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Septocaine (Articaine Hydrochloride / Epinephrine Bitartrate Subcutaneous) - Summary



(articaine hydrochloride 4% (40 mg/mL)
with epinephrine 1:100,000 injection)

Septocaine® injection is a sterile, aqueous solution that contains articaine HCl 4% (40mg/mL) with epinephrine bitartrate in a 1:100,000 strength.

Septocaine® is indicated for local, infiltrative, or conductive anesthesia in both simple and complex dental and periodontal procedures.

See all Septocaine indications & dosage >>


Media Articles Related to Septocaine (Articaine / Epinephrine Subcutaneous)

Study in mice suggests how anesthesia may fight lung infections
Source: Flu / Cold / SARS News From Medical News Today [2015.09.02]
In use for more than a century, inhaled anesthetics like nitrous oxide and halothane have made modern surgery possible.

more news >>

Published Studies Related to Septocaine (Articaine / Epinephrine Subcutaneous)

Comparison of injection pain of articaine and lidocaine in eyelid surgery. [2009.01]
PURPOSE: To compare the pain induced by tissue infiltration of lidocaine 2% with epinephrine 1:100,000 versus articaine 4% with epinephrine 1:100,000 for eyelid surgery... CONCLUSIONS: In this study, infiltration of articaine was less painful than lidocaine for eyelid surgery, making articaine an attractive alternative for local anesthesia.

The incidence of adverse reactions following 4% septocaine (articaine) in children. [2008.09]
PURPOSE: The purpose of this study was to report the incidence of adverse events following the use of 4% Septocaine in children... CONCLUSIONS: Since prolonged numbness appears to be the most frequent adverse event and occurred primarily in children younger than 7 years old, parents need to be informed and reassured accordingly.

Allergic reaction caused by articaine. [2005.03]
We report the case of a 51-year-old woman who had an immediate skin reaction after subcutaneous administration of a local anesthetic (LA) composed of articaine and epinephrine before a dental procedure. The patient subsequently underwent further dental procedures without LA... Provocations with the remaining anesthetics of the amide group were not carried out due to the patient's refusal.

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Clinical Trials Related to Septocaine (Articaine / Epinephrine Subcutaneous)

Topical Pharyngeal Anesthesia With Articaine for Gastroscopy [Completed]
Topical Pharyngeal anesthesia (TPA) is widely used during upper endoscopy. Articaine is local anaesthetic that have not been previously evaluated in pharyngeal anesthesia for upper endoscopy. The aim of this study was to compare pharyngeal anesthesia with 4% articaine to placebo (Na0,9%) during gastroscopy in terms of benefit on patients` and endoscopists` satisfaction.

Evaluation of the Success Rate of Pulpal Anesthesia in Mandibular First Molar Following Infiltration of 4% Articaine Alone and as Supplemental Injection After Inferior Alveolar Nerve Block [Completed]
The purpose of this study is to determine the success rate of pulpal anesthesia in mandibular firs molar following infiltration of 4% articaine alone and as supplemental injection after inferior alveolar nerve block(IANB).

Lower Third Molar Removal With 2% and 4% Articaine [Completed]
The present clinical trial randomized compared the clinical efficacy of the local anesthetics articaine in two concentrations, 2% and 4%, in association with 1: 200,000 adrenaline, for the removal of lower third molars. Onset, duration of postoperative analgesia, duration of anesthetic action on soft tissues, intraoperative bleeding, hemodynamic parameters, postoperative mouth opening and wound healing at the 7th postoperative day were evaluated. For this purpose, 50 healthy volunteers underwent removal of symmetrically positioned lower third molars, in two separate appointments (one to two months apart), under local anesthesia with either articaine 2% or 4% (both with 1: 200,000 adrenaline) in a double-blind, randomized and crossed manner.

Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars [Completed]
The purpose of this study is to study the ability of a frequently used dental anesthetic (articaine) to achieve complete numbness of a diseased tooth with the most commonly used injection technique in the lower jaw (inferior alveolar nerve block: IANB). If this technique fails, a commonly used supplemental technique with one of two possible dental anesthetics (lidocaine or articaine) will be given to evaluate the success/failure of complete numbness between the two anesthetics. The investigators hypothesize that supplemental infiltration anesthesia with articaine will give the same success rate as lidocaine in achieving complete pulpal anesthesia in mandibular molars with irreversible pulpitis.

Anesthetic Efficacy of 1,8mL and 3,6mL of Articaine in Inferior Alveolar Nerve Block in Irreversible Pulpitis [Not yet recruiting]
Eighty patients with irreversible pulpitis diagnostic will participate in this clinical study. The participants will be divided into 2 groups of 40 patients, who will receive the inferior alveolar nerve block injections of 1. 8 mL of 4% articaine (Articaine 100; DFL, Rio de Janeiro, RJ, Brazil) with 1: 100,000 epinephrine or 3. 6mL of the same solution. Two consecutive negative responses to the maximum pulp stimulus (80 ľA) at the electric pulp test were the criterion to determine a pulpal anesthesia as successful. Ten minutes after the IAN block, subjective lip anesthesia will be evaluated by asking the patient whether his/her lip was numb. Thereafter and immediately before the pulpectomy, the electric pulp stimulations will be repeated to determine pulpal anesthesia. During the pulpectomy procedure, the patients were instructed to report any painful discomfort. To evaluate the intensity of pain during the pulpectomy, a verbal analogue scale will be used. The anesthesia will be defined as successful when the dentist accessed the pulp chamber without pain being reported by the patient. In these cases, the pulpectomy will be continued. If report pain will classified the IAN block as unsuccessful.

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Reports of Suspected Septocaine (Articaine / Epinephrine Subcutaneous) Side Effects

Dyspnoea (15)Atelectasis (12)Dental Plaque (12)Device Related Infection (12)Multiple Myeloma (12)Pyrexia (12)Sedation (12)Tooth Discolouration (12)Hypoxia (12)Intervertebral Disc Degeneration (12)more >>

Page last updated: 2015-09-02

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