis, Malaise, Upper Respiratory Tract Irritation, Rash, Drug Rash With Eosinophilia and Systemic Symptoms, Eosinophilia, Renal Failure, Respiratory Failure, Septic Shock, Leukocytosis, Dermatitis Exfoliative, Human Herpesvirus 6 Infection

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Vancomycin HCL
    Dosage: 1 df, single
    Indication: Tenosynovitis

Doxycycline Hyclate
    Dosage: unk
    Indication: Tenosynovitis

Septra
    Dosage: 1 df, unk
    Administration route: Oral
    Indication: Tenosynovitis

Ceftriaxone Sodium
    Dosage: 1 df, single
    Indication: Tenosynovitis



Possible Septra side effects / adverse reactions in 20 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2011-12-06

Patient: 20 year old male

Reactions: Disseminated Intravascular Coagulation, Drug Rash With Eosinophilia and Systemic Symptoms, Splenic Infarction, Myalgia, Renal Failure, Respiratory Failure, Septic Shock, Herpes Virus Infection

Adverse event resulted in: hospitalization

Suspect drug(s):
Ceftriaxone Sodium
    Dosage: 1 df, unk
    Indication: Tenosynovitis

Vancomycin
    Dosage: 1 df, unk
    Indication: Tenosynovitis

Doxycycline Calcium
    Dosage: 1 df, unk
    Indication: Tenosynovitis

Septra
    Dosage: 1 df, unk
    Indication: Tenosynovitis



Possible Septra side effects / adverse reactions in 20 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2011-12-09

Patient: 20 year old male

Reactions: Disseminated Intravascular Coagulation, Lichenoid Keratosis, Drug Rash With Eosinophilia and Systemic Symptoms, Splenic Infarction, Myalgia, Renal Failure, Disease Recurrence, Respiratory Failure, Septic Shock, Human Herpesvirus 6 Infection

Adverse event resulted in: hospitalization

Suspect drug(s):
Septra
    Dosage: (1 dosage forms), unknown
    Indication: Tenosynovitis

Vancomycin
    Dosage: (1 dosage forms), unknown
    Indication: Tenosynovitis

Ceftriaxone
    Dosage: (1 dosage forms), unknown
    Indication: Tenosynovitis

Doxycycline
    Dosage: unknown
    Indication: Tenosynovitis



See index of all Septra side effect reports >>

Drug label data at the top of this Page last updated: 2008-08-20

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