ADVERSE REACTIONS
The most common adverse effects are gastrointestinal disturbances (nausea, vomiting, anorexia) and allergic skin reactions (such as rash and urticaria). FATALITIES ASSOCIATED WITH THE ADMINISTRATION OF SULFONAMIDES, ALTHOUGH RARE, HAVE OCCURRED DUE TO SEVERE REACTIONS, INCLUDING STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, FULMINANT HEPATIC NECROSIS, AGRANULOCYTOSIS, APLASTIC ANEMIA, OTHER BLOOD DYSCRASIAS, AND HYPERSENSITIVITY OF THE RESPIRATORY TRACT (SEE WARNINGS).
Hematologic:
Agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, neutropenia, hemolytic anemia, megaloblastic anemia, hypoprothrombinemia, methemoglobinemia, eosinophilia.
Allergic:
Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylaxis, allergic myocarditis, erythema multiforme, exfoliative dermatitis, angioedema, drug fever, chills, Henoch- Schönlein purpura, serum sickness-like syndrome, generalized allergic reactions, generalized skin eruptions, photosensitivity, conjunctival and scleral injection, pruritus, urticaria, and rash. In addition, periarteritis nodosa and systemic lupus erythematosus have been reported.
Gastrointestinal:
Hepatitis, including cholestatic jaundice and hepatic necrosis, elevation of serum transaminase and bilirubin, pseudo-membranous enterocolitis, pancreatitis, stomatitis, glossitis, nausea, emesis, abdominal pain, diarrhea, anorexia.
Genitourinary:
Renal failure, interstitial nephritis, BUN and serum creatinine elevation, toxic nephrosis with oliguria and anuria, and crystalluria.
Metabolic:
Hyperkalemia, hyponatremia.
Neurologic:
Aseptic meningitis, convulsions, peripheral neuritis, ataxia, vertigo, tinnitus, headache.
Psychiatric:
Hallucinations, depression, apathy, nervousness.
Endocrine:
The sulfonamides bear certain chemical similarities to some goitrogens, diuretics (acetazolamide and the thiazides), and oral hypoglycemic agents. Cross-sensitivity may exist with these agents. Diuresis and hypoglycemia have occurred rarely in patients receiving sulfonamides.
Musculoskeletal:
Arthralgia and myalgia.
Respiratory System:
Cough, shortness of breath, and pulmonary infiltrates (see WARNINGS).
Miscellaneous:
Weakness, fatigue, insomnia.
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REPORTS OF SUSPECTED SEPTRA SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Septra. The information is not vetted and should not be considered as verified clinical evidence.
Possible Septra side effects / adverse reactions in 20 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2011-12-05
Patient: 20 year old male
Reactions: Drug Eruption, Lymphadenopathy, Skin Exfoliation, Disseminated Intravascular Coagulation, Lichenoid Keratosis, Pyrexia, Transaminases Increased, Generalised Oedema, Splenic Infarction, Myalgia, Lymphocytosis, Malaise, Upper Respiratory Tract Irritation, Rash, Drug Rash With Eosinophilia and Systemic Symptoms, Eosinophilia, Renal Failure, Respiratory Failure, Septic Shock, Leukocytosis, Dermatitis Exfoliative, Human Herpesvirus 6 Infection
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Vancomycin HCL
Dosage: 1 df, single
Indication: Tenosynovitis
Doxycycline Hyclate
Dosage: unk
Indication: Tenosynovitis
Septra
Dosage: 1 df, unk
Administration route: Oral
Indication: Tenosynovitis
Ceftriaxone Sodium
Dosage: 1 df, single
Indication: Tenosynovitis
Possible Septra side effects / adverse reactions in 20 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2011-12-06
Patient: 20 year old male
Reactions: Disseminated Intravascular Coagulation, Drug Rash With Eosinophilia and Systemic Symptoms, Splenic Infarction, Myalgia, Renal Failure, Respiratory Failure, Septic Shock, Herpes Virus Infection
Adverse event resulted in: hospitalization
Suspect drug(s):
Ceftriaxone Sodium
Dosage: 1 df, unk
Indication: Tenosynovitis
Vancomycin
Dosage: 1 df, unk
Indication: Tenosynovitis
Doxycycline Calcium
Dosage: 1 df, unk
Indication: Tenosynovitis
Septra
Dosage: 1 df, unk
Indication: Tenosynovitis
Possible Septra side effects / adverse reactions in 20 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2011-12-09
Patient: 20 year old male
Reactions: Disseminated Intravascular Coagulation, Lichenoid Keratosis, Drug Rash With Eosinophilia and Systemic Symptoms, Splenic Infarction, Myalgia, Renal Failure, Disease Recurrence, Respiratory Failure, Septic Shock, Human Herpesvirus 6 Infection
Adverse event resulted in: hospitalization
Suspect drug(s):
Septra
Dosage: (1 dosage forms), unknown
Indication: Tenosynovitis
Vancomycin
Dosage: (1 dosage forms), unknown
Indication: Tenosynovitis
Ceftriaxone
Dosage: (1 dosage forms), unknown
Indication: Tenosynovitis
Doxycycline
Dosage: unknown
Indication: Tenosynovitis
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