NEWS HIGHLIGHTS
Published Studies Related to Selenium Sulfide (Selenium Sulfide Topical)
A double-blind comparative study of sodium sulfacetamide lotion 10% versus selenium sulfide lotion 2.5% in the treatment of pityriasis (tinea) versicolor. [2004.06]
Pityriasis (tinea) versicolor, which consists of hyperpigmented and hypopigmented scaly patches, is often difficult to treat. A double-blind comparative study between once-a-day sodium sulfacetamide lotion and selenium sulfide lotion was undertaken... Selenium sulfide was statistically more efficacious (76.2% vs 47.8%, P=.013).
Comparison of 1% and 2.5% selenium sulfide in the treatment of tinea capitis. [1995.07]
OBJECTIVE: To determine whether an over-the-counter shampoo containing 1% selenium sulfide would have sporicidal activity equal to that of a 2.5% selenium sulfide prescription lotion in the adjunctive treatment of tinea capitis infection. DESIGN: Prospective randomized nonblinded clinical trial. SETTING: Outpatient clinics and emergency department of a children's hospital. PATIENTS: Fifty-four patients between the ages of 1 and 15 years with culture-proved tinea capitis infection caused by Trichophyton tonsurans enrolled during a 14-month period... CONCLUSION: Commercially available 1% selenium sulfide shampoo is an equally effective yet less expensive alternative sporicidal therapy in the adjunctive treatment of tinea capitis infection.
A randomized, double-blind, placebo-controlled trial of ketoconazole 2% shampoo versus selenium sulfide 2.5% shampoo in the treatment of moderate to severe dandruff. [1993.12]
BACKGROUND: Ketoconazole is highly effective against the yeast Pityrosporum ovale, an organism believed to be involved in the pathogenesis of dandruff. OBJECTIVE: Our purpose was to evaluate the safety and effectiveness of ketoconazole 2% shampoo versus selenium sulfide 2.5% shampoo and placebo shampoo in patients with moderate to severe dandruff... CONCLUSION: Both ketoconazole 2% shampoo and selenium sulfide 2.5% shampoo are effective in the treatment of moderate to severe dandruff; however, ketoconazole 2% shampoo appears to be better tolerated.
Xanthotrichia (yellow hair) due to selenium sulfide and dihydroxyacetone. [2008.07]
Hair shaft discoloration has been documented to be caused by disease states, medications, and exogenous chemicals. After researching the literature, xanthotrichia or yellow hair has been determined to be caused predominately by exogenous chemicals.
Effect of dietary selenium on the promotion of hepatocarcinogenesis by 3,3', 4,4'-tetrachlorobiphenyl and 2,2', 4,4', 5,5'-hexachlorobiphenyl. [2008.03]
Polychlorinated biphenyls (PCBs) are persistent organic pollutants that have promoting activity in the liver. PCBs induce oxidative stress, which may influence carcinogenesis.The effects of Se on altered hepatic foci do not correlate with its effects on GPx and TrxR.
Clinical Trials Related to Selenium Sulfide (Selenium Sulfide Topical)
Optimization of Selenoprotein P in Chinese Subjects [Active, not recruiting]
Selenium Supplementation in Chronic Obstructive Pulmonary Disease (COPD) Patients [Completed]
Does an oral selenium supplement increase blood levels of antioxidants in patients with
established, smoking-related lung disease?
Members of our study group recently discovered that elevated levels of the anti-oxidant GPx-1
may be protective against heart disease. We are studying whether selenium supplementation
will improve GPx-1 levels.
Selenium in Treating Patients Who Are Undergoing Brachytherapy for Stage I or Stage II Prostate Cancer [Active, not recruiting]
RATIONALE: The use of nutritional supplements, such as selenium, may stop prostate cancer
from growing. Internal radiation, such as brachytherapy, uses radioactive material placed
directly into or near a tumor to kill tumor cells. Giving selenium before brachytherapy may
be an effective treatment for prostate cancer.
PURPOSE: This randomized phase II trial is studying selenium to see how well it works
compared to placebo in treating patients who are undergoing brachytherapy for stage I or
stage II prostate cancer.
Selenium, as Sodium Selenite, in the Treatment of Septic Shock [Completed]
Septic shock is a frequent syndrome with a 45% mortality rate despite intensive care unit
(ICU) care, where free radicals may play a key role, and a >40% decrease in plasma selenium
concentration is observed. Selenium is a trace element with both indirect enzymatic
anti-oxidant, and direct oxidant properties. High dose of sodium selenite administration
could increase antioxidant cells capacities, and reduce inflammation by a direct paradoxical
pro-oxidative effect. We conduct a study to evaluate the effects of selenium treatment in
comparison to placebo, in septic shock patients. Efficacy will be evaluated by the weaning
time of catecholamines.
Partnership on Nutrition and HIV/AIDS Research in Tanzania: Exploratory Research Study on Selenium and HIV Infection [Completed]
The purpose of this study is to determine whether the oral administration of daily selenium
supplements to HIV-1 positive pregnant women: enhances immune status and reduces the HIV-1
viral load at six months postpartum, reduces the risk of lower genital shedding of HIV-1
infected cells at 36 weeks of gestation, and reduces the risk of mastitis at six weeks
postpartum, compared to placebo.
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