Sensorcaine® (bupivacaine HCl) injections are sterile isotonic solutions that contain a local anesthetic agent with and without epinephrine (as bitartrate) 1:200,000 and are administered parenterally by injection. See INDICATIONS AND USAGE for specific uses. Solutions of bupivacaine HCl may be autoclaved if they do not contain epinephrine.
Sensorcaine (bupivacaine HCl) is indicated for the production of local or regional anesthesia or analgesia for surgery, oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Only the 0.25% and 0.5% concentrations are indicated for obstetrical anesthesia (see WARNINGS).
Experience with non-obstetrical surgical procedures in pregnant patients is not sufficient to recommend use of the 0.75% concentration of bupivacaine HCl in these patients. Sensorcaine is not recommended for intravenous regional anesthesia (Bier Block) (see WARNINGS).
The routes of administration and indicated Sensorcaine concentrations are:
local infiltration 0.25%
peripheral nerve block 0.25%, 0.5%
retrobulbar block 0.75%
sympathetic block 0.25%
lumbar epidural 0.25%, 0.5% and 0.75% (non-obstetrical)
caudal 0.25%, 0.5%
epidural test dose (see PRECAUTIONS)
(see DOSAGE AND ADMINISTRATION for additional information).
Standard textbooks should be consulted to determine the accepted procedures and techniques for the administration of Sensorcaine. Use only the single dose ampules and single dose vials for caudal or epidural anesthesia; the multiple dose vials contain a preservative and, therefore, should not be used for these procedures.
Media Articles Related to Sensorcaine MPF (Bupivacaine)
Combining dental, medical procedures may safely limit children's anesthesia exposure
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Children who require both dental and non-dental medical procedures should have them completed under one general anesthesia session whenever possible, which is ideal for both the patient and family...
Trends in Tramadol: Pharmacology, Metabolism, and Misuse
Source: Medscape Anesthesiology Headlines [2017.02.15]
Learn about the unique characteristics of tramadol, its pharmacogenomic considerations, and its potential for abuse in this comprehensive review.
Anesthesia & Analgesia
UW study: Incidence of consciousness during surgery lower than previous estimates
Source: Pain / Anesthetics News From Medical News Today [2016.12.19]
An international study of 260 surgical patients found that, contrary to many previous studies, just more than four percent were conscious of the external world while under general anesthesia but...
Published Studies Related to Sensorcaine MPF (Bupivacaine)
Pre-emptive peritonsillar dexamethasone vs. levobupivacaine infiltration for
relief of post-adenotonsillectomy pain in children: a controlled clinical study. 
pediatric adenotonsillectomy patients... CONCLUSION: Peritonsillar dexamethasone infiltration was more effective than both
Intra-articular bupivacaine reduces postoperative pain and meperidine use after
total hip arthroplasty: a randomized, double-blind study. 
One hundred patients receiving unilateral total hip arthroplasty (THA) were
randomized to receive an intra-articular injection of 300mg bupivacaine or normal
saline after completion of surgery. Pain scores of the bupivacaine group were
significantly lower than those of the control group the first 12hours
postoperatively (all, P<0.001).
Efficiency of bupivacaine versus lidocaine and methylprednisolone versus placebo
to reduce postoperative pain and swelling after surgical removal of mandibular
third molars: a randomized, double-blinded, crossover clinical trial. 
swelling after surgical removal of mandibular third molars... CONCLUSIONS: Bupivacaine combined with methylprednisolone reduced the
A comparison of two different doses of bupivacaine in caudal anesthesia for
neonatal circumcision. A randomized clinical trial. 
anesthesia... CONCLUSIONS: Low volume high concentration caudal bupivacaine provided a similar
Spinal anaesthesia for pelvic surgery: low concentrations of lignocaine and
bupivacaine are effective with less adverse events. 
subarachnoid block for pelvic surgeries... CONCLUSION: [corrected] For subarachnoid block for pelvic surgeries longer than
Clinical Trials Related to Sensorcaine MPF (Bupivacaine)
2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula [Recruiting]
Comparison of Standard and Minidose Spinal Anesthesia for Cesarean Section Operation Using Marcaine Spinal 0.5% Heavy [Not yet recruiting]
The objectives of this study is to test a combination of low dose local anesthetic
Bupivacaine diluted in patient's CSF with lipophilic opiate Fentanyl for optimal spinal
anesthesia during Cesarean Section. The dilution of Bupivacaine with CSF in our study would
result in effective spinal anesthesia with relatively limited motor block, quick recovery of
motor function and relatively long lasting analgesia. We expect lower incidence of side
effects with this combination than with convenient dose of Bupivacaine.
ED50 and ED95 of Intrathecal Bupivacaine With or Without Epinephrine for Total Knee Replacement Arthroplasty [Completed]
This prospective randomized double-blind dose-response study is aimed to investigate the
ED50 and ED95 of intrathecal bupivacaine with or without epinephrine 100 mcg for total knee
Efficacy of Interscalene Brachial Plexus Block With Liposomal Bupivacaine for Arthroscopic Shoulder Surgery [Completed]
The purpose of this study is to compare the quality and duration of pain relief after
shoulder surgery provided by a single injection of liposomal bupivacaine versus standard
bupivacaine when administered as an interscalene brachial plexus block. It is hypothesized
that the liposomal bupivacaine formulation will provide more effective pain relief than
Efficacy of Single Injection Femoral Nerve Block With Liposomal Bupivacaine for Total Knee Arthroplasty [Not yet recruiting]
The purpose of this study is to compare the quality and duration of pain relief after a
total knee replacement provided by a single shot of standard bupivacaine versus a single
shot of liposomal bupivacaine, at the site of the femoral nerve. It is hypothesized that the
liposomal bupivacaine formulation will provide more effective pain relief than standard