DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Seasonique (Levonorgestrel / Ethinyl Estradiol / Ethinyl Estradiol) - Summary

 
 



BOX WARNING

Cigarette smoking increases the risk of serious cardiovascular side effects from oral contraceptive use. This risk increases with age and with heavy smoking (15 or more cigarettes per day) and is quite marked in women over 35 years of age. Women who use oral contraceptives should be strongly advised not to smoke.

 

SEASONIQUE SUMMARY

SEASONIQUETM
(levonorgestrel / ethinyl estradiol tablets) 0.15 mg / 0.03 mg and
(ethinyl estradiol tablets) 0.01 mg

SeasoniqueTM (levonorgestrel/ethinyl estradiol combination tablets and ethinyl estradiol tablets) is an extended-cycle oral contraceptive consisting of 84 light blue-green tablets each containing 0.15 mg of levonorgestrel, a synthetic progestogen and 0.03 mg of ethinyl estradiol, and 7 yellow tablets containing 0.01 mg of ethinyl estradiol.

SeasoniqueTM tablets are indicated for the prevention of pregnancy in women who elect to use oral contraceptives as a method of contraception.

Clinical Studies

PSE-301 was a randomized, multicenter, open-label study designed to evaluate the safety and efficacy of SeasoniqueTM for approximately 1 year (four 91-day SeasoniqueTM extended cycles). A total of 1,006 sexually active adult women of childbearing potential, 18 to 40 years of age, were treated and completed 2,488 SeasoniqueTM 91-day cycles. The principal cohort for efficacy included only patients 18 to 35 years of age who completed at least one 91-day cycle treatment cycle. Cycles in which another form of birth control was used (including condoms) were excluded from the efficacy analysis. The overall Pearl Index was 1.77, based on 7 pregnancies in 1,578 completed 91-day treatment cycles.

Oral contraceptives are highly effective for pregnancy prevention. Table 2 lists the typical unintended pregnancy rates for users of combination oral contraceptives and other methods of contraception. The efficacy of these contraceptive methods, except sterilization, the IUD, and Norplant® Implant System, depends upon the reliability with which they are used. Correct and consistent use of methods can result in lower failure rates.


See all Seasonique indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Seasonique (Levonorgestrel / Estradiol / Estradiol)

Research reveals more than half of young women who have abortions were using contraception when they fell pregnant
Source: Abortion News From Medical News Today [2014.04.30]
Reproductive health charity Marie Stopes UK has launched the findings of the first research in the UK into the contraceptive use of women aged 16-24 having one or more abortions.

New study finds that the probability of unprotected intercourse in hookups doubles between freshman
Source: Sexual Health / STDs News From Medical News Today [2014.10.20]
An article released by Social Forces titled, "Casual Contraception in Casual Sex: Life-Cycle Change in Undergraduates' Sexual Behavior in Hookups" by Jonathan Marc Bearak (New York University)...

Long-Acting Contraceptives Still Often Not Free for Women
Source: MedPage Today OB/Gyn [2014.10.12]
(MedPage Today) -- ACA's promise of free contraception still often unfulfilled.

Free birth control reduces teen pregnancies and abortions
Source: Abortion News From Medical News Today [2014.10.03]
Teens who received free contraception and were educated about the pros and cons of various birth control methods were dramatically less likely to get pregnant, give birth or get an abortion compared...

more news >>

Clinical Trials Related to Seasonique (Levonorgestrel / Estradiol / Estradiol)

Effects of Administration of Fostamatinib on Blood Concentrations of an Oral Contraceptive in Healthy Female Subjects [Recruiting]
A crossover study to assess the effect of repeated doses of fostamatinib on the levels of oral contraceptive (Microgynon® 30) in the blood of healthy female subjects. The study will consist of a screening period of up to 35 days, followed by 2 treatment periods (28 days each) of an oral contraceptive (Microgynon® 30) in the absence and presence of fostamatinib. The study will also evaluate the safety and tolerability of fostamatinib in combination with an oral contraceptive

AZD6140 Oral Contraceptive Interaction Study [Recruiting]

A Study to Evaluate Suppression of the Pituitary-Ovarian Axis With Three Different Oral Contraceptive Regimens [Completed]
This is a randomized, open-label study to evaluate pituitary ovarian suppression in healthy, reproductive-aged women using three different regimens of oral contraceptives (OCs). Two extended regimen OCs, Seasonale (levonorgestrel/ethinyl estradiol 0. 15/0. 03 mg for 84 days followed by 7 days of placebo), and Seasonique (levonorgestrel/ethinyl estradiol 0. 15/0. 03 mg for 84 days followed by 7 days of ethinyl estradiol 0. 01 mg), and a 28-day regimen OC, Portia (levonorgestrel/ethinyl estradiol 0. 15/0. 03 mg for 21 days followed by 7 days of placebo).

A Study to Investigate the Potential Pharmacokinetic Interaction of Perampanel With Oral Contraceptives in Healthy Female Subjects [Recruiting]

A Study of Efficacy and Safety With the Transdermal Contraceptive System Versus Triphasil. [Completed]
The purpose of the study was to compare the contraceptive efficacy and safety of the transdermal patch to Triphasil.

more trials >>

Reports of Suspected Seasonique (Levonorgestrel / Estradiol / Estradiol) Side Effects

Pain (3)Hot Flush (3)Night Sweats (2)Endometriosis (2)Pulmonary Embolism (2)Menstruation Irregular (2)Fatigue (2)Dizziness (2)Anaemia (2)Bile Duct Obstruction (1)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 28 ratings/reviews, Seasonique has an overall score of 5.07. The effectiveness score is 8.43 and the side effect score is 5.21. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Seasonique review by 18 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   unregulated periods
Dosage & duration:   1 pill per day taken 1 pill per day for the period of few weeks
Other conditions:   n/a
Other drugs taken:   n/a
  
Reported Results
Benefits:   I was on YAZ for over a year, played on three soccer teams (two were for high school) and still gained 5 lbs. After i switched to seasonique a few weeks ago, i lost my appetite and lost weight. I dont eat nearly as much now. Im 5'0'' and before i switched i used to weigh roughly around 115... now im sticking around 105. i have no experience with the bad side effects with seasonique
Side effects:   none
Comments:   one pill a day at the same time

 

Seasonique review by 25 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Preventing Pregnancy
Dosage & duration:   3 month dose (dosage frequency: since june 2009) for the period of Since June 2009
Other conditions:   No Sex Drive
Other drugs taken:   n/a
  
Reported Results
Benefits:   preventing pregnancy
Side effects:   This pill was great b/c i didn't have any periods and also prevented pregnancy, but that doesn't help you don't have ANY sex drive. I didn't have any sex drive at all... not decreased. none at all. horrible. switching back to Ortho-Tricyclene lo. I'd been on that since 2002.
Comments:   n/a

 

Seasonique review by 18 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   ovarian cysts.
Dosage & duration:   N/A (dosage frequency: everyday.) for the period of 3 months.
Other conditions:   none.
Other drugs taken:   none.
  
Reported Results
Benefits:   To reduce pain during periods.
Side effects:   High depression, anxiety attacks, heart palpitations.
Comments:   The pill was nice to keep you off your period, i took my pill everyday at different times, but the side effects were effecting the way i was living. I couldn't handle the depression, and anxiety. I felt like i was losing it. During the pill use, i was getting dizzy spells, after a while i just felt like i couldn't handle going through a day.

See all Seasonique reviews / ratings >>

Page last updated: 2014-10-20

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2014